JCI Table of Contents -- July 2, 2007
...E: Neutrophil-mediated innate immune resistance to mycobacteria AUTHOR CONTACT: Adrian R. Martineau or Robert J. Wilkinson Wellcome Trust Center for Research in Clinical Tropical Medicine, Imperial College London, United Kingdom. Phone: 44-207-594-3915; Fax: 44-207-594-3894; E-mail: a.martineau@imperial....Einstein researchers find potential new drugs for tuberculosis
...t 2-HA and 2-OA were actually being metabolized in mycobacteria into two different drugs, each of which inhibits a different biochemical pathway," says Dr. Catherine Vilchze, a study co-author in Dr. Jacobs' laboratory. "The pathways that they block - fatty acid and mycolic acid synthesis and fatty acid degradati...Experimental TB drug effective against resistant and latent mycobacterium tuberculosis
...0013 is directed specifically against slow growing mycobacteria that cause the disease rather than at a broad array of non-pathogenic organisms, which merely enhances the emergence of drug- resistant strains. No resistance has been encountered to FAS20013 in clinical isolates,. The short-term killing power of FAS...Ironing out new details of tuberculosis infection
...Instead of using siderophores that diffuse freely, mycobacteria anchor their siderophores to lipid membranes by me...y to the very compartment in macrophages where the mycobacteria are lurking. Using microarray data, the available literature, and intuition, Gokhale's group identif...Preventing bacterial biofilms could help fight TB
...leprosy--to form biofilms. Bacterial biofilms help mycobacteria resist treatment. But researchers found that when mycobacteria closely related to the TB and leprosy pathogens lack one key protein, mature biofilms fail to form. ...K-State professor developing new strategies for delivery of drugs to fight, treat tuberculosis
...lly all of its metabolics, Bossmann said. When the mycobacteria senses something dangerous like antibiotics, it simply closes the channel. Bossmann's research is targeting the channels. "It is the only way for the cells to have an exchange with the outside world as far as we know: to block them and put complexes......MUNOLOGY Acquired defects confer susceptibility to mycobacteria infection Susceptibility to mycobacterial infecti...f the mechanisms responsible for susceptibility to mycobacteria in these patients has important implications for our understanding of immunity to tuberculosis and o...