Tag: "myelin" at biology news

JCI table of contents, March 16, 2006

... white blood cells known as lymphocytes attack the myelin insulation on nerves in the spinal cord and brain....on and reversal of clinical MS severity, with less myelin loss, CNS inflammation, and MS disease incidence. The authors then treated isolated inflammatory cel...

New evidence suggests statins could prove useful in treating MS

...ization with the protein that induces EAE (MBP, or myelin basic protein). Of these, only three developed par...l nervous system, and decreased destruction of the myelin sheath, which insulates the nerves and is the target of destruction in MS. In contrast, there was no...

New 'stars' in formation of nerve cell insulation

The insulating myelin sheath enwrapping the cable-like axons of nerve ce...ducing cells, called oligodendrocytes, to form the myelin membrane surrounding the nerve cells. In their studies, the researchers cultured rat and mice neuron...

News tips from the Journal of Neuroscience

...ramers in trans that allow for the compaction of myelin layers. Although mutations in myelin protein zero [ MPZ ], P0 ) are well-known causes of neuropathy, the clinical phenotypes vary widel...

Discoveries may advance stem cell therapy for Parkinson's, cancer patients

...vous system. The products of Cgt contribute to the myelin sheath that coats and protects nerve cells, they explained. Mice with other nervous system defects also exhibited a failure to mobilize bone marrow stem cells, they found. Moreover, drugs that stimulate the sympathetic nervous system restored stem ce...

Role of the nervous system in regulating stem cells discovered

...vous system. The products of Cgt contribute to the myelin sheath that coats and protects nerve cells, they explained. Mice with other nervous system defects also exhibited a failure to mobilize bone marrow stem cells, they found. Moreover, drugs that stimulate the sympathetic nervous system restored stem ce...

JCI table of contents: January 12, 2006

... from destruction of the nerve-insulating material myelin by activated T cells. Leptin is known to play a critical role in the regulation of food intake, metabolism, and the immune response. Since it had been previously shown that leptin is expressed in active inflammatory lesions of the central nervous sys...

Imaging study links key genetic risk for Alzheimer's disease to myelin breakdown

...chiatry and add to a growing body of evidence that myelin breakdown is a key contributor to the onset of Alz...ic testing coupled with non-invasive evaluation of myelin breakdown through magnetic resonance imaging (MRI) may prove useful in assessing treatments for prev...

New UW study offers strategy for treatment of fatal nervous system disorder

...those afflicted with Krabbe's disease, the loss of myelin results in arrested motor and mental development, ...ells with the enzyme, the cells would maintain the myelin as healthy cells would," says Duncan, the senior author of the PNAS paper who planned and conducted ...

Scientists push forward understanding of multiple sclerosis

...ases like multiple sclerosis (MS) which attack the myelin sheath an insulator which protects the body's ner...ed cells called glia, which surround nerves with a myelin sheath. The nerves of babies are surrounded by these glial cells in the first few years after birth,...

Breakdown of myelin insulation in brain's wiring implicated in childhood developmental disorders

... brain tissue. The high cholesterol content allows myelin to wrap tightly around axons, speeding messages th...mortem tissue data suggests that the production of myelin is a key component of brain development through childhood and well into middle age, when development...

Multiple sclerosis progression linked to immune-cell substance

...ssues in the body. In MS, immune cells destroy the myelin sheath that surrounds nerve fibers in the brain an... develop the disease after being inoculated with a myelin protein. The researchers compared these mice to mice that were identical except that they lacked the...

Adult human neural stem cell therapy successful in treating spinal cord injury

...iated into new oligodendrocyte cells that restored myelin around damaged mouse axons. Additionally, transpla...cal conduction in the central nervous system. When myelin is stripped away through disease or injury, sensory and motor deficiencies result and, in some cases...

Scientists discover the molecular switch for nerve cells' insulating jelly rolls

...he team identified a gene called neuregulin as the myelin signal. This signal directs Schwann cells, the ner...cellular architects, to build elaborate sheaths of myelin around the axons of nerve cells. Axons are the long cable-like arms of nerve cells that send message...

$3.4 million directed to key UW-Madison MS study

...ues that may one day be used to repair the damaged myelin -- the critical sheathing of nervous system fibers...itating and unpredictable disease. "It's all about myelin repair and protecting nerve fibers," says Duncan, an international authority on myelin and myelin-re...

OHSU researchers discover potential mechanism to repair brain damage linked to MS

... that the tremors were associated with the loss of myelin sheaths on nerve cells, very similar to the myelin loss associated with MS and other neurological diseases, as well as in premature infants. In additio...

Jonathan Baell wins Biota Award for Medicinal Chemistry

...e autoimmune impact of the body's own T cells upon myelin proteins. Myelin is the substance that, in effect...ainly far too weak in its natural state to prevent myelin destruction. Dr Baell and his collaborators in Australia and overseas have determined that it is pos...

Combination therapy leads to partial recovery from spinal cord injury in rats

...that producing a nerve-insulating substance called myelin can lead to functional improvements in animals wit...ury. Previous studies have shown that the loss of myelin around nerve fibers contributes to the impaired function after a spinal cord injury. However, until...

Researchers find molecule that inhibits regrowth of spinal nerve cells

...d cells, the researchers found that a component of myelin a substance that normally insulates and stabilize... blocks the ability of nerve cells to grow through myelin that is released when the spinal cord is damaged.While other myelin components also block nerve grow...

Gene changes linked to deficient immune suppression in MS

...of autoimmune T-cells, including those that target myelin within the brain and spinal cord. But only recently have scientists begun recognizing the direct involvement of T-regs in suppressing pathogenic T-cells. "There has been no specific marker for them," Vandenbark said. For the Journal of Neuroscience ...

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(Date:7/31/2014)... A hidden hazard lurks beneath many of the ... , The hazard is corrosion in parts of ... failures, leaks and contamination of groundwater, a source ... in nine states have reported many rapidly corroding ... These incidents are generally associated with use of ...
(Date:7/31/2014)... German . , ... a sponge that soaks up liquids. Hence, these highly ... gases. However, loading of many MOFs is inhibited by ... report in Nature Communications that the barriers ... can be prevented by water-free synthesis and storing strategies. ...
(Date:7/31/2014)... Prolonged exposure to loud noise alters how the ... distinguishing speech sounds, according to neuroscientists at The ... paper published this week in Ear and ... how noise-induced hearing loss affects the brain,s recognition ... reaches all corners of the population, affecting an ...
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