Cardiac patches stimulate regeneration, improve function after heart attack
...heorized that placing periostin near the site of a myocardial infarction could help restore this growth-friendly environment and get heart tissue to regenerate. Kuhn and colleagues at Massachusetts General Hospital and the Mount Sinai School of Medicine first stimulated mature, rod-shaped heart muscle cells (...Prenatal nicotine exposure can lead to cardiac function reprogramming in adult offspring
...n of blood flow ischemia followed by 60-minutes of myocardial impairment caused by opening of the blockage. Pulmonary artery discharge was collected as an index of coronary flow (ml/min/g heart wet weight). Summary of Results The researchers found: that nicotine significantly decreased coronary flow i...Biotechnology Study Center honors Joan V. Ruderman, Salvador Moncada and Charles N. Serhan
...impact on cardiovascular mortality from stroke and myocardial infarction worldwide. He next elucidated the structure of prostacyclin, a compound formed by endothelial cells that relaxes blood vessels and prevents platelets from clumping; its derivatives ameliorate vasospasm and pulmonary hypertension. But perha...Adult stem cells to repair hearts damaged by severe coronary artery disease investigated
...oms and clinical outcomes in subjects with chronic myocardial ischemia (CMI), a severe form of coronary artery d...eople each year. A person who suffers from chronic myocardial ischemia continues to experience insufficient flow of oxygen-rich blood to the heart despite optimum...Researchers from the CIMA have discovered a possible cause of thrombosis
...n the treatment of young women who have suffered a myocardial infarction or who have suffered multiple miscarriages due to thrombosis in the placenta. Research is continuing concerning other pathologies, where the biological basis of the disease is thrombosis, such as strokes and pulmonary embolisms. In the fut...Top scientists meet for Global Conference on Stem Cell Therapy for Cardiovascular Diseases
...ature an in-depth view of cell-based therapies for myocardial repair and regeneration, and cutting-edge research... for the discussion of heart attacks (ST elevation myocardial infarction, or STEMI) and congestive heart failure (CHF). Each will cover the essential topics of h...Getting to the heart of the heart
... single cardiac progenitor cell gives rise to both myocardial cells, which form the beating muscle and electrica...es rise to the right-sided heart chambers, forming myocardial cells, smooth muscle cells, and endothelial cells. Since these different cell types were thought to...Tβ4 is essential for coronary vessel development report
...ere as a single factor that can potentially couple myocardial [heart] and coronary vascular regeneration in fail...oming of current angiogenic therapy in response to myocardial ischemia in humans is that the outcome may be limited to capillary growth without concomitant collat...Two drugs may stabilize plaques in atherosclerosis
... for the prevention of coronary artery disease and myocardial infarction (heart attacks), atherosclerosis remains the most common cause of disease-related death in the Western world and in developing countries," he said....Patients respond well to first study to test higher doses of an anti-cancer drug
...pain, headache, inflamed pancreas, hypotension and myocardial infarction. Dr Lorigan said: "In general, the study drug was well tolerated, particularly when compared to standard chemotherapy. There was no clinically significant myelosuppression, most probably because the immunoconjugate is targeted at the tum...SNM: Exploring molecular imaging potential
... of recurrent or residual disease, restaging), for myocardial perfusion (coronary artery disease, myocardial viability), and for neurology and neurosurgery (brain tumors, medically intractable epilepsy, stroke...'Sewer gas' induces suspended animation without decreasing blood pressure
... sulfide reduces metabolic rate without depressing myocardial function, we may be able to reduce metabolism and protect organs without using hypothermia." One caveat to this research so far is that hydrogen sulfide might produce this result in mice and other naturally hibernating species much more readily...Rescuing injured hearts by enhancing regeneration
...the heart to regain its function after a simulated myocardial infarction. The study will appear in the October 17 issue of the Proceedings of the National Academy of Sciences (posted online during the week of October 9). Normally, after a heart attack, the damaged heart muscle cannot grow back and is instead ...Stress imaging tests predict prognosis of heart disease in obese persons
...ssue of the Journal of Nuclear Medicine. "Stress myocardial perfusion imaging (or stress testing)--with better...e and expensive procedure," Elhendy noted. "Stress myocardial perfusion imaging--with 99mTc-tetrofosmin--can effectively risk stratify obese patients and guide th...SNM honors outstanding contributors
...ion of PET-based techniques for measuring regional myocardial blood flow in absolute units using 13N-ammonia. Schelbert, who was previously awarded SNM's Georg Charles de Hevesy Nuclear Pioneer Award for his distinguished contributions to nuclear medicine, has edited several books on cardiovascular imaging, ...Erectile dysfunction: Incidence rate linked to type and severity of coronary artery disease
...o have acute coronary syndrome (ACS), mainly acute myocardial infarction with one blood vessel affected for exa...patients admitted to the hospital because of acute myocardial infarction who were found to have ED (a few simple questions by the doctor are enough to make a corr...Growth factor triggers growth of new blood vessels in the heart
...patients suffering from ischemic heart disease and myocardial infarctions and offer an alternative to invasive procedures like surgery or angioplasty. About 12 percent of heart patients are not eligible for bypass surgery, which redirects blood around clogged arteries, or for other procedures routinely used to...Adult stem cell research at UB targets damaged hearts
...s -- into the down-regulated tissue can change the myocardial adaptive responses and improve the function of the hibernating myocardium. "My colleagues and I already have carried out initial stem-cell transplantation studies with promising results," said Lee. "Additional studies will be needed to determine wh...Novel non-invasive imaging technology may allow precise diagnosis of coronary artery disease
...uch as patients with diabetes or with a history of myocardial infarction and patients who have had bypass graft surgery, he added. Technological issues that need to be addressed and evaluated include assessment of improved CT technology (64 slices vs. the current 16 slices) and SPECT technology (shorter acquisi...When it counts: Shortening imaging time for individuals with suspected heart problems
....--Researchers discovered that the time spent on a myocardial perfusion single photon emission computed tomograp.../nuclear medicine procedures as well," he added. A myocardial perfusion SPECT imaging study--also called a cardiac stress/rest test--helps evaluate a patient's he...