Research team develops nonhuman primate model of smallpox infection
...hat closely resembles human disease, which will be necessary for testing of future vaccines and potential treatments. The study, published in this week's online early edition of Proceedings of the National Academy of Sciences , is the first to demonstrate that variola virus, the causative agent of smallpox, c...Stanford researchers establish center for physics-based simulations of biological structures
...ata from the real world to provide the constraints necessary to drive and validate models and simulations. The problems under investigation are all currently existing peer-reviewed projects: RNA folding, which has implications for rheumatological diseases (principal investigator Dan Herschlag); myosin dynamics...New biomaterials improve medical devices
...nd materials, thus reducing the amount of lab work necessary to develop a new material for a specific application. Among the clinical applications that will be discussed on the second day are drug-eluting cardiovascular stents, orthopaedic tissue engineering to repair or replace bone, and scaffolds that p...Annals of Internal Medicine tip sheet for Oct. 5, 2004
... actions may have contributed to death: not taking necessary preventive medicines; not following the prescribed regimen for the medications, or not seeking medical attention promptly (within two days) when symptoms occurred. For 70 of the 105 deaths (66.7 percent), medical errors may have contributed to the...New Military Biomaterials R&D Center to hold first meeting
...BMR will form research partnerships to develop the necessary technologies. The U.S. Army's Telemedicine and Advanced Technology Research Center at Fort Detrick, Md., is the program office for the CeBMR. The new center has already established partnerships with the U.S. Army Institute for Surgical Research, the...U-M scientists see ubiquitin-modified proteins in living cells
...Kerppola says. "It tags Jun with ubiquitin, and is necessary for the protein to be targeted to the lysosome." If Itch doesn't recognize Jun, Kerppola explains, the level of Jun builds up in the cell, which can alter the regulation of gene transcription and cell growth. "Applying ubiquitin-media...Component of volcanic gas may have played a significant role in the origins of life on Earth
...hing done by DNA today), carried out the chemistry necessary for life, and formed the essential physical structures of life (something done primarily by proteins today). But how did that RNA world come about? "Anybody who thinks they know the solution to this problem [of the origin of life] is deluded...Researchers provide road map for generating B cells from stem cells
...surface, such as Flk2 followed by IL-7R, which are necessary for receiving subsequent external signals. In the next step, the gene for a regulatory protein known as E2A cooperates with PU.1 to activate another regulatory gene called EBF. EBF and E2A act together to push the lymphoid progenitor towards stage 3...Mitochondria findings may help beat wide range of disease
...daughter" cell the full complement of mitochondria necessary for healthy cell physiology. Recent research sugge...hondria contain within themselves all the proteins necessary for fusion. This stands in stark contrast to the process of single-membrane fusion, which requires m...Time-lapse movies show brain cells move like a two-stroke engine
...ted movement of the centrosome and the nucleus are necessary for migration." "As many signaling pathways in the young neuron could talk to the Par6 signaling center, it is likely that discovering those signaling networks will lead us to novel classes of cell surface receptors that regulate migration, and there......h osteoarthritis, suggesting that BMP signaling is necessary for the maintenance of healthy articular cartilage. This raises the possibility that mutations in BMP signaling components may underlie some of the genetic variation in human osteoarthritis risk and suggests that treatments designed to mimic or augme...New DNA repair enzyme makes mistakes to save lives of cells
... is a double-stranded molecule that contains genes necessary for the production of proteins, which in turn dete...d, our impression of POL-Q is that it does what is necessary when emergency measures are required. One analogy would be duct tape, which in a pinch can be used t...ENCODE consortium publishes scientific strategy
...rtain stages of development, which means it may be necessary to analyze many different types of human cells. In addition, if a truly comprehensive inventory is to be created, more work needs to be done to learn about functional elements not surveyed in the pilot project, including centromeres (the middles of c...Nitric oxide is essential for animal development
...ained an open question whether NO is also actually necessary for animal development. This uncertainty was mainly due to the fact that the mammalian genome encodes three NOS genes with partially overlapping function; because these genes may compensate for each other if one of them is mutated, an essential func...Yerkes researchers to present array of new data at Society for Neuroscience Meeting
...ressin receptor in a specific area of the brain is necessary and sufficient for normal social recognition in mice. This study illustrates the importance of the gene therapy and transgenic technology as effective and innovative tools for investigating the behavioral effects of gene expression in certain areas o...UCSD biologists discover chemical important in guiding visual system development
...se drugs interfering with the spontaneous activity necessary for patterning the developing nervous system." A previous study by Feller and her colleagues showed that the pattern of neural activity is essential for the retinal ganglion cells--which extend projections from the retina to the brain--to fo...UCLA and Univ. of Utah researchers identify how a hormone regulates iron
... of Medicine at UCLA. "We knew that ferroportin is necessary to help release iron into the bloodstream, but didn't know that hepcidin directly regulates this activity." Ganz adds that too much hepcidin present in the body -- which can occur in patients with infections or with inflammatory diseases such as rheu...Research to explore revolutionary gene sequencing: Threading the molecular needle
...of accurate sequencing of specific tissues that is necessary to understand many of particular genetic problems of individual patients. A radical new method of DNA sequencing currently being explored by Stuart Lindsay, Director of the Center for Single Molecule Biophysics in the Biodesign Institute at A...Is the zebra fish leading us to new therapies?
...our body. They form a kind of network to bring the necessary nutritional and building materials to organs and tissues and to carry off waste products. So, it is difficult to overstate the importance of blood vessels to a well-functioning body. Disorders in which the blood supply is impaired are quite serious: ...Bristol scientists find key to unlock body's own cancer defence
...the United States. New blood vessel growth is also necessary for many normal body functions. These include the development of the embryo and, in adults, wound healing, the development of the placenta in pregnancy and of muscles during physical training programmes. However, it is thought that adults can live he...