New data demonstrate that Benicar and Benicar HCT significantly reduces systolic hypertension
...derived drugs. No initial dosage adjustments are necessary with BENICAR in elderly, in moderate to marked renal impairment (creatinine clearance In clinical trials, the withdrawal rates due to adverse events (AEs) were similar with BENICAR and BENICAR HCT to placebo: BENICAR (2.4% vs 2.7%); BENICAR HCT (2....MSKCC researchers uncover structure of key protein complex in cells
... important in cancer, research suggests that it is necessary for the normal assortment of chromosomes immediately before a cell splits. Yeast cells that lack SUMO cannot successfully divide, Dr. Lima noted. Since cancer is characterized by cells dividing unchecked, proving SUMO's function could potentially yi...Single gene is genetic switch for fly sexual behavior
...uitless as a behavioral "switch gene" that is both necessary and sufficient to produce a particular behavior. Switch genes that trigger the development of a particular anatomical feature like wing structure have been studied extensively, but there are very few studies of switch genes that control a complex beh...Dinosaur fossil bone leads to gender, age determinations
...els, and the temporary tissue provides the calcium necessary to form eggshells. Medullary bone is only found in present-day female birds; no other egg-laying species including crocodiles, the other living dinosaur relative produces this tissue naturally. Because the dinosaur tissues didn't look exactly like...Scientists create digital bacteria to forge advances in biomedical research
... which is equipped with all the virtual components necessary to search for food. These digital E. coli contain their own chemotaxis system, which transmits the biochemical signals responsible for cellular locomotion. They also have flagella, the whiplike appendages that cells use for propulsion, and the motors...New research provides evidence that Rh proteins act as CO2 gas channels
...h levels of carbon dioxide, suggesting that Rh was necessary for the algae's ability to benefit from high CO2 levels. In this new study, Kustu and her research team isolated strains of C. reinhardtii in which an Amt gene was inactivated. They found a 90 percent reduction in uptake of the ammonia analogue methy...Chemical that triggers hibernation may protect muscles
...ascular or reconstructive surgery, it is sometimes necessary to block blood flow, which may cause tissue damage. This problem might potentially be alleviated if a pharmacological substance was able to achieve IP. Hibernation in mammals is thought to confer cardiac benefits similar to IP. Researchers led by Jin...Monkeys understand numbers across senses
...modalities, and this tells us that language is not necessary to represent number abstractly," she said. "When we humans apply the word 'three' to sounds or visual images, we're using language to link these different sets from different modalities. And the question has been whether an animal without that kind o...NC woman is now insulin-free after series of three islet cell transplants
...as that determine the body's need, and release the necessary amount of insulin to maintain normal blood sugar levels in the body. In Type 1 diabetes, the pancreas does not produce that insulin, forcing patients to inject insulin every day. Type 1 diabetes carries with it increased risks of kidney failure, nerv...Temple engineers recieve NSF grant to develop interactive high school biology curriculum
...e scientific inquiry skills and reasoning patterns necessary for the reconstruction of past events, said Butz, who is a professor of electrical and computer engineering at Temple. The first scenario presents students with a murder investigation where they are charged with the responsibility of identifying susp...Study in Royal Society journal on heritability of female orgasm
...ar. To interpret such "time-series it is generally necessary to assume that any trends seen result from growth and death at that location, not from populations produced elsewhere being swept through the site by currents. Our results demonstrate that for some of the smallest (but most important globally) plankt...Unweaving amyloid fibers to solve prion puzzles
...iber. To understand the nature of this fiber, it's necessary to understand how the prions that comprise it attach to each other. Krishnan was able to identify the precise segment at which the prions interact--something that no one had done before him with a real prion. To do this, Krishnan took a variety of y...Researchers get first peek at amyloid's spine
...a Balbirnie had narrowed down the stretch of prion necessary for fibrils to only seven amino acids, which were located at one end of the entire protein. Filling a test tube with just those snippets was enough to form short thin threads with the same essential characteristics of the common amyloid spine, a stru...Deadly infectious entity of prions discovered
...hether the flat shape of the beta-sheet itself was necessary for a prion to be infectious. The Salk team found that destroying the shape of the beta-sheet rendered the prion harmless. It was no longer able to spread throughout the fungal cell and "tag" other prions, causing them to become infectious. This r...Researchers create infectious hepatitis C virus in a test tube
...o CD81, and they believed that this interaction is necessary for the virus to bind to target cells. The Rockefeller researchers showed that CD81 molecules that are not attached to the surface of host cells compete with membrane-bound CD81 and inhibit entry of HCV into the cell. They also showed that HepG2 cel...Discovery suggests why stem cells run through stop signs
...tiny bits of genetic material called microRNAs are necessary for stem cell division to take place, suggesting that microRNAs shut off the signals that stop cell division in most other cells. The findings were published online this week by the journal Nature . In the paper, the researchers also speculate that...New study demonstrated add-on effects of ACTOS (pioglitazone HCl)
...3.8 μmol/L, and mean levels of Apo A1, a component necessary for HDL-C metabolism and biosynthesis, increased by 9.7 mg/dL. LDL/VLDL: Mean LDL particle size increased 0.23 nm and mean LDL particle concentration decreased 189 nmol/L, indicating there were fewer LDL particles and they were larger and more bu...MicroRNA tweaks protein that controls early heart development
...lopment of heart muscle. "We think that Hand2 is necessary in the early stages of embryonic development to allow proliferation and expansion of a pool of muscle progenitor cells that can eventually develop into the heart," said Dr. Deepak Srivastava, senior author of the paper. "But at some point production ...U. Iowa finding speeds up immunization booster schedule
...ster vaccination or a second infection. Thus it is necessary to allow for this "lag time," in which the memory T cell population develops, before giving a booster shot designed to bump up immunity. The DC vaccination strategy used by Harty and his colleagues involved "arming" dendritic cells against a specifi...Mass production of human papillomavirus could lead to gains against cervical cancer
...ong known that the HPV capsid proteins, which were necessary for virion formation, could self-assemble. Also, said Ahlquist, John Schiller and his colleagues at the National Institutes of Health recently found that by introducing the genes for these self-assembling capsid proteins into cells along with smaller...