Doctors link common chemotherapy drug to jawbone necrosis
...al strength of the bone. Bone remodeling is like a necessary game of tug-of-war between the goods guys and the bad. Bone mass and mineral content constantly adjust throughout the life cycle to support the places on the skeleton where the most outside force occurs. Novartis's Aredia (pamidronate disodium) ...Europe's fishermen should have marine 'stewardship' role, says study
... also be about ensuring they are equipped with the necessary knowledge, tools and incentives to discharge this responsibility on behalf of society." Barrie Deas, chief executive of the National Federation of Fishermen's Organisations, said: "We welcome the balanced approach evident in the FEP, and particularl...New effects of an antihistaminic against cerebral injury
... the brain, but to facilitate treatment it will be necessary to find a way in which the drug can be administered by oral route. The following people participated in the research: Cristina Malagelada, Josefa Sabri, Jos Rodrguez, Xavier Xifr and Nahuai Badiola. They are all researchers at the Institute of Neuro......et off in response to certain signals and which is necessary for the regeneration of tissue and for growth. This stop code is usually set off by chemical messengers, but can also be triggered by damage caused to the cells. Stefanie Dimmeler has studied the fundamental processes of vascular cell damage and rege...Emory biochemist writes lead essay describing Nobel Prize research on ubiquitin protein
...inated when they become defective or are no longer necessary for a particular cell. Last week Dr. Rose, now at the University of California, Irvine, was one of three scientists awarded the Nobel Prize in Chemistry for the discovery of "ubiquitin-mediated protein degradation." The other two scientists were Avr...Your brain and you: Forecasting the ethical challenges ahead for neuroscience and society
...s or even electronic brain enhancements become the necessary edge for students and workers? "One problem with brain enhancement, if it becomes widespread, is that puts pressure on everyone to enhance," Farah said. "American courts have already heard cases brought by parents who were coerced into medicating th...Combined stem cell-gene therapy approach seen as potential treatment for cystic fibrosis
...ulates the intake and secretion of salts and water necessary for cellular function. If the CFTR gene were not functioning properly, the chloride taken in by the cell would not be able to besecreted. Yet, as the authors reported, the CFTR-corrected stem cells secreted significantly more chloride than stem cells...Potent anticancer drug increases function of axons in mouse model of neurodegeneration
...ompounds, say the researchers. However, it will be necessary to find microtubule-binding drugs that can cross the blood-brain barrier, where they can exert their beneficial effects on nerve cells inside the brain. Penn coauthors are: Sharon Shively, Jennifer Bruce, Edward B. Lee, Sharon X. Xie, Sonali Joyce,...Researchers discover a stem-cell switch lurking within leukemias
...athway -- outlined in their new studies -- will be necessary to cure chronic myeloid leukemia. The researchers, led by Gary Gilliland , a Howard Hughes Medical Institute investigator at Brigham and Women's Hospital and Harvard Medical School, published their findings in the December 2004 issue of the journal ...Weizmann Insitute scientists show how proteins beat the evolutionary stakes
... evolutionary terms. "Two contradictory things are necessary for the survival of organisms," he says. "First of all, an organism needs to be robust in the face of mutation it needs to undergo as little change as possible in its functioning in spite of mutations. But, evolutionary adaptation requires some mut...Tips from the Journals of the American Society for Microbiology
... causing disease as it is missing two of the genes necessary for replication and it stimulated a stronger immune response in both animals. "Given its efficacy, its defectiveness for latency, and its ability to induce rapid, virus-specific CD8+-T-cell responses, the dl5-29 vaccine may be a good candidate for e...Hospital epidemiologists trace outbreak of organism to commonly used wound care equipment
..., or source, of infection and putting in place the necessary steps to prevent an outbreak from happening in the first place." The investigation began with an immediate review of medical records after an initial cluster of five patients became infected with the bacteria, a five-fold increase from previous month...Chromosome 16 publication fulfills DOE's human genome commitment
...n international team of researchers to collect the necessary resources, develop groundbreaking technologies, and propel the nation in an epic quest to map and sequence the human genome....Immune system contributes to evolution of a new fluorescent protein
...bulin genes, producing a large array of antibodies necessary to attack microbes and other foreign substances that the immune system may never have encountered before. The researchers said their demonstration that SHM can be widely adaptable for research use opens the way for enormously faster mutation of genes...UCSD discovery shows how embryonic stem cells perform 'quality control' inspections
...es the expression of a gene called Nanog, which is necessary for the self renewal, or unlimited duplication, of these stem cells. The suppression of Nanog promotes embryonic stem cells to differentiate into other cell types. "The end result of all of these actions by p53 is to deprive embryonic stem cell...Evidence that human brain evolution was a special event
... involved in "housekeeping" functions of the brain necessary for neural cells to live and function. If intensified selection indeed drove the dramatic changes in the size and organization of the brain, the developmental genes would be expected to change faster than the housekeeping genes during human evolution...University of Chicago researchers discovered that humans are a 'privileged' evolutionary lineage
...of 95 genes, which are involved in basic functions necessary for each cell in the body to survive. "If there is something inherently different about humans in the evolution of their genes not related to selection the control genes should reveal it too. These basic, conserved genes are the last to change," Va...Growth of common skin cancer blocked in gene-switch mice
...archers found that sustained expression of Gli2 is necessary for the continued growth of these tumors. When Dr. Dlugosz and colleagues turned Gli2 off, the BCC tumor cells stopped growing and were eliminated via execution of a programmed cell death process. These results are consistent with previous work from...$6.7 million for bionic war on disabilities
... a "smart" wireless electrode array so it won't be necessary for people using the device to have 100 wires emerging from their skull, something that raises the possibility of infection and also of getting the wires snagged while the person is using a wheelchair, Normann says. "To go from a bundle of wires......duate and graduate researchers, and some equipment necessary to carry out this work. Dr. Carroll's research, since 1993, has focused on the molecular mechanisms that regulate fertilization. He earned a doctoral degree from the University of Connecticut Health Center in 1996....