International gathering of scientists looks toward future of cancer research
...very nature, has a front, middle, and end. Each is necessary and each is interdependent. "At this Annual Meeting, scientists from basic, translational and clinical research will exchange information and learn from each other with the understanding that each has an essential role and each has a common mission: ...PNAS highlights for the week of April 11 - 15
...on the actions of largesets of neurons, it becomes necessary to determine how these cells work together to allow memories to form. Joe Tsien and colleagues simultaneously recorded the electrical activity of up to 260 individual neurons of the mouse hippocampus, the brain structureresponsible for forming memo...Unconventional brain circuits offer clues to insomnia-obesity connection
...hypocretin system to small stimuli would have been necessary for survival," he said. "But in today's chronically stressful environment, the circuitry may also be an underlying cause of insomnia and associated metabolic disturbances, including obesity."......on alert so it can focus its cameras and sound the necessary alarms, helping human guards better protect their perimeter. The Smart Sensor Enabled Neural Threat Recognition and Identification (SENTRI) system from Safety Dynamics, Oak Brook, Ill., incorporates software developed by Dr. Ted Berger at the Univers...Scientists use transcription factors to increase insulin production in diabetic mice
...sed to deliver genes into humans. Thus, it will be necessary to modify the vector or to develop some other technique to deliver the transcription factor genes into humans....Report proposes structure for national network of cord blood stem cell banks
...nizations have developed several of the components necessary to manage daily coordination of banking and alloca...large scale, no organization currently has all the necessary capabilities to serve as the Cord Blood Coordinating Center, the committee concluded. HRSA official...New study explains process leading to many proteins from one gene
...from your version, just a different cookie. Omit a necessary ingredient, such as flour, and you'll have a mess (nonfunctioning or malfunctioning protein). Similarly, the information in genes is not directly converted into proteins, but first is copied by special enzymes into RNA, or more specifically, pre-mes...Joining hands to solve a DNA replication problem
...ed, allowing various enzymes access to the DNA for necessary processing. Fanning and Chazin have developed a working model to answer that question. Using SV40 as a model system, the scientists mapped atomic level interaction on the surfaces of proteins involved in DNA processing. They used biochemical and gen...Readers of genome decipher signatures of cancer patient outcomes
...by itself." MTHFR includes the genetic information necessary for cells to generate an enzyme essential in the folic acid, or vitamin B9, metabolic pathway. The variant alleles of both SNPs result in reduced MTHFR enzymatic activity. Reduced MTHFR activity increases the amount of folate in tumor cells. The p...Gene associated with breast cancer may play major role in prostate cancer recurrence
...his work, he added, is that HER-2 is important and necessary for prostate cancer viability and progression. "This provides the rationale for initiating a clinical trial of this novel drug inhibiting HER-2, which is being planned for patients within several months," Whang said. "I envision this drug becoming on...Strongest proof yet found for prion hypothesis
...e to produce the large quantities of prion protein necessary for the success of the experiments and opened the door to further TSE studies. According to Soto, it should also soon facilitate creating a much-needed blood test for prions, which would greatly improve current surveillance techniques for mad cow dis...UCLA researchers discover new method to generate human bone
...ate healing in those patients who lacked normal or necessary bone formation," Ting said. "This discovery will provide another option for patients. Competition will make treatment options safer, less expensive and more accessible for those families who really need it." The team of UCLA researchers, under the bu...National Academies news: Stem cell guidelines released
... ask fertility doctors to create more embryos than necessary for reproductive treatments. According to the guidelines, donors should be told that information about them, including their names, may be retained and could become known by those who derive or work with resulting stem cell lines, but that donors' id...Improved cancer treatments aim of new biology research program
...leled. We need to think big, and we have found the necessary support here. There is a wonderful collaborative environment, and the potential to mix theory and experiment is very good." Dr. Kauffman has received an iCORE Chair and Professor Establishment grant of $850,000 per year for five years, plus a $300,...USC researchers determine mechanism of action of chemotherapy drug
...lism and alteration of key enzymes and metabolites necessary for normal cell function." Thus, the researchers noted, the use of MGd leads to the death of cancer cells via disruption of critical enzymes needed for cell survival and replication. "We have increased the understanding of this drug's mechanism of ac...Major advance made on DNA structure
...ding DNA structure, the scientists say, is just as necessary as knowing gene sequence. The human genome project, with its detailed explanation of the genetic sequence of the entire human genome, is one side of the coin. The other side is understanding how the three-dimensional structure of different types of D...JCI table of contents May 2, 2005
...ave abnormal protein expression of FOXP3, a factor necessary for these cells to function properly. The resulting defective function of the cells allows them to proliferate abnormally causing the HTLV-1 associated disorders. In an accompanying commentary, Robert Fujinami also points out that "the lack of supp...The clustering of Hox genes is not necessary for their proper function
... the fruit fly, the clustering of Hox genes is not necessary for their proper function. The fruit fly Drosophila is not the only exception to the rule of ordered arrangement of Hox genes. Some worms and marine invertebrates also show breakages of the Hox gene complex. What do these organisms have in common wi...Wild grasses and man-made wheats advance research capabilities
...s to bring in the genetic variability I believe is necessary for thegene pool here." Karnal bunt, new races ...A series of crosses back to the hexaploid wheat is necessary before thedesired trait from the wild species is expressed without any geneticabnormalities. The ......issherbst. The authors show that ferroportin 1 is necessary for normal iron cycling. The article provides evidence for conservation of function of ferroportin1 and establishes the zebrafish as a useful model organism for the study of hemochromatosis....