Omega-3 fatty acids affect risk of depression, inflammation
...e study and tested for interleukin-6 (IL-6), tumor necrosis factor -alpha (TNF-alpha ) and the receptor molecule for IL-6. Participants also completed a survey questionnaire that gauged their level of depression. The analysis showed that participants who had much more omega-6 -- compared to omega-3 -- fatty...JCI table of contents: May 24, 2007
...and able to reduce the extent of pancreatic tissue necrosis in the rela mice. The results provide evidence of a role for RelA/p65 in the protection of pancreatic acinar cells against cell death, via the upregulation of PAP1. Together, the two studies identify the IKK/NF-kappaB pathway in acinar cells as being...Ethanol injection helps manage bone metastasis in thyroid cancer patients
...explained Nakada. "Absolute ethanol induces direct necrosis (cell death) of the tissue in the area where it is distributed. Therefore, if absolute ethanol is selectively injected into a malignant tumor, selective destruction of the tumor may be expected," he added. In their study, 12 patients with radioiodine...Latest data shows MabThera provides significant, sustained relief from symptoms of RA
...nadequate response to treatment with either tumour necrosis factor (TNF) inhibitors or disease-modifying anti-rheumatic drugs (DMARDs), both of which are commonly used classes of RA drugs. All study patients received multiple courses of MabThera (2 x1000mg infusion, 2 weeks apart) based on disease activity. ...JCI table of contents: June 14, 2007
... excessive immune response to infection. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been previously reported to play a role in the regulation of the host immune response. In the current study, Joerg Weber and colleagues administered components of Streptococcus pneumoniae bacteria ...Cytokine resistance contributes to pathology of type 2 diabetes
... within the cell. Interleukins, interferons, tumor necrosis factors and some growth factors are among the cytokines that direct many aspects of the immune response. Cytokines are secreted by many types of cells, including the immune cells known as macrophages. In earlier studies, the researchers had shown t...Hot on the TRAIL of controlling inflammation in bacterial meningitis
... excessive immune response to infection. The tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) has been previously reported to play a role in the regulation of the host immune response. In the current study, Joerg Weber and colleagues administered components of Streptococcus pneumoniae bacteria ...Omega-3 fatty acids protect eyes against retinopathy, study finds
...ppress a type of inflammatory protein called tumor necrosis factor alpha (TNF-alpha). TNF-alpha is found in one type of cell, called microglia, that can be closely associated with retinal blood vessels. The retina has one of the highest concentrations of omega-3 fatty acids in the body, said lead author an...Rapid evolution of defense genes in plants may produce hybrid incompatibility
...uly 11, 2PM). Bomblies and Weigel observed hybrid necrosis in crosses of thale cress, Arabidopsis thaliana, a...erely defective. They call this phenomenon hybrid necrosis or hybrid weakness, and identified the gene responsible for the incompatibility as a disease resista...Scientists follow familiar TRAIL to new cancer therapy
...enhancing the potency and effectiveness of a tumor necrosis factor (TNF) death receptor ligand against a variety of human cancers. Potency and lack of toxicity to normal tissues make activation of TNF-a-related apoptosis-inducing ligand (TRAIL) death receptor signaling an attractive and exciting target for...JCI table of contents -- July 26, 2007
...ical to the development of progressive hemorrhagic necrosis following spinal cord injury, and as such may cons...C[Ca-ATP] channels mediate progressive hemorrhagic necrosis following spinal cord injury AUTHOR CONTACT: J. Marc Simard University of Maryland at Baltimor...JCI table of contents: Aug. 9, 2007
...icle.php?id=30380 CARDIOLOGY: Cell death by necrosis leads to heart failure The prevalence of heart...inical Investigation, indicates that cell death by necrosis also has a role in the cardiomyocyte loss that accompanies heart failure in mice. In the study, Je...NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
...nts with an inadequate response to anti-TNF (tumor necrosis factor) agents. In this study, rituximab is considered to be experimental because it is not FDA approved for the treatment of dermatomyositis or polymyositis. The study doctors believe that the symptoms of myositis are related to the presence of B ce...