Study begins to reveal clues to the cause and progression of sepsis
...d be dangerous, since the inflammatory response is needed to address the underlying infection. Instead, they believe that therapies that address the chronic inflammatory response after sepsis and those that act more broadly on multiple components may yield better results. No one really knows why some pe...Features of replication suggest viruses have common themes, vulnerabilities
...eck is a gateway that appears to permit substrates needed for replication to enter and newly made viral genomes to exit. The virus begins to co-opt the cell as a critical viral protein and viral RNA localize to the budding organelles, Ahlquist explains. "The virus takes over most of the available membrane...Doernbecher Children's Hospital scientist earns coveted Javits award
...ow these oligo-cells to mature and make the myelin needed to restoregreater function to the damaged brain," Back said. Back is the second OHSU researcher to receive this highly covetedaward. In 2002 Edward Neuwelt, M.D., professor of neurosurgery andneurology, OHSU School of Medicine, Portland Veterans Af...Gene regulation, not just genes, is what sets humans apart
... macaque genome was published in 2005 because they needed a third, closely related relative to compare the regulatory sequences. The mouse genome had been used as a reference point for comparing the coding sequences of humans and chimps, but the non-coding sequences have generally evolved much faster. Mic...New, more direct pathways from outside the cell-to-cell nuclei discovered
...refore, his discovery means that "one less step is needed for extracellular material to get into the nucleus, and so it is far easier than previously thought for this material to get into the nucleus." Eve Barak, an NSF program director, describes Gavin's discovery as "an amazing and potentially paradigm-...Abnormal fat metabolism underlies heart problems in diabetic patients
...t in order to measure cardiolipin, the researchers needed a way to distinguish it from the numerous other lipids found in heart cells. Fortunately, Gross and his colleagues have been developing and refining a highly sophisticated set of techniques that allow them to separate and quantify thousands of differ...OHSU turns mouse into factory for human liver cells
...cadaver livers left over after high-quality livers needed for transplants are harvested. Plus, the cells are only available when specimens become available, which can be any hour of the day or night, and they must be used immediately. "There are a number of companies that take these leftover livers, proce...European Science Foundation's Forward Look reaches out beyond the endless frontiers
... Proactive risk assessment for nanomaterials needed Recommendations on commercial exploitation, ...terisation and standardisation) and the techniques needed to evaluate the potential risks of environmental, human exposure (accidental and purposeful) to the ...Grapes, soy and kudzu blunt some menopausal side effects
..., using other indices of these forms of memory, is needed before the effect can be fully interpreted. The researchers also tested the hypothesis that grape seed polyphenols reduced salt-sensitive hypertension in young, estrogen-depleted rats. After ten weeks on specific diets, grape seed supplementation s......ew technologies that provide essential information needed to characterize landscape dynamics. She will discuss the types of landscapes that are measurable using those instruments and examine how ecosystem functions related to biogeochemical cycling and landscape dynamics can be quantified. Gregory Asner ...Other highlights in the Aug. 7 JNCI
...h a high death rate. New prevention strategies are needed to reduce the number of deaths from the disease. Chen-Xu Qu, M.D., and colleagues conducted a randomized clinical trial that examined whether four vitamin-mineral supplement combinations could effect the liver cancer death rate in a Chinese popula......mote adoption of the practice, further research is needed to identify more cover crops that behave similar to sunn hemp and the low-cost sources of its seed. High seed cost is a limiting factor to more widespread use of this effective cover crop. Atrazine is also used globally resulting in numerous studi...UCF research links proteins, stem cells and potential Alzheimer's treatment
... more research, including clinical trials, will be needed should the next set of research benchmarks be met. Its one thing to be able to manipulate stem cells for creating specific tissue types the brain, the eyes, the heart but every disease is different, he said. Simply producing transplantable cells...In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
...ot sure why, but it may be because all the factors needed for transcription have to come together at the rig... have everything at the ready in case you suddenly needed to rev up transcription, says Dr. Singer. Once the paused polymerase starts up again, in a very shor...A sensory organ, not the brain, differentiates male and female behavior in some mammals
..." Dulac says. "Either the vomeronasal organ may be needed to grow a female-specific neural circuit during development, or the mature female mouse brain may require vomeronasal activity to repress male behavior." To test these two alternatives, Dulac and her colleagues excised vomeronasal organs from the n...Improved NIST SRM aids lead poisoning detection
...t of next generation clinical methods that will be needed to accurately measure blood lead levels in children as progress is made toward eliminating lead exposure. In addition to lead, levels two through four of SRM 955c contain added amounts of arsenic, cadmium, mercury, methylmercury and ethylmercury to...A low expression of MX2 gene exists in the white blood cells of narcoleptics
...colepsy has not been elucidated. Further study is needed to explore the functional relationship between the MX2 gene and narcolepsy and characterize the effect of interferons in narcolepsy. Narcolepsy is a sleep disorder that causes people to fall asleep uncontrollably during the day. It also includes f...COX-2 inhibitors delay pancreatic cancer precursors in mice
...e of pancreatic tumors, additional studies will be needed for researchers to conclude whether or not nimesulide can delay the onset of or prevent pancreatic cancer. With these results, I certainly wouldnt say everyone should be taking COX-2 inhibitors to protect against cancer, said Eibl. However, with ad...... the study. A new generation of anthrax drugs is needed because antibiotics given now to people exposed to anthrax spores, though they work, cause serious gastrointestinal effects during the 60 days people need to take them. Many people do not complete the full course of treatment. An improved drug would ...Einstein researchers' prototype vaccine could provide improved protection against tuberculosis
...o coinfection with HIV, the advance could herald a needed breakthrough against one of the worlds leading kil...g T-cell response against the bacteriajust what is needed from an effective TB vaccine. Our secA2 mutant TB vaccine elicited protective immunity that was me...