Commandeering cellular machinery: recognition mechanism to detect small molecules
...tested in parallel a task akin to finding genetic needles in thousands of haystacks simultaneously. Using the technique, the researchers placed each variant, which had been inserted into yeast cells, onto petri plates containing LG335. A small number of yeast cells (less than 0.1 percent of the total) gr...Report: How 10 top new technologies will help world reach globally-agreed goals by 2015
...and vaccine delivery methods that avoid the use of needles and reduce cross contamination; Bioinformatics to identify drug targets and to examine pathogen-host interactions; Nutrition-enriched crops to counter specific deficiencies, such as vitamin A-rich "Golden Rice" to improve health for millions with...Gene therapy approach reverses diabetic neuropathy in animal model, Pitt study finds
...d by such symptoms as numbness, tingling, pins and needles or loss of sensation, most often to the legs and feet. As a result, patients may be unaware of the presence of ulcers or infections or that they've experienced injury. No treatments exist that can stop progression of neuropathy, let alone reverse any...UO study is first to link histamine receptors to heat stress
...during heat stress. "I personally don't like needles but it's a very powerful technique to study skin blood flow," says Wong, who knows firsthand what the subjects will experience, having tested the technique on himself. A water-perfused suit is designed to tightly control skin temperature. The s...How the sea urchin grows new spines
... exists." The captured images show microscopic needles that grow first straight out from the stump of the old spine, and then branch out to form a lacy structure that is hard but light. The crystalline structure of the old spine provides the template for the alignment of the molecules in the crystal, an...US trees affected by growing number of health concerns
... new hosts. White pine blister rust enters through needles and bark and forms cankers on the branches and trunks, eventually causing death. Rare pines in fragile ecosystems are now threatened by this disease. Plant pathologists use a variety of methods to manage these and other tree diseases, but...Needling chromosomes yields insights into cell division
.... -- By impaling individual chromosomes with glass needles one thousandth the diameter of a human hair, a Duk...e high art of manipulating two infinitesimal glass needles to impale each of two sister chromatids in cultured grasshopper cells at the appropriate time in cel...Spit, and call me in the morning
...collect, since spitting into a cup doesn't require needles and can be done while a doctor or drug tester watches. As the panelists explained, researchers are making progress in both developing the technology for testing saliva and identifying the molecules, or "biomarkers," that reveal disease. Saliva testi...Dysentery uses 'sword and shield' to cause infection
...ace of the bacteria are shortened. This allows the needles to inject proteins, while protecting the bacteria from being destroyed by the immune system. Dr Tang adds: "This discovery greatly expands our understanding of how bacteria are sometimes able to evolve although it is unlikely to result in new treatm...Pulsating ultrasound enhances gene therapy for tumors
...current, are limited to surface lesions or require needles to be inserted in the body. Pulsed-HIFU is non-invasive and can treat any area of the body accessible by ultrasound, the exceptions being the lungs and bones. Additional advantages of pulsed-HIFU include no scarring, limited blood loss and infections...Marine sponge yields nanoscale secrets
...he tissue you're left with a handful of fiberglass needles as fine as spun glass or cotton. This primitive sk...covered that the center of the sponge's fine glass needles contains a filament of protein that controls the synthesis of the needles. By cloning and sequencing...Landmark comparative genomics study highlights the importance of 'junk' DNA in higher eukaryotes
...n and other vertebrate genomes is like looking for needles in a haystack," explained Siepel. "By focusing on conserved elements, you get a much smaller haystack. It's not guaranteed to have every needle in it, and not everything in it is a needle, but you're much more likely to find a needle if you look in...How do you spell recognition? C-O-R-E-C-E-P-T-O-R
... through the proverbial haystack to find those few needles and match up their T-cell receptors with the correct MHCantigen. This is where they turn to a completely separate set of proteins called the coreceptors. These coreceptors -- including CD4, a coreceptor displayed by helper T cells and CD8, a corecep...High carbon dioxide levels spur Southern pines to grow more needles
...arbon dioxide expected by mid-century produce more needles than those absorbing today's levels of the gas, ev... elevated CO2 had on average about 17 percent more needles than untreated pines. Higher needle percentages in trees receiving the gas were recorded even during...Lethal needle blight epidemic may be related to climate change
...othistroma septosporum, causes trees to lose their needles and, in the case of the British Columbia outbreak, eventually die. D. septosporum has long been recognized as a pathogen of pines, but although it is considered a serious disease of exotic plantations in the Southern Hemisphere, it has until now been......e will be presented that helps researchers to find needles of insight in haystacks of data generated by bigger and better facilities to probe matter with intense particle or X-ray beams. The e-Materials project has predicted a previously unidentified crystal structure, or polymorph, of a drug molecule. Arc...Materials scientists get the whole picture with new e-Science technique
...e-Science Programme is helping researchers to find needles of insight in the haystack of data generated by bigger and better facilities to probe matter with intense particle or X-ray beams. Dr Lakshmi Sastry will present the work at the e-Science All Hands meeting in Nottingham on Monday 19 September. Dr Sa......d predicting where they fit in is like looking for needles in haystacks." Or like looking at a line of automobiles and trying to decide which one a bulky motor fits into versus trying to find where a tiny screw goes. Linear motifs are so small that it is hard to tell what features allow them to bind to othe...Student scientists create living bacterial photographs
...h a laser, we can manipulate their biology without needles or syringes," says Tabor. "We just turn it on or off with light." Other students and researchers who participated in the project were Laura Lavery, Zachary Booth Simpson, Matthew Levy, Eric Davidson and Alexander Scouras. Faculty advisers were Elling...Study details hepatitis C ability to block immune system response
...se of unscreened blood transfusions, and re-use of needles and syringes that have not been adequately sterilized. Viral infections like hepatitis C often trigger an immediate innate immune response involving release of type 1 interferon (IFN-? and IFN-?). In turn, type 1 interferon stimulates the production...