Tag: "neurodegenerative" at biology news
An embryonic stem cell model for Parkinson's disease
... long been associated with neuronal cell death and neurodegenerative
diseases like Parkinson's. Proving a causal relati...odel for both studying the molecular mechanisms of neurodegenerative
disease and screening potential neuroprotectant drugs. The authors are hoping to extend their work t...
Irwin Rose wins 2004 Nobel Prize in Chemistry
...eins are regulated by degradation. Cancer and some neurodegenerative
diseases are thought to be related to disruptions in this pathway. From the work of Rose, Ciechanover and Hershko, it is now possible to understand at the molecular level how modification by attachment of ubiquitin results in breakdown of unwante...
FSU scientist links iron imbalance to Parkinson's disease
...es, which are associated with neuropsychiatric and neurodegenerative
diseases, affect the molecular mechanisms that regulate gene expression." Levenson performed the mouse model portion of the study in collaboration with Mark Mattson, Laboratory of Neurosciences chief at the National Institute on Aging in B...
Mitochondria findings may help beat wide range of disease
...wide range of diseases, including some cancers and neurodegenerative
diseases such as Parkinson's and Alzheimer's. Rese...inson's and Alzheimer's diseases (which arise from neurodegenerative
cell death), and evento some types of cancer. Until now, though, understanding of those diseases was...
Gladstone researchers resolve key Huntington's disease mystery in Nature cover story
...ington's and may add to the understanding of other neurodegenerative
disorders." Traditionally, scientists have tried t...bodies in Huntington's disease, and possibly other neurodegenerative
diseases, help neurons cope with toxic proteins and prevent neurodegeneration. The approach develope...
Study using robotic microscope shows how mutant Huntington's protein affects neurons
...e of Nature.* Inclusion bodies are common to many neurodegenerative
disorders, including HD, Parkinson's disease, Alzh...ce that inclusion bodies in HD, and possibly other neurodegenerative
diseases, help neurons cope with toxic proteins and avoid neurodegeneration. Many researchers have ...
Molecular mechanism sheds light on neurodegenerative diseases
...'s. Parkinson's. Lou Gehrig's. Huntington's. These neurodegenerative
diseases exhibit loss of nerve function in differe...h could lead to an understanding of how to prevent neurodegenerative
diseases and to the development of effective drugs, will be published Oct. 27 in The EMBO Journal, a...
Gene for common form of Parkinson's pinpointed
...roteins has been implicated in the pathogenesis of neurodegenerative
disease, it is particularly tempting to hypothesize a role for dardarin in the phosphorylation of proteins central to PD..." wrote the researchers. Coro Paisn-Ruz, Shushant Jain, E. Whitney Evans, William P. Gilks, Javier Simn, Marcel van der Brug, A...
Pesticides may promote Parkinson's disease and exercise may offer protection
...nts of this human illness. The second most common neurodegenerative
disease (after Alzheimer's disease), Parkinson's o...est for researchers studying Parkinson's and other neurodegenerative
diseases is programmed (or apoptotic) cell death, which is known to occur in these diseases. Przedbo...
Yerkes researchers to present array of new data at Society for Neuroscience Meeting
...interacts with other brain regions associated with neurodegenerative
diseases in order to determine the role of the PPT in neurodegeneration. (3 pm 5 pm)o determined vesicular glutamate transporters, a recently discovered group of proteins, regulate activity of the basal ganglia, a region of the brain that controls m...
Scientists raise concerns about second wave of 'mad cow' prion infection
...prevent human-to-human transmission of this fatal, neurodegenerative
prion disease at a symposium held last night at the annual AABB blood banking conference in Baltimore, Maryland. The symposium was sponsored by Pall Corporation (NYSE: PLL), the global leader in filtration technology. Citing two confirmed cases in t...
University of South Florida designated Center of Excellence by Huntington's Disease Society
... variety of basic science and clinical research on neurodegenerative
disorders, including Huntington's Disease. ... advance the understanding of other more prevalent neurodegenerative
diseases, Dr. Sanchez-Ramos said. "Parkinson's disease, Alzheimer's disease, amyotrophic lateral scl...
Columbia researchers identify drug as therapeutic candidate for spinal muscular atrophy
...ional developments and even a treatment for SMA, a neurodegenerative
disease that is the leading genetic killer of children younger than 2 in the United States and Western Europe. SMA has an incidence of 1 in 6,000 live births. Currently, no treatment exists. "Indoprofen is now both a chemical tool that researchers c...
Promising results in the battle against incurable ALS muscle disease
ALS is an incurable, paralyzing neurodegenerative
disorder that strikes 5 persons in every 100,000. The disease commonly affects healthy people in the most active period of their lives - without warning or previous family history. Researchers from VIB (the Flanders Interuniversity Institute for Biot...
New route to Parkinson's found in cells' 'garbage disposal' system
... into lethal clumps in neurons--a hallmark of many neurodegenerative
diseases. In the brain, the parkin protein works ...h, it may serve as a useful therapeutic target for neurodegenerative
diseases such as PD."...
Potent anticancer drug increases function of axons in mouse model of neurodegeneration
... cause a host of debilitating diseases. Since many neurodegenerative
diseases share or contribute to this pathology, th...confirm their potential as a new class of drug for neurodegenerative
disorders. "Now everyone is focused on drugs that disrupt the aggregated protein," says Trojanowski....
Blocking cell suicide switch fails to stop prion damage in mouse brains
...of effort being put into developing treatments for neurodegenerative
disorders that would inhibit neuron death. Our res...iseases, which are relatively rare, to more common neurodegenerative
disorders like Alzheimer's disease, where recent evidence has also elevated the importance of damage...
JCI table of contents, 3 January 2005
...aimed at validating the use of stem cells to treat neurodegenerative
disease" and this is most welcome particularly as investigators face yet another presidential moratorium endeavoring to limit the number of human stem cell lines that can be used for future research and treatment. TITLE: Dopaminergic neurons ...
Transplantation of monkey embryonic stem cells reverses Parkinson disease in primates
...aimed at validating the use of stem cells to treat neurodegenerative
disease" and this is most welcome particularly as investigators face yet another presidential moratorium endeavoring to limit the number of human stem cell lines that can be used for future research and treatment....
Mutations in transporter protein shed light on neurodegenerative disorders
...e new discoveries that shed light on two inherited neurodegenerative
disorders that are caused by inability of the body...diseases are a range of rare, autosomal recessive, neurodegenerative
disorders that result from the accumulation of sialic acid within lysosomes. There are two forms of ...
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