Researchers identify potential therapeutic target for Huntington's disease
...r treating Huntington's disease, a fatal inherited neurodegenerative disorder for which there is currently no effective treatment. The group, whose results appear in the May issue of Nature Genetics, includes researchers from the University of Washington School of Medicine in Seattle and the University of Maryland Sch......Microglia are critically involved, for example, in neurodegenerative diseases and stroke. So far, microglial cells have been studied in vitro, i.e. outside the living organism. As a result, key aspects of microglia function have remained elusive such as their behavior in the intact brain or their immediate response to...Scientists infuse rat spinal cords with brain-derived human stem cells
...od that may one day help surgeons treat the deadly neurodegenerative disease amyotrophic lateral sclerosis (ALS), resea...ngredient in the quest to cure spinal injuries and neurodegenerative disease. Rather, the scientists worked with more specialized neural stem cells -- known as neural pr...NIH awards Georgia Tech/Emory $11.5 M for nano cardiology research
...detection and treatment of other diseases, such as neurodegenerative and infectious diseases. "This program is only part of a larger scale biomedical nanotechnology effort at Georgia Tech and Emory," said Dr. Larry McIntire, The Wallace H. Coulter Chair in the Department of Biomedical Engineering at Georgia Tech and E...New insight into Huntington's disease pathology
...ations for understanding the pathogenesis of other neurodegenerative disorders, including other polyQ disorders, famili...ogenic mechanism warranting further studies in all neurodegenerative disorders," they wrote....Gene keeps neural cells on correct developmental path
...njuries or replacing malfunctioning brain cells in neurodegenerative diseases. It may also provide insights into other diseases, such as small cell lung cancer, which mistakenly make neuronal proteins, or neurological syndromes, where neuronal proteins produced by cancers may trigger the immune cells to attack the ner...HHMI awards first Gilliam Graduate Fellowships
...misfolded, can lead to congestive heart failure or neurodegenerative disorders. Naira Rezende, who earned a bachelor's degree in biology from Hunter College, is from Belo Horizonte, Brazil. She did summer research in HHMI investigator David Schatz's lab at Yale University School of Medicine, where she worked to inhi...Talalay receives Pauling Prize for Health Research
...rocesses of humans, such as heart disease, cancer, neurodegenerative disease and aging. The late Linus Pauling, the institute's founder, was a two-time Nobel laureate and OSU alumnus....First technology to remove prions that cause vCJD from blood launched
...y transfused blood component. Variant CJD, a fatal neurodegenerative disease, is the human form of Bovine Spongiform Encephalopathy (BSE), also known as Mad Cow Disease. The CE mark means the new prion reduction filter meets pan-European essential requirements for safety of medical devices. "The availability of our p...Applied NeuroSolutions biomarker may predict Alzheimer's disease progression
...heimer's disease patients from patients with other neurodegenerative disorders. Currently there is no FDA-approved diagnostic test for Alzheimer's disease. The market for an effective, easy to use, AD diagnostic test has been estimated to be approximately $5 billion. Applied NeuroSolutions, Inc. is developing produc...Unweaving amyloid fibers to solve prion puzzles
...as the plaque that gunks up neurons in people with neurodegenerative illnesses such as Alzheimer's and Creutzfeldt-Jacob disease--the human analog of mad cow disease. But even though amyloids are common and implicated in a host of conditions, researchers haven't been able to identify their precise molecular structures...Deadly infectious entity of prions discovered
...also may help to improve our understanding of such neurodegenerative diseases as Alzheimer's, in which brain cells gradually "silt up" with structures similar to the prion beta-sheet that are connected to brain cell death....Tetanus toxin found to have therapeutic properties
... anxiety and anorexia, and to slow the progress of neurodegenerative disorders such as Parkinson's disease. Tetanus tox...effective than neurotrophins as protection against neurodegenerative disorders such as Parkinson's disease....Pioneering research on ALS muscle disease rewarded
...Lateral Sclerosis (ALS) is an incurable paralyzing neurodegenerative disorder that strikes five out of every 100,000 persons. The disease usually affects healthy people in the most active period of their lives - without warning or previous family history. Researchers from VIB (the Flanders Interuniversity Institute fo...Purdue scientists may have found key to halting spinal cord damage
... could also improve treatments for a host of other neurodegenerative conditions. A research team led by Riyi Shi (REE-y... concentration of acrolein also has been linked to neurodegenerative conditions such as Parkinson's, Huntington's and Alzheimer's diseases - all of which progress slowly...Researchers discover stem cell 'guide' that may be key for targeting neural stem cell treatments
... specificallytargeted to brain regions affected by neurodegenerative diseases or bystroke. Associate Professor Qun-Yong Zhou and graduate student Kwan L. Ng in theUCI Department of Pharmacology have identified a protein that guidesthese new neurons to a particular brain region. The protein, a smallpeptide called proki...Nerve protector could make for new stroke treatments
...f nerve cell injury and death associated with many neurodegenerative diseases and stroke. The study, led by Stuart Lipton, MD, PhD, professor and director of Burnham's Del E. Webb Center for Neuroscience and Aging Research, is published in the July issue of the Journal of Neuroscience. There is but one medical treat...42 biomedical scientists worldwide named HHMI international research scholars
...rotein particles that are thought to cause certain neurodegenerative diseases, such as so-called mad cow disease. She will work with a group to establish systematic human prion disease screening in Brazil. * Geoff McFadden Professor School of Botany University of Melbourne Melbourne, Aus...Discovery could lead to new types of Alzheimer's drugs
...may lead to the cellular destruction seen in these neurodegenerative diseases. "These ion channels could serve as a model system for designing preventive and therapeutic drugs," said Lal. "You don't need large aggregates of these amyloid proteins, the plaque, to have this disruption. Rather, small aggregates, when in ...Huntington's cure in flies lays groundwork for broader treatment approaches
... Laboratory have cured fruit flies of the genetic, neurodegenerative condition. Forms of the same proteins-known in short form as CREB and HSP-70--exist in all cells, including those of humans. The study results, published online today by the Proceedings of the National Academy of Sciences, were a "logical finding" be...