Tag: "neurodegenerative" at biology news

Biotechnology Study Center honors Jean-Pierre Changeux, Charles Weissmann and Eric Kandel

...C. He has also unraveled the molecular genetics of neurodegenerative diseases (scrapie, Creutzfeldt-Jacob or "mad cow" disease) caused by infective protein particles, prions, and developed tools for the detection and decontamination of prions in veterinary and clinical settings. The NYU Alumnus Achievement Award: Er...

March of Dimes awards $250,000 prize to research pioneer

...ons for research into the causes of birth defects, neurodegenerative syndromes, cancer, and immune disorders. "Dr. Varshavsky's work has provided rich insight into the ubiquitin system and its crucial role in regulating living cells," said Dr. Jennifer L. Howse, president of the March of Dimes. Dr. Varshavsky was bo...

Study finds a high caloric diet may prevent the progression of amyotrophic lateral sclerosis

...ll death, the cause of ALS. ALS is an adult-onset neurodegenerative disorder in which spinal and cortical motor neurons die causing relentlessly progressive weakness and wasting of skeletal muscles through the body. "ALS is such a devastating disease for those individuals diagnosed with the disorder," said Giulio Ma...

Discoveries should aid research into cause of ALS

...ty have found a novel pathological hallmark of the neurodegenerative disease amyotrophic lateral sclerosis (ALS) at the...it so toxic that it kills motor neurons and causes neurodegenerative disease? The presence of aggregated proteins is common to many neurodegenerative disorders, includi...

Mutant mice show key autism traits

...suggests that ASD is a developmental rather than a neurodegenerative disorder." Greer and Wynshaw-Boris concluded that "Whether or not the findings . . . have direct relevance to ASD, the experimental results described are intriguing and represent an important entry point to understanding the role of Pten in postmitot...

Research shows how visual stimulation turns up genes to shape the brain

... These findings suggest that genetic therapies for neurodegenerative diseases, some of which are largely limited to treatment focused on a single gene, will require more extensive knowledge of molecular pathways and gene interactions to be successful Majdan and co-author Carla Shatz, HMS Nathan Marsh Pusey Professor o...

'Smart' genetic therapy helps the body to heal itself

... of the ALD protein and prevent the development of neurodegenerative symptoms. This striking prevention of the disease lasted during the whole 2 year life span of the mouse. "Knowing that a class of drug called histone deacetilase (HDAC) inhibitors was able to stimulate the expression of ALDR in the mouse and in huma...

Gladstone scientists prove neurons produce Alzheimer's-linked apolipoprotein E

...unraveling the mechanisms underlying apoE4-related neurodegenerative disorders." "ApoE expression can be detected with unprecedented sensitivity and resolution in these mice," explains Qin Xu, PhD, a Gladstone postdoctoral scholar and first author of the paper. "This mouse model, known as the 'EGFP knock-in,' is a new...

Prozac's target revealed

... eventually lead to cell replacement therapies for neurodegenerative and other brain disorders including Alzheimer's and Parkinson's disease. It has been known for some years that Prozac (fluoxetine) is likely to relieve the symptoms of depression by somehow causing more neurons to be present in a particular region of...

Heal thyself: Systems biology model reveals how cells avoid becoming cancerous

...at a broad spectrum of diseases, including cancer, neurodegenerative diseases, and premature aging." Researchers involv...is disabled, ataxia telangiectasia, a progressive, neurodegenerative childhood disease, Werner syndrome, a premature aging disorder, and others. "DNA damage is a basic ...

Key stress protein linked to toxicities responsible for Parkinson's, Alzheimer's

...oteins that lead to nerve cell injury and death in neurodegenerative disorders such as Alzheimer's and Parkinson's Dise...ommon pathway in the pathogenesis of virtually all neurodegenerative conditions. Such conditions also include ALS (or Lou Gehrig's disease), Huntington's disease, and m...

Research suggests cause of neurodegeneration in Huntington's disease

... prevent this kind of defect." Research into other neurodegenerative disorders may also benefit from a thorough understanding of HAP1. "This work also has implications for understanding the normal physiological processing for neuronal functioning," says Dr. Li....

Proteins linked to cancer prevention in humans affect aging in worms

...eurons could provide a new avenue of treatment for neurodegenerative diseases."...

Worm links cancer risk to ageing

...urons' could provide a new avenue of treatment for neurodegenerative diseases like Alzheimer's."...

Unraveling Alzheimer's: Clues may be found visualizing plaques in human brain, mad cowtype diseases

...we were able to visualize abnormal protein in both neurodegenerative diseases--Alzheimer's and scrapie--and this could ...disease. Prions cause a number of rare progressive neurodegenerative disorders that affect both humans and animals, and the diseases are usually rapidly progressive and ...

Protein's role in regulating cell death sets direction for cancer research

...ght seem like a bad thing that could contribute to neurodegenerative disease," says Dr. Greer who produced the study with Yinfei Tan, Nathalie Dourdin, Chao Wu, Teresa De Veyra, and John S. Elce. "On the other hand, when a cell's chromosomes are damaged by carcinogens or ultraviolet light in a way that could initiate ...

Seeing beyond the gray areas: New tool uncovers the importance of the brain's white matter

...white matter connections in psychiatric disorders, neurodegenerative disease and neuromuscular disorders. This new information on the role of white matter in the brain's functioning may also manifest ethical issues on how it should be used....

Gene therapy injected into the brains' of mice with Huntington's disease

... carriers destined to suffer from HD. Unlike other neurodegenerative disorders, identification of the genetic markers p...led CERE-120) as a potential treatment for several neurodegenerative diseases, while using AAV-GDNF for 'proof of principle' research studies. The mice in this study wer...

Gene mutation may influence age at onset of Parkinson's disease

...ing to background information in the article. The neurodegenerative disorder is characterized by tremors, rigid movements, difficulty walking and a mask-like facial appearance. Though much about the development of Parkinson's disease remains unknown, family history has been found to significantly increase risk. Res...

Single copy of Parkinson's-risk gene mutation may lead to earlier symptom onset

...led by Richard Myers, PhD. Parkinson disease is a neurodegenerative disorder characterized by tremors, rigidity, diffi...transmitter dopamine and is the second most common neurodegenerative disorder. The condition's prevalence increases with age appearing in 1 percent of those over 60 and...

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