Tag: "neurodegenerative" at biology news
Salk and Stanford teams join forces to reveal two paths of neurodegeneration
...is was that "the axon degeneration at the heart of neurodegenerative
diseases may be a misuse of normal pruning programs, but our studies suggest that two different mechanisms are involved." According to Luo, these findings also suggest strategies to slow neurodegeneration. "Wlds protein protects axons after injury a...
Rare disease's gene may illuminate major disorders
...n's diseases. "This is a common end effect of many neurodegenerative
disorders," Hayflick said....
Neurons grown from embryonic stem cells restore function in paralyzed rats
... cells can protect at-risk neurons, but in ongoing neurodegenerative
diseases, there is a very small window of time to do so. After that, there is nothing left to protect," says Dr. Kerr. "To overcome the loss of function, we need to actually replace lost neurons." While these results are promising, much work remains ...
The protein that makes you mad
...are proteins without DNA capable of causing rare neurodegenerative
diseases, currently without a cure, by means of a novel process different from that of the "classic" virus and bacteria. The prion presents two distinct forms: a "healthy" one present in all animals (PrP c ) and another, pathogenic one (PrP sc ), whi...
Researchers reverse Parkinson's symptoms in animal models
... organisms to study something as deeply complex as neurodegenerative
disease," says Lindquist, who is also a professor of biology at MIT. "Most people thought we were crazy. But we now not only have made progress in understanding this dreadful disease, but we have new platform for screening pharmaceuticals." These fi...
Parkinson's disease mechanism discovered
...derlying causes of Parkinson's disease and related neurodegenerative
disorders. The research team, which included Howard Hughes Medical Institute investigators Susan L. Lindquist and Nancy M. Bonini, published their findings on June 22, 2006, in Science Express, which provides electronic publication of selected Scienc...
Tips from The Journal of Neuroscience
...-associated protein tau is associated with several neurodegenerative
diseases, and in the case of FTDP-17 (frontotemporal dementia with parkinsonism-linked to chromosome 17), tau mutations are sufficient to produce neurodegeneration. This week, Dickey et al. focused on the role of the cochaperone and ubiquitin ligase ...
A probable cause for Parkinson's?
...found nitration of proteins that are implicated in neurodegenerative
disease," said Colette Sacksteder, PNNL scientist ...n the mouse brain. The research suggests that many neurodegenerative
diseases leave a biochemical calling card, or biomarker, that could be used to predict the earliest ...
Dopamine drug leads to new neurons and recovery of function in rat model of Parkinson's
...ings may lead to new ways of treating PD and other neurodegenerative
diseases. The study was funded in part by the NIH...uroscience.* Parkinson's disease, a progressive neurodegenerative
disorder that causes tremors, stiffness, slow movements, and impaired balance and coordination, resu...
Cause of neuronal death in Down's syndrome, Alzheimer's disease could be surprisingly simple
...in Down's syndrome, Alzheimer's disease, and other neurodegenerative
disorders. The researchers said their basic findin...he trisomic mouse model] may be directly linked to neurodegenerative
diseases." Tessarollo and colleagues also noted that "Alterations in neurotrophins or their Trk r...
Mapping the protein world
...t play crucial roles in cancer, cardiovascular and neurodegenerative
diseases and molecules from pathogenic bacteria or viruses will contribute to design new revolutionary therapeutic strategies." To meet this objective the scientists intend to study crystals of proteins bound to diverse drug candidates or containing...
Researchers uncover genetic clues to a common form of age-related dementia
...ntribute to the development of a relatively common neurodegenerative
disease known as dementia with Lewy bodies, or DLB...75 patients who had been diagnosed with a class of neurodegenerative
disorders known as synucleinopathies, which are characterized by abnormal aggregates of a protein ca...
NC State scientists characterize protein linked to neurodegenerative diseases
...e formation, which are hallmark characteristics of neurodegenerative
disease. Until now, however, the structure of calbindin-D28K remained a mystery. "If you don't know the shape of the protein, you can't figure out how it works," Cavanagh says. "It took a long time about five years but we've characterized the str...
JCI table of contents: July 27, 2006
...nstead of trying to deliver therapeutic agents for neurodegenerative
diseases across the highly impermeable blood-brain...in the central nervous system (CNS) underlies many neurodegenerative
diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and ALS. Several st...
New discovery about Parkinson's at the Montreal Neurological Institute
...er at the MNI, studies Parkinson's disease (PD), a neurodegenerative
disease that causes muscle stiffness and tremor an...gnaling pathway--has recently been linked to other neurodegenerative
diseases in addition to PD. This new-found interaction between Akt and parkin suggests that PD and o...
New research points toward mechanism of age-onset toxicity of Alzheimer's protein
LA JOLLA, CA - Like most neurodegenerative
diseases, Alzheimer's disease usually appears late...ce. "Aging is the most important risk factor for neurodegenerative
diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease," says senior au...
Scientists discover age-regulated cellular activities that protect against protein aggregation
... single drug-that would be useful for a variety of neurodegenerative
diseases where protein aggregation leads to neurodegeneration." In addition to Kelly and Bieschke at Scripps Research and Dillin and Cohen at Salk, Technician Rhonda Perciavalle of the Salk Institute also made significant contributions to the Scien...
New biomarkers could help doctors spot Alzheimer's and other neurodegenerative diseases
...at can indicate whether a patient has a particular neurodegenerative
disease, or determine the progression of a disease...erebrospinal fluid from patients with one of three neurodegenerative
diseases: Alzheimer's, Parksinson's, or dementia with Lewy bodies (DLB). Researchers identified diff...
'Sticky' mice lead to discovery of new cause of neurodegenerative disease
...ayward gene. Now scientists are learning that some neurodegenerative
diseases can develop even though a gene is perfect...lates in neurons. Researchers have long known that neurodegenerative
disorders can be caused by the gradual yet persistent accumulation of misfolded proteins in neurons ...
NIH funds 14 High-End Instrumentation grants
...) mass spectrometer will enable research involving neurodegenerative
diseases, respiratory illnesses, and cancer. ...nance imaging (MRI) system will assist in studying neurodegenerative
and metabolic disorders, detecting cancer and monitoring treatment, and developing novel approaches ...
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