Gilbert Foundation and American Fed for Aging Research award grants on Alzheimer's disease
...aperones help in the processing of proteins within neurons and may represent an entirely novel class of candidates for therapeutic development in Alzheimers research. Isabella A. Graef, M.D., Assistant Professor, Stanford University: "Harnessing endogenous proteins to prevent and clear pathogenic protein...News tips from the Journal of Neuroscience
...orylated active) Pak1 peaked at the same time that neurons became polarized with distinct axons and dendrites... morphological development of dendrites and axons; neurons did not survive past 7 DIV when Pak1 expression was silenced by RNA interference. 3. Toward an...UCLA scientists produce functioning neurons from human embryonic stem cells
...cells a highly pure, large quantity of functioning neurons that will allow them to create models of and study... Researchers previously had been able to produce neurons - the impulse-conducting cells in the brain and spinal cord - from human embryonic stem cells. Howev...UCF research links proteins, stem cells and potential Alzheimer's treatment
...ase. The combination triggered the regeneration of neurons that are destroyed by Alzheimers and are necessary...planted into aged rats seemed to become functional neurons and improved age-associated memory loss, with no side effects. When Sugaya transplanted stem cells...Not all embryonic stem cell lines are created equal
...yonic stem (ES) cell lines are equal. In comparing neurons generated from two NIH-approved embryonic stem cel...significant differences in the mature, functioning neurons generated from each line. The discovery implies that culture conditions during ES cell generation --...JCI table of contents: August 1, 2007
...these processes. Expression of the protein AMPK in neurons in the brain has been suggested to be important for regulating energy balance, but in which neurons its expression is important was not clear. To address this issue, Dominic Withers and colleagues f...New study demonstrates important role of glia in circadian timing
...lia are located in close proximity to dopaminergic neurons in the brains of Drosophila. We propose that glia ...cadian activity rhythms. Glia may communicate with neurons of the circadian system and help to coordinate their outputs, which are critical for the temporal co...Fish eyes could hold clue to repairing damaged retinas in humans
...o develop the cells in vitro into all the types of neurons found in the retina. When tested in rat models with diseased retinas, the cells migrated into the retina and took on the characteristics of the surrounding neurons. The researchers are now looking at developing this approach for use in the human e...Huntington's disease study shows animal models on target
...rked resemblance between the molecular etiology of neurons in animal models and neurons in patients with HD. This implies that animal models are relevant for studying human HD and testing ...Stem cell therapy rescues motor neurons in ALS model
...dison has shown it is possible to rescue the dying neurons characteristic of amyotrophic lateral sclerosis (A... secrete a key growth factor can protect the motor neurons that waste away as a result of ALS. An important caveat, however, is that while the motor neurons wi...News tips from the Journal of Neuroscience
...nsic membrane excitability of tadpole optic tectal neurons during the period from early synapse formation (st...son Although similar in many ways, dopaminergic neurons of the substantia nigra (SN, A9) and the ventral tegmental area (VTA, A10) differ in their vulnerabi...JCI table of contents -- July 26, 2007
...ptor 1 (SUR1) was increased in the capillaries and neurons surrounding the lesion and also associated with expression of SUR1-regulated, calcium-activated cation channels known as NC[Ca-ATP] channels. The authors went on to show that suppression or blockade of SUR1 activity following spinal cord injury essen...News tips from the Journal of Neuroscience
...ransgenic mice did not. Similarly, ATF3-expressing neurons were unable to overcome myelin inhibition. Thus AT...After theta-burst stimulation (TBS), CA1 pyramidal neurons generated new dendritic spines that lasted throughout a 19 h imaging period. Spines were visualized ...Steroids, not songs, spur growth of brain regions in sparrows
... growth-inducing proteins whose synthesis by brain neurons is stimulated by testosterone. In sparrows, brain areas are directly stimulated by these hormones to grow and one day such hormones might possibly help repair brain damage caused by strokes or neurodegenerative diseases, said Brenowitz....Neurons for numerosity: Parietal neurons 'sum up' individual items in a group
...ical behavior, the authors studied the activity of neurons in the lateral intraparietal area in monkeys while...d at arrays of dots on a computer screen. Parietal neurons responded with progressively increasing activity as the total number of elements in the display was ...'Preconditioning' helps protect brain's blood vessels from stroke
...ay. And we know it can help protect brain cells -- neurons -- against stroke damage," Dr. Iadecola says. "Now, besides illuminating mechanisms involved in this process, our new study in mice demonstrates that preconditioning also shields the brain's blood vessels from stroke injury," he explains. "The hop...New clue into how diet and exercise enhance longevity
...e. Because reducing insulin-like signaling in the neurons of roundworms and fruitflies extends their lifespan, the researchers decided to examine what would happen when they knocked out one or both copies of the Irs2 gene only in the brains of mice. Mice lacking one copy of the Irs2 gene in brain cells...Scientists a step closer to understanding how anaesthetics work in the brain
...The study focuses on a particular protein found in neurons in the brain, known as a potassium channel, which ... the neuron. Communication between the millions of neurons in the brain which is the basis of human consciousness and perception, including perception of pain...UCLA researchers show that culture influences brain cells
...ure on the so-called mirror neuron network. Mirror neurons fire when an individual performs an action, but th...mmunal but local traditions, said Iacoboni. Mirror neurons are the brain cells that help us in shaping our own culture. However, the neural mechanisms of mirro......female reproductive cycle are events controlled by neurons in the hypothalamus that secrete gonadotropin-releasing hormone (GnRH). How signaling to these neurons is controlled remains unclear. In a study appearing online on July 12 in advance of publication in t...