Using fruitflies to examine alcohol tolerance
...a neuromodulator that serves as the fly version of norepinephrine showed reduced rapid tolerance but unchanged chronic tolerance. In sum, two different lines of experiments provide pharmacological and genetic support for the idea that rapid and chronic tolerance may utilize at least partially distinct pathways ...Stress impairs thinking via mania-linked enzyme
...ress. When the stress-sensitive messenger chemical norepinephrine binds to receptors on cell membranes in the prefrontal cortex, it activates PKC through a cascade of events. The enzyme then travels out to the cell membrane, opening ion channels that heighten the cell's excitability, and stoking protein machinery t...Epilepsy and depression - A two-way street?
.... The abnormal secretion patterns of serotonin and norepinephrine in these animals are similar to abnormal patterns for the same neurotransmitters seen in patients with depression, Kanner said. He summarized the evidence for common biological pathways in a paper published in January in the journal Epilepsy Currents...Amphetamine-related drugs ameliorate symptoms of Parkinson's
...neurotransmitters such as dopamine, serotonin, and norepinephrine and cause sudden bursts in neurotransmission, lead...eating the mice with drugs related to serotonin or norepinephrine did not ameliorate the disease's symptoms. These results suggest that MDMA likely acts through a pat...Univ. of Chicago scientists find potential cause of breathing problems in Rett Syndrome children
...odulator norepinephrine. When Ramirez's team added norepinephrine to the isolated breathing center, the breathing pa...t the behavioral level. However, the deficiency in norepinephrine eventually disturbs other neuromodulators, including serotonin and substance P. As other modulatory ...Increasing norepinephrine stabilizes breathing patterns in a mouse model of Rett Syndrome
... originate, at least in part, from a deficiency in norepinephrine and serotonin in a specific brain region called th...T exhibits typical breathing and normal content of norepinephrine in the medulla. The medulla is a section of the brainstem that is responsible for autonomic function...Undergraduate researcher turns up the heat on hibernation
... mice that cannot synthesize the neurotransmitters norepinephrine or epinephrine do not enter torpor when they fast. In 2004, Smith joined Swoap's research team as an HHMI summer research fellow. Williams College, like more than 100 colleges and universities throughout the United States, has an undergraduate scie...Alcoholism, smoking and genetics among Plains American Indians
...an important role in the breakdown of dopamine and norepinephrine in the brain, its activity varying according to a ...nt enzyme and therefore probably more dopamine and norepinephrine in the brain," she said. "The Met allele has also been associated with increased anxiety and neurot...Ritalin packs punch by elevating norepinephrine, suppressing nerve signal transmissions
...(May 30, 2006) Methylphenidate (Ritalin) elevates norepinephrine levels in the brains of rats to help focus attenti...ing rats, is the first to document the increase in norepinephrine and suppression of the neuronal response in this sensory pathway of the brain. "Methylphenidate enha...Bacteria, beware: New finding about E coli could block infections, lead to better treatments
...obial flora and the human hormones epinephrine and norepinephrine alert the bacteria to its location. This cellular ...or would use to recognize the host epinephrine and norepinephrine signals thus blocking the QseC receptor from sensing the signals and preventing it from being able ...News tips from the Journal of Neuroscience
...sought to link the established cellular actions of norepinephrine to LC function. In a technical tour de force, the ...g rats. Microstimulation of the LC output enhanced norepinephrine influx in VPM and modulated the responses of individual units (neurons) to whiskerpad stimulation. A...Effectiveness of certain antidepressants may be influenced by gene variations of individuals
...e significant associations between the efficacy of norepinephrine reuptake inhibitors (NRIs - a class of antidepressant drugs) and norepinephrine transporter (NET) polymorphisms and also between SSRI efficacy and 5-HTT polymorphisms. If confirmed...Research links 'ecstasy' to survival of key movement-related cells in brain
...s of the neurotransmitters serotonin, dopamine and norepinephrine in the brain. This secretion can lead to prolonged periods of activity, hallucinations and euphoria. Before the United States banned it in 1985, MDMA was tested as a possible adjunct in psychotherapy. In 2001, the FDA agreed to allow MDMA to be teste...Orexigen reports positive phase II results for Excalia Combination-Therapy to treat obesity
...oprietary combination of bupropion, a dopamine and norepinephrine reuptake inhibitor, plus zonisamide, an approved anticonvulsant medication. OREXIGEN's preclinical research suggests that combining these two central nervous system drugs acts on a complex of neurons in the hypothalamus, the area of the brain contrib...Molecule discovered to be key to pain sensitivity
...sential for the production of serotonin, dopamine, norepinephrine and nitric oxide. Tests in rat models found that the BH4-synthesizing enzymes were activated in injured sensory neurons and that substances known to inhibit those enzymes reduced pain, acting as analgesics. Directly injecting BH4 or a similar molec...Stress hormones may play new role in speeding up cancer growth
... was that the two stress hormones epinephrine and norepinephrine would bind to places on the surface of ovarian ca...se descent. They treated Glaser's cell line with norepinephrine and, as predicted, the cells all produced MMP-2, MMP-9 and VEGF. This showed that the receptors for ...Genetic mechanism helps explain chronic pain disorders
...metabolizes neurotransmitters such as epinephrine, norepinephrine and dopamine and that has been implicated in the modulation of persistent pain, as well as cognition and mood, is regulated by a gene, also called COMT. Previous UNC-led research showed that common genetic variants of this gene are associated with in...Brain networks strengthened by closing ion channels
...Treatments for ADHD all enhance stimulation of the norepinephrine receptors. These new data also have important implications for the researchers studies of more severe mental illnesses like schizophrenia and bipolar disorder, which can involve mutations of a molecule called DISC1 (Disrupted in Schizophrenia) that n...Pediatric ritalin use may affect developing brain, new study suggests
...ions in brain chemicals such as catecholamines and norepinephrine in the rats' prefrontal cortex -- a part of the mammalian brain responsible for higher executive thinking and decision-making. There were also significant changes in catecholamine function in the hippocampus, a center for memory and learning." Trea...