Identified mechanism in the malaria parasite to help it adapt to infected individuals
...ithout compromising the parasites ability to enter normal or modified red blood cells. According to Corts, this suggests that the varied expression of these genes may help the parasite to escape the host organisms immune responses, although the researcher points out that this is yet to be confirmed. The r...Unknotting DNA clue to cancer syndrome
.... Such rearrangements can lead to cancer. In their normal forms, the SGS1 and Bloom's proteins keep the situation under control by separating the entangled chromosomes and preventing undesirable crossovers. While these experiments were done in yeast, Hunter predicted that the results could be extended to ...Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer
...cular human common fragile site an area that is a normal part of chromosome structure but is prone to breaking. The site lies in the middle of a tumor suppressor gene and chromosome breakage in this area is highly associated with cancer. "It is an area that has a tumor suppressor gene a gene whose absen...A low expression of MX2 gene exists in the white blood cells of narcoleptics
...antly less expressed in narcoleptics compared with normal subjects. This underlies the abnormalities in the blood cells of persons suffering from narcolepsy, according to a study published in the August 1st issue of the journal SLEEP. Susumu Tanaka, PhD, of the Tokyo Institute of Psychiatry in Japan, con...Altering a protein makes mice less fearful
...of open spaces, loud noises and predator odor than normal mice. In the odor test, the researchers placed a...d that chemically inhibiting the ASIC1a protein in normal mice (using a component of tarantula venom) similarly blunted the innate fear response. "Showing t...COX-2 inhibitors delay pancreatic cancer precursors in mice
...reatic ducts had PanIN-2 or -3 in KrasG12D mice on normal diet). Because the pancreases of mice were analyzed at 10 months, before the typical appearance of pancreatic tumors, additional studies will be needed for researchers to conclude whether or not nimesulide can delay the onset of or prevent pancreat...Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer
...ne of cancer cells. The protein is rarely found in normal tissues, but is produced at high levels by a wide ...igrate to tumors and kill them without harming any normal tissues. In essence, its like turning up your stereo in the hopes that it will attract the poli...... would knock out the anthrax microbe but leave the normal good bacteria in the gut alone. As a first step, U-M scientists plan to screen compounds to find ones able to block specific processes they have identified in the anthrax microbe....Handicapping tuberculosis may be the way to a better vaccine
...activity. When they compared this mutant strain to normal TB, they saw that it did in fact cause increased a...cytes recognize the same peptide. They altered the normal and the apoptosis-inducing strains of TB to produce this peptide. The researchers transferred thous...JCI table of contents: August 1, 2007
...d had a shorter lifespan than red blood cells from normal mice. Importantly, treatment of the cells with an antioxidant increased the lifespan of the red blood cells lacking Foxo3. A lack of Foxo3, and therefore high levels of oxidants, also decreased the rate of red blood cell development and led the autho...New study demonstrates important role of glia in circadian timing
...udies have suggested that glia may be required for normal circadian behavior, specific glial factors that are needed for this process had not been identified. Jackson and his colleague Joowon Suh, a student in the Sackler School of Graduate Biomedical Sciences neuroscience program at Tufts, used cellular...Forsyth scientists gain new understanding of adult stem cell regulation
...ation are a critical component for development and normal physiology....Aggressive therapy best for certain AML patients
...ften relapsing within a year. Of AML patients with normal chromosomes who lack the mutation, on the other hand, four in 10 are cured. The new study suggests that treating patients who have the mutation with an aggressive therapy such as an autologous stem cell transplant while they are in remission might...Molecule blocks gene, sheds light on liver cancer
... measuring the relative levels of 197 microRNAs in normal liver cells and in liver cancer cells from human t... times greater in liver-tumor tissue compared with normal liver tissue, twice that of the next highest microRNA. Earlier research led by Patel had shown th...First case of successful ovarian tissue transplantation between two, nonidentical sisters
...os ceased to develop, but this also happens during normal cycles of IVF. The patient is planning more IVF attempts in the future. He said that it was too early to say whether this procedure would ever be successful enough to enable a woman to become pregnant successfully and give birth to a live baby. How...Fish eyes could hold clue to repairing damaged retinas in humans
... is possible that internal mechanisms exist in the normal adult retina that prevent these cells from dividing and replicating. "Our next step is to identify which factor is responsible for blocking the regeneration," says Dr Limb. "Once we know how this mechanism works, we will be much closer to develop...MGH researchers confirm that bone marrow restores fertility in female mice
...on to have successful pregnancies throughout their normal reproductive life. The report in the August 1 Jou...ertility-destroying doses of chemotherapy appeared normal and contained immature oocytes expressing a marker protein indicating they came from the donor cells...New studies on goats' milk show it is more beneficial to health than cows' milk
... properties of goats milk and cows milk, both with normal calcium content and calcium enriched, against the ...o points out that the inclusion of goats milk with normal or double calcium content in the diet favours digestive and metabolic utilisation of iron, calcium a...Negative effects of plastic's additive blocked by nutrient supplements
...A comparison between the large yellow mice and the normal brown mice showed identical genetic makeup, yet strikingly different appearances. Just as importantly, when pregnant mothers were also given folic acid or genistein, the epigenetic influence of BPA was counteracted, she added. BPA is a synthetic ......ly to control its troublesome tendency to suppress normal breathing. This proposal provides an approach to achieve sustained, safe pain control on the battlefield, says the U-M research teams leader, James R. Baker, Jr., M.D., director of the Michigan Nanotechnology Institute for Medicine and Biological ...