Molecular detectors may refine cancer treatment
...dhered to all types of cancerous cells but ignored normal blood and bone marrow cells. In combination, the six aptamers produced distinct patterns that characterize different cancer cells, suggesting that the technique could be useful to detect the molecular fingerprints of cancer in people. The next step...New role for protein in fat cells may improve understanding of obesity and diabetes
...yl ester, and another fat called triglyceride like normal fat cells do. In CETP-deficient cells, cholesteryl... in fat cells. Morton and Izem suggest that, in normal cells, CETP transfers cholesteryl ester and triglyceride from the ER, where they are made, to the li...JCI table of contents: July 19, 2007
...erized by insulin resistance a condition in which normal amounts of insulin are not adequate to produce a normal insulin response from fat, muscle, and liver cells. The result is an elevation in blood glucose leve...Restless legs genetics on the move
...n 400 RLS patients and 1600 test subjects from the normal population was measured. This genome-wide comparison of frequent variants also referred to as genome-wide association study is one of the highlights of genome research this year. Groups of scientists from Germany, Austria and Canada were involved. ...New proteomics research promises to revolutionize biomedical discovery
...nts the fingerprint of the physiological status of normal human cells and the signature of some disease conditions. If this comprehensive repertoire of protein interaction networks, termed the Human Proteotheque, can assist scientists worldwide in identifying important new proteins that can be used to diagn...Ability to listen to 2 things at once is largely inherited, says twin study
...isorders (APDs)in which individuals with otherwise normal hearing ability have trouble making sense of the s...fraternal and a hearing test to make sure they had normal hearing. If a trait is purely genetic, identical twins, who share the same DNA, will be alike near...Better sleep may put Huntington's disease sufferers back on track
... the first time that treatments aimed at restoring normal sleep-wake activity could slow the cognitive decline that is such a devastating feature of the disease. Dr. Jenny Morton, lead author of the study, said: In the future, more attention should be paid to understanding sleep and circadian disturbance ...Losing weight after pregnancy -- diet and exercise better than diet alone
...e and dieting did lose more weight than those with normal care. Returning to body weight gradually after giving birth seems to be important, because women who regain their pre-pregnancy weight within six months have a lower risk of being overweight ten years later. As well as helping reduce body weight,...Scientists take next step in understanding potential target for ovarian cancer treatment
... Ph.D., professor of pharmacology, is studying the normal function of a protein called km23, the traffice co...an cancer. No similar alterations were found in normal human tissues, suggesting that the km23 alterations may be a possible diagnostic indicator for devel...Tumor painting revolutionizes fight against cancer
...help surgeons distinguish between cancer cells and normal brain tissue in the operating room. The paint is a...er in diameter without lighting up the surrounding normal brain tissue. In a prostate cancer model, as few as 200 cancer cells traveling in a mouse lymph cha...Serica scientists win AOSSM Award for ACL (knee) tissue regeneration in preclinical study
...aring at 3, 6 and 12 months, with 95% returning to normal gait by 6 months; the majority of knees were clini...motion assessment indicated the knees maintained a normal range flexion and extension at all points. By 12 months, the initial SeriACL graft structure was no...HWI researchers determine structure of protein from pathogen associated with CF and TB
...tructure of a protein that is essential to produce normal amounts of one of these complex molecules in Pseudomonas. What is interesting is that other bacteria use a very similar protein and we assume the proteins will be essential there as well. This work gives us clues to the role of this protein and we ...Small molecules may explain psoriasis
... patterns of expression in psoriasis compared with normal skin and also in comparison with atopic eczema. One of these molecules, miR-203, is of particular interest as it is greatly upregulated in psoriasis and is only expressed by the skins epithelial cells, keratinocytes. No one has previously investig...Antibody retards growth and induces death in liver cancer cells
...t and human liver cancer cell lines as compared to normal cells in culture. Dr. Mongas group then treated...apoptosis, among the cancer cell lines compared to normal control cells. According to Dr. Monga, these results suggest that PDGFR offers an important new th...New use for a cell toxin found to inhibit survival proteins in cancer cells
... to chemotherapy and radiation therapy. Cells with normal levels of Bcl-2 or Bcl-xL are resistant to 2-Metho... high expression of the proteins versus cells with normal expression, said Hockenbery, who is also a professor of medicine at the University of Washington Med......rs found that Ago2 is, indeed, quite necessary for normal blood cell development. Its endonulcease activity, however, is not. The scientists were able to restore erythropoiesis in Ago2-deficient mice by expressing a mutated version of Ago2 that lacks its endonuclease activity, thereby demonstrating that t...Mild stress in the womb may worsen risk of cerebral palsy
...earch. In the study, the scientists adjusted the normal cycle of light and dark that the pregnant mice were accustomed to for half of the mice, subjecting them to a mild level of stress. Then the researchers exposed the brains of the developing fetuses to injury. When the brains of the young mice were exa...Insulin sensitizer also serves as energy-conserving signal to the brain
...ectin lost more fat after 12 hours of fasting than normal mice did. Blood levels of another fat hormone, leptin, are regulated inversely in relation to serum adiponectin levels, the researchers noted. Thus, central adiponectin/leptin signals may represent the physiological pathway by which hypothalamic ...New blood test might offer early warning of deep belly fat
... triple the concentrations found in individuals of normal weight. We believe that in the near future, mea... impaired glucose tolerance, and even in otherwise normal people with a strong family history of diabetes. Likewise, interventions designed to improve insulin...New research shows vaginal bacteria vary among healthy women, need customized treatment
...f Idaho is helping to increase understanding about normal vaginal biology so that physicians can better iden... from the study: there are at least eight kinds of normal vaginal bacterial communities, each community is different, and, among the eight kinds of communitie...