Biodesign Institute leads innovative project to prevent cancer
...her tumors, the research team will use patient and normal samples from extensive tissue banks at the Mayo Cl...n immune response against breast tumors but not in normal cells, said Johnston. Johnston knows demonstrating their approach will be a significant challenge...'Virtual' mouse brains now available online
...one video two different mouse brains -- one from a normal animal and the other from a rodent missing a gene linked to mental abnormalities -- seem to assemble themselves before the viewer's eyes, structure by structure. Watch the video with Johnson at http://realmedia.oit.duke.edu/ramgen/news/brain_imagi...Scientists follow familiar TRAIL to new cancer therapy
... human cancers. Potency and lack of toxicity to normal tissues make activation of TNF-a-related apoptosis-inducing ligand (TRAIL) death receptor signaling an attractive and exciting target for cancer therapy, and it is currently being tested in clinical trials. However, most cancer cells have defects in ...Scientists gain important insights into acute promyelocytic leukemia
... that interferes with gene expression and prevents normal differentiation of white blood cells. Previous work of these two groups suggested that PML/RARA self-association, called homodimerization, and posttranslational modifications are important for transformation. In addition, retinoid X receptor (RXR) ha...Penn researchers discover how microRNAs control protein synthesis
...nterference by inhibiting gene expression. Under normal conditions, the initiation of protein synthesis is...results in competition with eIF4E and disrupts the normal initiation process of protein synthesis. By improving understanding about how miRNAs control prot...Double identities lie behind chromosome disorders
...rs. Aberrant chromosomes orientate themselves like normal chromosomes, and this ability to adopt double identities protects them from detection by the control centre. We believe that this new fundamental mechanism can help to explain why chromosome disorders are so common in female sex cells, says Profess...Pumpkin: A fairytale end to insulin injections?
...8% fewer insulin-positive (beta) cells compared to normal healthy rats (Journal of the Science of Food and Agriculture, 87(9) 1753-7 2007). Xia says: pumpkin extract is potentially a very good product for pre-diabetic persons, as well as those who have already developed diabetes. He adds that although ins...A gene that protects from kidney disease
...and changes in its architecture occur which affect normal kidney function. To find out if GLIS2 has the same effect in humans Friedhelm Hildebrandt and his team at the University of Michigan carried out a genetic screen of patients suffering from NPHP. They found that like the mouse model some patients ca...Study advances vCJD prion detection
...infected human brain tissue extracts prepared from normal human platelets - a type of blood cell essential for clotting. The sample is incubated and exposed to repeated rounds of ultrasound, which break the prions up into more numerous smaller particles. The research was carried out by the University ...Specific type of cell death may accelerate decompensated heart failure
DALLAS Autophagy, a normal process by which cells eat their own proteins to p...tophagy is a highly regulated process that plays a normal role in cell function. It appears to be an adaptive response that protects the body in times of stre...Tracing Parkinson's lethal mechanism
...articular importance since Cdk5 is thought to have normal beneficial roles in neurons and modulating a relevant downstream target rather than Cdk5 directly may be a better therapeutic strategy with regard to this pathway. ...Investigating Life in Extreme Environments report gives hints on facts of life
...s setting into becoming extreme conditions for the normal ecosystems (e.g. acidification of the oceans). Therefore the understanding of tolerance/adaptation/non-adaptation to extreme conditions and ecosystem functioning are able to help predicting the impact of global change on biodiversity. This report is ...Variant CJD -- Prion amplification breakthrough brings new insights and hopes for a blood test
...s can be amplified from brain tissue samples using normal blood cells to improve the sensitivity of current ...disease (CJD) seems to result from conversion of a normal protein in the body to an abnormal form that is self-replicating as a prion and toxic to the brain. ...Pre-implantation genetic screening reduces both ongoing pregnancy and live birth rates in over 35s
... could lead to the transfer of embryos that appear normal but are in fact abnormal for one or more chromosomes not tested. Finally, many embryos resulting from IVF may be mosaic, where a single cell does not properly reflect the chromosomal composition of the whole, so that chromosomal analysis may not be...Link between immune system and mammary gland could shed new light on breast cancer
...erstand the processes involved as it is when these normal developmental events go wrong that we are at risk of cancer developing....... injured cells. They are also found in the mass of normal cells that mix with cancer cells to make up a soli...il (5-FU), which can produce toxic side effects in normal cells. They expanded the number of mesenchymal stem cells in the laboratory and then used a retrovir...Alzheimer's prevention role discovered for prions
...and vCJD, has been identified. It appears that the normal prions produced by the body help to prevent the pl...ferent conditions. They found an apparent role for normal prion proteins in preventing Alzheimers disease. Our experiments have shown that the normal prion...Study examines cause of hearing loss for patients with certain genetic disease
...curred in none of the 17 ears with gradual SNHL or normal hearing. Tumor size was not related to SNHL. Based on the relationship between the imaging and clinical findings in these patients, 3 distinct mechanisms (either alone or in combination) may account for the audiovestibular [hearing and balance] mor...Cloning the male genome may help infertile men
...e were able to propagate it, while maintaining its normal chromosomal make-up, its ability to fertilise and ...other mice, and so far 4 offspring have grown into normal adults, said Professor Takeuchi, therefore proving that it is possible to replicate the male genome,...New research holds promise for protecting cancer patients against infertility
...function was suppressed, but that this returned to normal after chemotherapy stopped. Follicle stimulating hormone levels were up in 73% of the patients, but these also subsequently returned to normal. 94% of the patients resumed spontaneous ovulation and menses within 12 months. We believe that using...