MIT researchers reverse symptoms in mice of leading inherited cause of mental retardation
... numbers and shapes of dendritic spines are key to normal brain function. FXS patients have higher numbers of dendritic spines in their brains, but each spine is longer and thinner, and transmits weaker electric signals, than those in non-affected individuals. When the enzymatic activity of PAK was inhibi...TU Delft tracks the influence of a cancer inhibitor on a single DNA molecule
...ly causes the TopoIB protein to reside longer than normal on the DNA molecule, disturbing the cell division and damaging the (cancer) cell. But the Delft researchers have now discovered to their surprise that adding topotecan also dramatically impedes the unwinding and that DNA loops accumulate as a result....Modified mushrooms may yield human drugs
... cells to hygromycin. The antibiotic kills all the normal cells, separating out those that have been genetically altered for resistance. The test demonstrates that if a second gene, insulin for example, were to be patched in the plasmid, that gene would be expressed as well. "There is a high probability ...Targeting key proteins of carcinogenesis
...proteins are the key to the effects of Ub both in normal and malignant cells. Dikic and his coworkers demonstrated that proteins equipped with an UBD can ubiquitinate themselves by directly recruiting Ub-loaded E2 enzymes thus making E3 ligases dispensible. In their previous work Hoeller and Dikic showe...Pregnancy nausea/vomiting may indicate lower risk of breast cancer
...between these hormones are not maintained within a normal range, certain pregnancy-related outcomes may emerge, such as high blood pressure, glucose intolerance and gestational diabetes, eclamptic conditions with seizures and/or toxemia, or extremely severe nausea. These pregnancy-related factors may s...Researchers isolate new risk marker for overweight children
...pically high in overweight adults, remained in the normal range. In discovering high levels of apoB48 in these children, the researchers believe they've found a new and important clue to better understand how some adults are more susceptible to cardiovascular disease (CVD) than others. "We don't consid...JCI table of contents: June 21, 2007
...traocular pressure (IOP) is not a symptom [e.g. in normal tension glaucoma (NTG)] and in other cases a reduc...e of glutamate transporters in the pathogenesis of normal tension glaucoma Author Contact: Kohichi Tanaka Tokyo Medical and Dental University, Tokyo, Japan...Autism-related proteins control nerve excitability, researchers find
...ctivity levels of neurons play a vital role during normal brain development in children. Active connections ...The two neuroligins have complementary roles under normal conditions, with neuroligin-1 increasing the excitatory links between nerve cells, and neuroligin-2 ...Researchers pit novel version of common virus against cancer
... to destroy neighboring cancer cells while leaving normal cells alone, Kim said. When the job is done, the adenovirus should die out. Side effects should be minimal. Since the adenovirus does not contain toxic elements, the worst-case scenario would be that it would cause an infection in the bodys healthy...New tumor markers -- 'Spot the differences'
...s only specific messages at any one time. While in normal cells this process is carried out following an org...ages obtained from tumour cells with the ones from normal cells. As we do when we solve Spot the difference puzzles, we try to find out what makes drawing A d...Surprising origin of cell's internal highways
...hese drugs influence cancer cells differently than normal cells," said Kaverina. "Both microtubule regulation of proliferation and microtubule regulation of migration and invasion probably contribute to the therapeutic effects." Therefore, further study of this new subset of microtubules might offer insi...St. Jude shows gene test not needed if cancer drug given in low doses
... switch that triggers the reading of the gene. The normal UGT1A1 has six copies of TA in front of it, while ...ors. A total of 27 children had both copies of the normal gene UGT1A1 with six copies of TA in the promoter region; 36 had one normal and one UGT1A1*28 gene w...Scientists ponder plant life on extrasolar Earthlike planets
...d edge effect. Seen at 700 nanometers out, where normal human vision quits working, this reflectance spectrum is a signature of the fact that there is very intense chlorophyll absorption going on. A third way yet to find extrasolar planets is to look for wobbly stars because as the planet especial...Bee researcher at Arizona State University is 1 of 20 new Pew Scholars in the biomedical sciences
...idative brain damage is a fundamental pathology in normal human aging and in Alzheimers and Parkinsons disease, and development of novel treatments has high priority in biomedical research, says Amdam. Although she describes this line of discovery as risky, its prospective contribution is of considerable re...Researchers demonstrate way to control tree height
...ble to create miniature trees that look similar to normal trees but after several years of growth may range...pread, because they would compete very poorly with normal or wild trees. In virtually all tree species, low height is a disadvantage as trees compete for suns...Promising protein may prevent eye damage in premature babies
...retina. But if we can increase the protein to more normal levels in premature babies, it should result in he...e retinas, they found blood vessels were closer to normal in eyes treated with IGFBP-3. When UF scientists repeated the experiment in 18 mice treated with b...Changes in chromosomal constitution of preimplantation embryos suggest caution in genetic screening
... 5 some of them had undergone self-correction into normal embryos. Others kept the same abnormalities, whil...led IVF cycles, been checked for and found to have normal chromosomal make-up, and produced more than 6 good quality embryos. Even in cases that fulfil these ......t to see what goes wrong, thus revealing the genes normal function and how disease makes it malfunction. But...d. The offspring mouse, in turn, is bred with a normal mouse. In a remarkably high average of 10 percent of the offspring, the desired large stretch of DNA...Noninvasive screening in early pregnancy reduces Down's births by 50 percent
...eck area of the fetus. If there is more than the normal amount of fluid the risk of Down syndrome is increased. Likewise if there is a certain combination of serum markers in the maternal blood test, taken at the same time, there is the possibility of an increased risk of a chromosomal abnormality. The ...Gum disease in postmenopausal women linked to oral bone loss
...t to be strongest in overweight women, compared to normal weight or obese women. We expected to see an increased risk for oral bone loss with increasing body mass index (BMI, a factor representing the relationship of weight to height), commented Renee Brennan, Ph.D., research assistant professor of social...