UD awarded $11M for osteoarthritis research and unique mentoring program for women scientists
...cterize the movement of molecules through bones in normal and osteoarthritic joints. Lynn Snyder-Mackler, Alumni Distinguished Professor of Physical Therapy and director of the Graduate Program in Biomechanics and Movement Sciences at UD, is leading a research team to determine if rehabilitation that norm...Cancer stem cells similar to normal stem cells can thwart anti-cancer agents
...have shown share the same protective mechanisms as normal lung stem cells. They are presenting this ground-b... and dyes to identify cancer stem cells as well as normal adult stem cells and their progeny in samples obtained from normal lung and lung cancer tissue sampl...CSHL scientists successfully target tumor microenvironment to stop cancer growth
...SKCC) and were able to remove EPCs without harming normal blood vessels. This has significant clinical potential, particularly in fighting cancer re-growth after incomplete surgical resection or chemotherapy. The exciting news is that targeting such a minor population of the BM-derived tumor microenvironm...UVa researchers restore genes in human inner ear cells
... projections that line the cochlea. In people with normal hearing, hair cells convert sound into electrical signals, which are ultimately transmitted to the brain. People with hearing loss suffer from too few, damaged or missing hair cells. Holts past research uncovered the speed at which hair cells develo...St. Jude study yields secrets of chromosome movement
...s insight into how each daughter cell receives the normal number of chromosomes; and it offers important clu... it had already established. These yeast cells had normal chromosome movement during cell division. The investigators then showed that the same yeast cells...Pre-cancerous blood diseases can be products of their environment
...tance, the findings provide an explanation for why normal blood-forming stem cells transplanted into patients with the myeloproliferative condition sometimes take on the characteristics of the disease they were meant to cure. At the moment, most doctors focus only on the blood cell as being the cause of t...University of Pittsburgh researchers culture blood-forming stem cells from human fat tissue
...ls that give rise to them, are an integral part of normal adipose tissue, according to Dr. Donnenberg. We took cells from the stromal vascular fraction of normal adipose tissue and basically gave them bone marrow food to see what would happen. We were able to cu...JCI table of contents: June 14, 2007
... while progesterone supplementation at higher than normal pregnancy levels enabled progesterone receptor sig...levated to achieve successful term pregnancy and a normal litter size. In summary, the data reflect that the indispensability of FKBP52 in uterine progester...Screening approach leads to discovery of gene linked to breast cancer
... a set of 354 human kinases and injected each into normal epithelial cells to see if any mimicked PI3K's ability to transform them into cancer cells. They found five that did. To narrow this field, investigators conducted a second group of screening procedures. Using a variety of genome-scale approaches, ...LIAI researchers identify a potential role for retinoic acid in autoimmune and inflammatory diseases
...more of the substance than they would have through normal body processes. This suppressed the formation of pro-inflammatory T cells in the intestines of the mice, demonstrating that increases in retinoic acid reduced inflammation. In another approach, designed to test how reducing retinoic acid would affe...UVa-led team uncovers important secret in gene replication
... studied, the HeLa cervical cancer cell line and a normal cell line (lymphocytic cells). To our surprise, what the HeLa cells were predicting in terms of chromatin packaging held true in the lymphocytes, even though the HeLa cells are cancer cells with scrambled genes, Dutta said. The chromatin packaging pr...Other highlights in JNCI, June 12
...ma cell lines, in samples from glioma patients and normal brain tissue, and in mouse models. They found that the overexpression of the CCRK gene was associated with a greater risk of developing glioma and increased tumor growth, whereas suppression of the gene was associated with the inhibition of tumor ...OSA symptoms more common among African-American women than Caucasians
...s in breathing that characterize OSA and restoring normal oxygen levels. ...Breakthrough developments in rheumatoid arthritis reported
...effort to release large amounts of genetic data on normal subjects for use by the scientific community. A ke...icists is the costs of obtaining genetic data from normal control populations to use for comparison to the genetic variation seen in people with disease. ...Tumor vessels identified by unique molecular markers
...urrent vascular-targeted therapies may also damage normal growing blood vessels. This is a concern because t...distinguish between proliferating blood vessels in normal and diseased tissues. The researchers systematically examined gene expression patterns in the end...Researchers identify fifth gene responsible for Joubert syndrome
...advances will lead to better understanding of both normal and abnormal brain development and eventually improved treatments for a variety of diseases. Ongoing genetic research at Seattle Childrens Hospital Research Institute will look for additional mutations responsible for Joubert syndrome, and continu...Cancer stem cells can go it alone
...ancer stem cells for destruction while leaving the normal stem cells in the body intact, hopes Zucchi. Dul...le stem cell potential and, therefore, behave like normal adult stem cells. But it wasnt until later that we could demonstrate that a single LA7 cell can also...Identification of genetic risk factor for coeliac disease promises improved treatment
...e - which results in damage to the gut, preventing normal digestion and absorption of food. If undetected it can lead to, amongst other things, anaemia, poor bone health, and weight loss. Although the majority of people are diagnosed in mid-life, symptoms can present themselves at anytime, for example duri...Now playing -- Cell migration LIVE!
...ance could lead to strategies for controlling both normal growth and the spread of cancer, processes that depend on the programmed, organized movement of cells across space The stars of our live show are a cluster of fruit fly cells that literally crawl across the length of an egg chamber while it is mat...Dartmouth professor makes case for ethically universal stem cell lines
...lanted in the uterus. Since many people regard the normal human blastocyst as morally deserving of protectio...blastocyst intact and unharmed or avoid the use of normal blastocysts in the first place. The paper explains the science behind the six approaches and desc...