Antibody-based therapies effective at controlling malaria
...al PLoS Pathogens. The researchers developed these novel reagents by antibody repertoire cloning generated ...abor-intensive and difficult to reproduce. These novel human reagents cured mice of an otherwise lethal malaria infection, and protection was crucially dep...Ocean observing contracts awarded to UC San Diego and University of Washington
...This new ocean observatory capability will provide novel and enduring ways to study the oceans. These new approaches are going to revolutionize not only how we humans look at oceans and the earth, but eventually in the time of our children's children the way we manage our entire planet," commented Profes...Genome of yellow fever/dengue fever mosquito sequenced
...provides a strong incentive to explore and develop novel control strategies that efficiently disrupt the transmission cycle or enhance existing strategies. The Ae. aegypti genome sequence is expected to stimulate efforts to elucidate interactions at the molecular level between mosquitoes and the pathogens ...Executable biology -- Computer science sheds light on animal development
...er to determine the fates of individual cells. The novel in silico model is described in a paper appearing May 18, 2007 in the open-access journal PLoS Computational Biology. During C. elegans development, uncommitted precursor cells differentiate into two distinct cell types in response to a series of ...Newly identified mechanism for silencing genes points to possible anti-cancer strategies
...otein production, may be operating in a completely novel way to prevent genes from producing proteins. MicroRNAs have been implicated in a number of cancers, and the newly outlined gene-silencing mechanism offers promising potential targets for anti-cancer interventions. "Some microRNAs closely match the...First demonstration of new hair follicle generation in an animal model
...better understanding of this process could lead to novel treatments for hair loss, other skin and hair diso... manipulate hair-follicle regeneration, leading to novel ways to treat hair loss and hair overgrowth. These findings go beyond just a possible treatment fo...Pediatric cancer stem cell identified: understanding the origin of ERMS
...o identify both an ERMS tumor-cell-of-origin and a novel genetic signature that underlies ERMS progression in zebrafish and human patients. Cancer stem cells make up only a small fraction of the overall number of cells in a tumor. However, they are capable of giving rise to other cancer cells, and thereby ...DNA analysis suggests under-reported kills of threatened whales
... number of whales in trade, the researchers used a novel model for "capture-recapture" analysis characterized by DNA profiles from each slice of whale meat which was developed by one of the co-authors of the study, Justin Cooke at the Center for Ecosystem Management Studies in Gutach, Germany. Although c...Other highlights in the May 16 JNCI
...he possibility that FLIP is a potential target for novel anticancer therapies," the authors write. Contact: Jane Finlayson, senior public affairs advisor, Princess Margaret Hospital, (416) 946-4501 ext. 2846, Jane.Finlayson@uhn.on.ca...Woods Hole Research Center scientists using remote sensing tools to predict bird species richness
...Center and the University of Maryland have taken a novel approach to studying biological diversity by making use of laser remote sensing (lidar). Lidar data provide unique measurements of the 3-dimensional structure of vegetation, an important aspect of habitat diversity. Habitat heterogeneity and complex...New impetus through networking
...coordinated, geographically distributed funding in novel areas. Priority Programmes generally run for a period of six years. The new Priority Programmes: The role of ubiquitin-like protein modifications (UbF) in cells will be investigated in a project called "The Regulatory and Functional Network of...Burroughs Wellcome Fund awards $14M to support physician-scientists
...atures of oncogenic pathway deregulation provide a novel approach to targeted therapeutics in non-small cel...Ph.D. University of Pennsylvania Identification of novel genes that regulate sleep in Drosophila melanogaster ...UCSB Assistant Professor Patrick Daugherty wins Young Investigator Award from ACS
... protein engineering, including the development of novel peptide display methodologies, fluorescent protein sensors and library screening methodologies. Daugherty will deliver the Biochemical Technology Young Investigator Award Lecture at the American Chemical Society meeting in Boston in August. The aw...Toxoplasmosis infection trick revealed by scientists
...tick to, and then enter the human cell. Using a novel carbohydrate microarray the team were able to identify the precise sugars to which the parasite protein binds. Following this the team used a combination of NMR spectroscopy and cellular studies to characterise the behaviour and interactions of the p...DNA repair proteins monitored at double-strand break
...t can go wrong with DNA repair. This could lead to novel ways to make cancer cells more sensitive to therapy by blocking their ability to repair double-stranded breaks caused by chemotherapy or radiation. It could also suggest new strategies for enhancing repair of double-stranded DNA caused by radiation, ...InfoSNM highlights advances in computer, information sciences for molecular imaging
...programs on information science and technology and novel uses of computers in research and education as wel...ssionals do every day," he added. From June 35, novel researchfor the clinic or research labwill be presented in six computer presentation sessions. Times...Gene mutation linked to cognition is found only in humans
...nstrated the molecular mechanism that creates this novel protein, will be published online in Human Mutatio...only necessary but also sufficient in creating the novel splice form," the authors state. The results also showed a weakening effect of a different, type...Biosensor sniffs out explosives
... is the first to identify, clone and sequence this novel olfactory receptor. "We suspected that harnessing the potential of the olfactory system, which can detect innumerable chemical agents with unparalleled sensitivity and selectivity, would be of immense value in the detection of environmental toxins ...Global heartbeat control suggests therapy for beating heart failure
...obal orchestrators of heart function might offer a novel approach to managing diseases of the heart muscle,...ugs targeting ERR receptors might hold promise for novel heart therapies. "There are not many ways to prevent heart failure, but molecules that act on these ...Fat screen delivers plant-derived chemical with antidiabetic effects
...sue by distinct mechanisms could be candidates for novel insulin sensitizers. By running a technologically advanced screen of more than 500 bioactive compounds, the researchers found that harmine has such a positive effect on fat. The fat cells under examination were manipulated such that they literally li...