High blood pressure, low energy -- a recipe for heart failure
...r biology and pharmacology. ERR alpha sits in the nucleus of cells and senses how much energy is needed. When a heart cell finds itself short on energy, say because it's being called on to contract harder or faster, its ERR is activated by an inducible co-activator called PGC-1, turning on genes that increa...New, more direct pathways from outside the cell-to-cell nuclei discovered
...pathways from the extracellular environment to the nucleus in the one-celled protozoan Tetrahymena thermophil...e arrival of the phagosomes and their loads at the nucleus was marked by the illumination of the nucleus by the beads. Similarly, the researchers also labeled ...News tips from the Journal of Neuroscience
...d Anderson propose the inferior colliculus central nucleus (ICC) as an alternative site for auditory prostheses. For such devices to work, it is necessary to stimulate at sites that tap into the tonotopic organization of the auditory system; but there's more. In this week's Journal , the authors reveal a pr...Scientists prove that disputed Korean stem cell line comes from an unfertilized egg and not cloning
...are derived from embryos that are created when the nucleus of an egg is replaced by the nucleus from a body cell. Creation of human ntES are pES are of particular interest to researchers as they m...Discredited Korean embryonic stem cells' true origins revealed
...rough somatic cell nuclear transfer (replacing the nucleus of an egg with the nucleus from a cell in the body). They also tested three human embryonic stem cells isolated from fertilized......curs or "in the shop" at specific regions of the nucleus is an unanswered question. That question may n...dicate the severity of the damage, or where in the nucleus the double-strand breaks occur. The default assumption has been that DSBs occur randomly in a homoge...Altering a protein makes mice less fearful
... including the amygdala and an area called the bed nucleus of the stria terminalis (BNST), which is thought to be particularly important for innate fear behaviors. The study also shows that mice without ASIC1a have altered neuronal activity in these fear circuit structures. The researchers speculate that b...How a pain in the neck could be bad for your blood pressure
... Hungary, found a link between these cells and the nucleus tractus solitarius, an area of the brain that is pivotal in control of autonomic functions - body functions under unconscious control. They propose that nervous signals from the neck could play a key role in ensuring that adequate blood supply is mai...JCI table of contents: August 1, 2007
...lping us understand how a red blood cell lacking a nucleus knows exactly when to die." TITLE: FoxO3 is required for the regulation of oxidative stress in erythropoiesis AUTHOR CONTACT: Saghi Ghaffari Mount Sinai School of Medicine, New York, New York, USA. Phone: (212) 659-8271; Fax: (212) 803-6740; E-ma...Chickens dieting to help Delaware waterways
... an industry cooperator. Phytase has been at the nucleus of industry cooperation and regulations to deal with nutrients, William Rohrer Jr., administrator of the Delaware Nutrient Management Program, said. It has significantly reduced the phosphorus going into our waterways. The University's phytase rese...Prenatal stress keeps infants, toddlers up at night, study says
...rve cells in the brain called the suprachiasmatic nucleus which act as a signaling system that tunes bodys internal clock. This signaling system helps to properly regulate daily rhythms of waking, sleeping, even hunger that is, if its formation has not been disrupted. This could explain why sound sleep...Research study describes the role part of the brain plays in memory
...s commanded by a specific region of the brain, the nucleus basalis magnocellularis (NBM), which produces acet...essential in making the memory work correctly. The nucleus basalis magnocellularis equivalent in humans is the nucleus basalis Meynert. Precisely this is one o...News tips from the Journal of Neuroscience
...an proteins mPER1 and mPER2 in the suprachiasmatic nucleus (SCN). In slices, however, the electrophysiological and molecular clockwork of the SCN appeared intact in R6/2 mice, suggesting that the intrinsic SCN circuitry was functioning normally. Hypnotic doses of sedative drug normalized the sleepwake cycle ...Scientists take next step in understanding potential target for ovarian cancer treatment
...g a messenger protein that tells components in the nucleus to stop cell growth. The discovery of this additio... TGF-signaling component that must get to the cell nucleus to turn on specific genes that help stop cell growth. Alterations in the TGF signaling system are...Chromosome glue repairs damaged DNA
...on, whereby two copies of a chromosome in the cell nucleus are held tightly together by a protein complex called cohesin. Cohesion fulfils an important function during cell division as the newly copied chromosomes, the sister chromatids, have to stay together until the right moment of separation. If the chro...News tips from the Journal of Neuroscience
...escent protein)-labeled Bassoon accumulated at the nucleus rather than moving down axons along microtubules. ...ocrine neurons in the paraventricular hypothalamic nucleus (PVH) respond to hyperglycemia with synthesis and release of corticotropin-releasing hormone (CRH). ...Cloning the male genome may help infertile men
...ealthy mouse sperm into a mouse egg from which the nucleus had been removed, and by doing so cloned the male ...ide the opportunity to use replicates of the sperm nucleus for diagnostic purposes. If you only have one healthy sperm you would be reluctant to use it for a...Gene therapy study shows safety and statistically significant improvement in Parkinson's disease
...tamic acid decarboxylase or GAD) to the subthalmic nucleus (STN) of the brain. In Parkinsons disease, STN activity is abnormally increased, largely due to a deficit in GABA (gamma-aminobutyric acid), the major inhibitory neurotransmitter in the brain. Increasing GAD causes more GABA to be synthesized, thus h......s" must be anchored at a structure near the cell's nucleus called the centrosome or microtubule-organizing center (MTOC). From the MTOC, the growing microtubules launch out in all directions to the cell's periphery. Their rapid assembly and disassembly helps transport proteins throughout the cell and gene......e responsible for folding and packing DNA into the nucleus of each cell. Five percent to 50 percent of DNA is considered useless junk, depending on who you ask, although probably at least half of the junk DNA is going to end up having a pretty important function, Capecchi says. Capecchi is known for de...