Tag: "nucleus" at biology news
Homeoprotein DNA-binding specificity
...s to understand how the "address" of a gene in the nucleus
contributes to its differential regulation."...
Human albumin from tobacco plants
...ion method, it integrates into the DNA of the cell nucleus
of the leaf and, thus, can only manage a small number of copies of the gene. With the plastidial system, on the other hand, the gene is introduced into the chloroplast, where photosynthesis takes place and where the genomes can multiply up to 10,000 ...
Targeting the dosage compensation complex
...ome from the other 7chromosomes chromosomes in the nucleus
has remained a mystery. As published in G&D, the labs of Drs. Mitzi Kuroda and Peter Park (Harvard Medical School), Peter Becker (University of Munchen) and Asifa Akhtar (EMBL) have usedused used chromatin immunoprecipitation combined with high-throu...
A balancing act between the sexes
...nk discovered between the membrane surrounding the nucleus
and the male X-chromosome in fruit flies may play ...ion. "The nuclear membrane and the gateways to the nucleus
are central meeting points in the cell where many different pathways overlap", says Jop Kind, a rese...
Pepper component hot enough to trigger suicide in prostate cancer cells
...with normal movement of androgen receptor into the nucleus
of the cancer cells where the steroid receptor acts to regulate androgen target genes such as prostate specific antigen (PSA). Capsaicin also interfered with the action of androgen receptors even in cells that were modified to produce excess numbers ...
Researchers unravel DNA tangles and enzyme seamstresses
...puter simulations to mimic the DNA mess inside the nucleus
with a series of billions of linked and unlinked loops. Their calculations indicated that whether DNA molecules are interlinked is shown by the way they touch each other. Interlinked DNA loops tend to touch in an easily recognizable hook-like way, fi...
For the first time: Longevity modulated without disrupting life-sustaining function
... DAF-2 is active, it is unable to enter the cell's nucleus
to activate its target genes. When environmental conditions turn harsh as a result of overcrowding and scarce nutrients, for example, DAF-2 signaling shuts down. No longer marooned outside the nucleus, DAF-16 crosses into the nucleus, and triggers al...
Worm hormone discovery may aid fight against parasitic disease
...e newfound ligand binds to a protein in the cell's nucleus
called a nuclear receptor, a receptor designated DAF-12. Once that binding occurs, DAF-12 activates other genes that allow the worm to develop through its normal stages, reach maturity and reproduce. When the researchers blocked that hormonal signal...
Joslin researchers reveal mechanisms behind a class of oral agents used to treat type 2 diabetes
...ugs work primarily by binding to a receptor in the nucleus
of cells called Peroxisome Proliferator Activated Receptor-gamma (PPARg), all of the molecular signaling events important for the drugs to work are not completely understood. A new study by researchers at Joslin Diabetes Center in Boston helps to ex...
'Shuttling' protein possibly key to resilience of cancer cells
... protein previously believed to be confined to the nucleus
of healthy cells actually shuttles between the nucleus
and cytoplasm, the region of the cell surrounding the nucleus. Moreover, the protein's shuttling is ...
New cell imaging method identifies aggressive cancer cells early
...hat illuminates a specific protein within a cell's nucleus
may be a key to identifying cancer virulence and t...breast cells - the organization of proteins in the nucleus
varies tremendously," Lelivre said. "Then looking at how the proteins in malignant cells are distrib...
JCI table of contents, February 16, 2006
... mutant form of FoxO1 that is always active in the nucleus
of the beta cells and found that the proliferation...suggest that continuous expression of FoxO1 in the nucleus
of beta cells prevent their hyperplasia, and can accelerate the onset of diabetes, even in the prese...
Waking a sleeping virus
...ing an infection, EBV inserts its own DNA into the nucleus
of human cells. This information contains the codes for about 100 genes," says Christoph Mller, head of an EMBL research lab in Grenoble. "Less than 10 genes are sufficient for the virus during its latent state, whereas all others are necessary to pr...
Social stress in mice is controlled by genetic pathway, researchers find
...center in the primitive part of the brain, and the nucleus
accumbens, a small area in the front part of the b...entral tegmental area, but a minimal amount in the nucleus
accumbens. The defeated mice showed an increased amount of BDNF in the nucleus
Mice lacking social memory molecule take bullying in stride
... expression in the target area of the circuit, the nucleus
accumbens, located deep in the front part of the brain 309 genes increased in expression while 17 decreased. This pattern persisted even 4 weeks later, with 127 genes still increased and 9 decreased, paralleling the changes seen in social behavior. ...
Removing DNA repair gene causes metabolic syndrome
... has been shown to be localized in both the cell's nucleus
and its power plant, the mitochondria, pointing to...mage to the genetic material, whether it is in the nucleus
or whether it's in the mitochondria, is what's leading to a destabilization of a normal metabolic pr...
New brain hormone puts brakes on reproduction
...wer: Estradiol stimulates cells in the dorsomedial nucleus
of the hypothalamus to produce GnIH, which appears... GnIH are in an area of the brain, the dorsomedial nucleus
of the hypothalamus, that coordinates and integrates information from external stimuli, the senses a...
Scientists find genetic pathway that could lead to drugs for kidney disease
...tops, and the transcription factors migrate to the nucleus
of the cell, signaling the cell to divide to replace those cells that have been lost. In patients with this disease the repair mechanism is always turned on because the polycystin-1 is defective, or mutated. The discovery of this pathway thus opens t...
Hi ho silver! FSU physicist helps discover an atomic oddity
...ission of one of three types of particle: a helium nucleus
consisting of two protons and two neutrons, an electron or a photon. Exotic atoms engineered to contain fewer neutrons than in the atom's natural state were expected to break down by emitting protons one at a time. But the correlated two-proton decay...
Swiss researchers develop all-in-one remote control gene expression tool
...entiviral vector joins the genetic material in the nucleus
of the cell, causing the cell to express the protein encoded by the new gene. This versatile package can also carry bits of RNA that stop the cell from expressing one of its own genes, by way of RNA interference. But the cargo that makes this tool re...
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