Is Interleukin-6 the 'holy grail' of exercise mediation?
...levels of TNF-alpha and IL-6 have been observed in obese individuals, smokers and patients with non-insulin-dependent diabetes mellitus but there's no evidence that either is actually the source of these problems. Indeed, it's possible, for instance, that IL-6 expression may be up-regulated in insulin resi...New genetic tools provide clues to the effects of exercise and diet on obesity, diabetes
...ssion and protein profiles from muscle of lean and obese and morbidly obese individuals. "This combination of genomic and proteomic techniques may help determine the effects of...Obese women with early-stage breast cancer more likely to die than women of normal weight
Women who are obese when they are diagnosed with early-stage breast ca...early stage disease, which is more commonly cured, obese women more often developed metastatic disease and more often died." The influence of obesity on brea...Biological importance of basal activity of appetite suppressor
...tic study of naturally occurring MC4R mutations in obese patients. By genetically transferring normal or mutant versions of the MC4R gene into cells in culture, the authors were able to define a cluster of mutations at the N-terminal end that impaired the constitutive activ-ity of MC4R. Deletion of the N-t...Scientists identify new cause of obesity
... appetite. Pioneering genetic studies of extremely obese people carried out since 1998 by Christian Vaisse,...single treatment is likely to be effective for all obese people. Still, MC4R must be a central player, he says, since mutations that cause even subtle change...Study: Inadequate physical activity worsens as teenagers become adults
...greatest risk of being significantly overweight or obese and inactive." In the new research, she and colleagues wanted to concentrate on possible changes in physical activity between adolescence and young adulthood since few scientists have studied what happened to activity levels over that part of t...Fat buildup found in hearts of obese or diabetic heart failure patients
HOUSTON (Nov. 1, 2004) -- Diabetic or obese patients suffering advanced heart failure have hig...des in failing hearts were four times the level in obese or diabetic patients as they were in non-failing hearts. The research team associated this buildu...A new target for control of obesity
... worldwide. Although it is commonly believed that obese individuals can overcome their condition by simply eating less and exercising more, compelling scientific data suggest that the heritability of obesity is greater than breast cancer, heart disease, or schizophrenia. Morbid obesity is considered as t...Young adults who maintain their weight have lower risk factor levels for heart disease
...am but excluded those who were underweight or very obese at the start of the study. The study examined the relationship over time between weight and several cardiovascular disease risk factors: high blood pressure, high glucose (sugar) levels which can indicate risk for diabetes, high triglyceride levels, ...Hold the stuffing: Low-glycemic diet may help keep weight off
... Ludwig and colleagues randomized 46 overweight or obese adults aged 18 to 40 to consume one of two diets: a standard low-fat diet or a low-GL diet. Both diets provided approximately 1500 calories/day and were designed to produce a 10% weight loss in 6 to 10 weeks. However, the low-GL diet was higher in f...Stanford study links obesity to hormonal changes from lack of sleep
...ur hours a night were 73 percent more likely to be obese than normal sleepers. Researchers believe that sleep loss impacts several hormones related to appetite and food intake, and two such hormones - ghrelin and leptin - are thought to play a role in the interaction between short sleep duration and hig...Fewer calories may slow Alzheimer's
...Alzheimer's disease, according to a USCstudy. With obese people generally considered to be at a higher risk fordeveloping Alzheimer's, the research raises questions about whetherthe findings are potentially applicable to humans. "This is the first indication that modest changes in the normal dietcan slo...JCI table of contents, December 15 2004
...om Osaka University, Japan, show that fat cells of obese mice produce increased levels of toxic oxygen molecules known as reactive oxygen species (ROS) as well as the enzyme NADPH oxidase. Furthermore, these cells express decreased levels of antioxidative enzymes that are responsible for destroying these t...Oxidants link obesity to diabetes
...om Osaka University, Japan, show that fat cells of obese mice produce increased levels of toxic oxygen molecules known as reactive oxygen species (ROS) as well as the enzyme NADPH oxidase. Furthermore, these cells express decreased levels of antioxidative enzymes that are responsible for destroying these t...UCLA/VA researchers discover fat gene
... lipin in their fat tissue or muscles quickly grew obese gaining more than twice the weight gained by the ...at. The mice with more lipin in their muscle grew obese because the gene repressed their metabolism, causing them to burn fewer calories than normal mice. I...Plant protein mimics hormone that mitigates diabetes and obesity
...dition, adiponectin levels tend to be lower in the obese and in patients with heart disease than in healthier individuals. Whether the beneficial effects of adiponectin can be induced by osmotin is currently unknown. "We've shown the connection between adiponectin and the plant protein osmotin," Bressan sa...Lack of enzyme turns fat cells into fat burners
...ing weight, while their normal counterparts become obese and develop type 2 diabetes. "This adds another tissue or organ that helps out in the process of energy maintenance," said Wakil. "ACC2 is potentially a key enzyme in the regulation of weight, obesity, and related problems." Wakil and his colleagues ...By age 6, children of overweight mothers are also prone to obesity
...weight mothers are fifteen times more likely to be obese than children of lean mothers. The research, at The Children's Hospital of Philadelphia and the University of Pennsylvania, showed the strength of genetic influences, and suggests that efforts to prevent obesity should focus on such children at risk,...Diabetes' link to obesity broken in mice
...rsing the alteration produced mice that can become obese but do not develop diabetes. The findings provide ...d the reverse was true. The mice could get just as obese as normal mice on a high-fat diet, but they did not develop early signs of diabetes. Based on what t......onditions are linked, and what it takes to turn an obese person into a person with diabetes. Today, resear...that link -- and may help them understand why some obese people never develop diabetes while many others do. The study, published in Cell Metabolism, suggest...