Genomic signatures identify targeted therapies for lung cancer
...r activity. Rather than looking at each of these oncogenes individually, this new method presents a more global view by identifying the pathway encompassing all of the gene mutations that could have caused that cancer, Potti said. The genomic test can theoretically apply to any cancer, but the Duke team fo...Asymmetry due to perfect balance
...us lead to the development of cancer. As so-called oncogenes some of the proteins activators have also been shown to cause tumour growth. The asymmetric distribution of Cdc42 in the cell membrane creates an area with elevated concentrations of that molecule, which is defined as a cap. This site is used as a ma...Enhancing chemotherapy's efficacy: New agent has synergistic effect with standard drugs
... inappropriately. The growth signals sent by these oncogenes use a well-traveled enzyme pathway called MAPK (mitogen-activated protein kinase). This pathway is responsible for cell response to various growth factors and is involved in the action of many cancer-causing genes. A number of new cancer drugs in de...Cancer cells more likely to genetically mutate
... tumor may have cells with many different types of oncogenes and drug-resistant genes. That chemotherapy drug may kill off some of the cancerous cells, but millions of other cells in the tumor will live on. To be effective, a chemotherapy treatment may have to target more than one oncogene so-called combinati...Technology captures tumors' genetic profile, guides cancer treatment
...to detect important cancer mutations. Mutations in oncogenes (genes linked to cancer) do not occur randomly; ra...ns co-occurred within tumor cells, suggesting that oncogenes often work in partnership. As promising as high-throughput genotyping is for cancer treatment and ...Genomic 'firestorms' underlie aggressive breast cancer progression
...etween 'firestorms' and the locations of candidate oncogenes and tumor suppressors in the genome. It will assist the researchers in identifying genes that drive cancer progression, and help unravel the complex yet elusive genetic pathway that underlies tumor metastasis....Why don't all moles progress to melanoma?
...e found that the ER senses the activity of certain oncogenes in the melanocyte and triggers a response that pre...being expressed in the cell. "We found that some oncogenes activated the endoplasmic reticulum, while other oncogenes didn't," Soengas says. In a previous s...Antibiotic inhibits cancer gene activity
...researchers a rapid way to find agents that target oncogenes -- genes believed to cause cancer. He said siomycin A, the first compound found with the method, "is particularly promising because we know that it is not toxic." Siomycin A must now be tested against other cell lines in the laboratory and in preli...High-throughput oncogene mutation detection in human cancers by mass spectrometry-based genotyping
...ns in genes that make them oncogenic. They chose oncogenes known to contain "dominant activating mutations in many tumor types. In a lot of cases, the entire biology of the tumor is conditioned around such mutations, so if you eliminate the oncogene, the tumor shrinks," Dr. Garraway said. Examples include th...Pinning down a cancer threesome
...pressor genes and oncogenes. The overexpression of oncogenes disrupts complex cellular signaling pathways and leads to tumor development. However, most oncogenes also play a variety of essential roles in the normal function of a cell. It is extremely difficult t...Scientists uncover rules for gene amplification
... mimic the situation in human cancer cells wherein oncogenes might be located next to palindromic sequences. Using this system we have discovered the rules that determine how double minutes or homogeneously staining regions can be generated," said Kirill Lobachev, assistant professor in Georgia Tech's School o...Tumour development actors ERK1 and ERK2 found to play opposite roles
...nction of the Ras oncogenes, an important class of oncogenes involved in the development of many human cancers. In the absence of ERK1, ERK2 shows increased activity and it promotes both normal and Ras-dependent cell proliferation. In contrast, increased levels of ERK1 in cells significantly slow down their pr...Molecular 'brake' found for neurofibromatosis 1
...rs. The oncogene, called Ras, was one of the first oncogenes ever discovered and has been implicated in more than half of all human cancers. The new finding could have important medical implications, the researchers said, since the gene involved and the processes that regulate its activation are the same in hu...Scientists tie several cancers to common 'oncogene engine'
...t all of these tumors share this central family of oncogenes that are functionally interchangeable," said Fisher, who is also a professor of pediatrics at Harvard Medical School. His team demonstrated this point by showing that when tumors in mice were shrunk by disabling one of the transcription factors, repl...New model of p53 regulation proposed that suggests novel anticancer strategy
...Mdm4 are over-expressed to act like cancer-causing oncogenes in much of the rest. We need to know how each of these p53 inhibitors work in normal cells before we can figure out the most effective therapeutic strategies to manipulate them in cancer cells," he says. The new findings suggest that cancer drugs no...Genome changes tracked during multiple myeloma initiation, progression and treatment
...at point to a large number of yet-to-be-discovered oncogenes and tumor suppressor genes. These amplification and deletion patterns define new disease subgroups of MM that are characterized by varied dysregulation of distinct cancer-relevant genes and can be correlated with different clinical outcomes. Importan...Translational derepression & oncogene expression in breast cancer cells
...el mechanism whereby the translation efficiency of oncogenes is increased in cancer cells. The human epidermal growth factor receptor 2 (Her-2) is an established oncogene whose overexpression drives metastasis in about 25% of breast cancer patients. In the April 15th issue of Genes & Development, the researche...The American Association for Cancer Research provides support for promising cancer scientists
...le University, New Haven, Conn. Project: Potential oncogenes encoding microRNA binding proteins AACR-Cancer Research and Prevention Foundation Melanoma Research Fellowship, given in memory of H. Theodore Shore Recipient: Juan Chen, M.D., University of Miami School of Medicine, Miami, Fla. Project: Two nov...A cancer promoting protein shows up in an unexpected place in the cell
...r researchers since the late 1970s, when the first oncogenes -- genes that cause the transformation of normal c... cancerous cells -- were discovered. One of those oncogenes was ras. There are three ras genes, and K-Ras is the most important in terms of its impact on human......lated Gene (ERG) as one of most frequently altered oncogenes in prostate cancer, have led to collaborative oppo...of specificity." Through the collaboration, CPDR's oncogenes may be studied in combination with other promising prostate cancer markers owned by Gen-Probe, inclu...