New view of cancer: 'Epigenetic' changes come before mutations
...hat normally suppress cancer and the turning on of oncogenes to produce proteins that set off malignant behavior. Epigenetic changes are found in normal cells of patients with cancer and are associated with cancer risk, Feinberg notes. As one example, in a study published in the Feb. 24, 2005, online version ...Common viruses may cause cancer
... a particular "predisposing" gene mutation (in the oncogenes E1A or Myc, or in the tumor suppressor gene p53), then a significant proportion of the resulting hybrid cells were highly proliferative and thus potentially cancerous. Whether such proliferating hybrid cells are produced by viruses in the human body,...UT Southwestern scientist elected to National Academy of Sciences' Institute of Medicine
... cancer. He correctly predicted that the so-called oncogenes would also bind to DNA. More recently, he discovered a mutation in gene "switches" that causes a condition resembling schizophrenia in mice. Another project has linked mutations in genes that control the body's "clock" to several conditions, includin...Tissue stiffness drives tumor formation
...ets. "This study identifies the connection between oncogenes and the mechanics of the cell and its microenviron...e. Although researchers have long appreciated that oncogenes such as Ras and Erb2 drive cell growth via the ERK pathway, this study showed how high levels of ERK...Cancer gene MYC shown to activate gene involved in metastasis
... gene MYC is among the most commonly overexpressed oncogenes in human cancers. Most human cancers demonstrate high levels of MYC or its biological partners, including those of the breast, ovaries, lung, prostate, and skin, as well as leukemias and lymphomas. MYC is a regulator of other genes--a transcription f...Scientists find cell surface enzyme matriptase causes cancer
...eally shows is the current list of about 100 known oncogenes remains very much a work in progress," said Bugge. "It's also clear that matriptase and the approximately 200 other distinct cell-surface proteases will have a lot more to tell us about human health and disease in the coming years."...Researchers find BRCA1 tumor suppression nullified by cyclin D1
... of factors that promote tumor growth, such as the oncogenes ErB2, src, and ras. In more than half of human patients with breast cancer, tumor cells produce as much as eight times the amount of cyclin D than healthy breast cells. Cyclin D1 interferes with BRCA1 function because the two proteins both bind to th...BRCA1 tumor suppression nullified by cyclin D1 at the estrogen receptor
... of factors that promote tumor growth, such as the oncogenes ErB2, src, and ras. In more than half of human patients with breast cancer, tumor cells produce as much as eight times the amount of cyclin D than healthy breast cells. Cyclin D1 interferes with BRCA1 function because the two proteins both bind to th...Learning how leukemia comes to life
... the collaboration of two complementary classes of oncogenes in AML has direct implications for therapeutic interventions as it forms the rationale to test signal transduction inhibitors in leukemias characterized by activating mutations of receptor tyrosine kinases....Protein amplification in melanoma is possible drug target
...class of 'lineage survival' or 'lineage addiction' oncogenes required for both tissue-specific development and tumor progression," said David Rimm, M.D., an author on the study and associate professor in the Department of Pathology at Yale School of Medicine. Another Yale author on the study was Aaron Berger,......known as oncogenes; when mutated to high activity, oncogenes stimulate the cell to form cancers. But a number o...colleagues, have shown that genetic alterations of oncogenes are not, as once believed, sufficient in themselves to cause cancer. "Even activated oncogenes req...Discovery offers promising lead in prostate cancer diagnosis
...rostate cancer. The cancer-causing genes known as oncogenes and tumor suppressor genes have long been known to...eaths among men in the U.S., the identification of oncogenes and tumor suppressor genes that are altered in most prostate cancer cells have eluded scientists thu...Unchecked DNA replication drives earliest steps toward cancer
...netic triggers for cancer as mutations in specific oncogenes or tumor suppressor genes. Full-blown tumors and metastatic cancers, however, often exhibit many genetic mutations, sometimes dozens in a given tumor. An important scientific question, and one with significant clinical implications, has been what hap...Lewis C. Cantley, Ph.D., receives Pezcoller-AACR International Award for Cancer Research
...m by which PI3K is activated by growth factors and oncogenes and elucidating pathways downstream of PI3K, including the AKT/PKB signaling pathway. In the course of his work, Cantley's laboratory developed an oriented peptide library approach that has revealed the structural basis for regulated interaction of ...JCI table of contents, April 1, 2005
... events in thyroid cancer, labeling these three as oncogenes (genes that contribute to cancer). In a study appe... II explored which common genes regulated by these oncogenes participate in tumor formation. The researchers demonstrate that the three oncoproteins involved in...Why some lung cancers stop responding to Tarceva and Iressa
... lung cancers to survive. Even though many mutated oncogenes have already been found, the crucial genes are still unaccounted for in about 50 percent of non-small cell cancers," Dr. Pao said....New cancer gene identified by Memorial Sloan-Kettering scientists
...t Pokemon is unique in that it is needed for other oncogenes to cause cancer." said MSKCC cancer geneticist Pier Paolo Pandolfi, MD, PhD, the senior author of the study. "More important, because the Pokemon protein plays such a crucial role in the formation of cancer, it could prove to be an effective target f...US researchers uncover the science behind the breast cancer protective effect of olive oil
... up to 46%. Her-2/neu is one of the most important oncogenes in breast cancer," said Dr Menendez. "Moreover, in our tests, oleic acid's inhibition of Her-2/neu synergistically interacted with Herceptin-based immunotherapy by promoting the death of breast cancer cells exhibiting high levels of the oncogene. ...Researchers discover a stem-cell switch lurking within leukemias
...noteworthy because they show that certain leukemia oncogenes can commandeer and switch on genetic programs that...id Gilliland. "Our data show that certain leukemia oncogenes can commandeer programs that govern self-renewal and turn the switch back on again." One of the impl......ks structurally quite similar to the Src family of oncogenes that also produce kinases. Yet, as Kuriyan's work demonstrated, STI-571 does not inhibit the Src proteins because they maintain a different shape when in their inactivated, or "off," position. As Kuriyan prophetically stated at the time, "The puzzle ...