Blocking a premature aging syndrome with anticancer drugs
...equire farnesylation for function, like the famous oncoprotein Ras, which are now being tested in phase III clinical trials of patients with myeloid leukemia. Again, he witnessed no blebbing. More importantly, he saw the same effect when he treated cells grown from skin biopsies of HGPS patients: HGPS cell blebb...The tumor suppressor protein phosphatase 2A offsets the BCR/ABL oncogenic kinase
... case of CML, constitutive activity of the BCR/ABL oncoprotein contributes to disease progression, including the transition from the chronic phase to the highly aggressive "blast crisis" (CML-BC) phase. In this work supported by The National Cancer Institute, NIH (Bethesda, MA) and The Congressionally Directed C...Global signaling study suggests cancer link to protein promiscuity
...nding of oncogenesis -- that cancer arises when an oncoprotein becomes overactive, ramping up the biochemical pathways that it normally activates -- suggesting that an important additional mechanism could be the inappropriate activation of numerous secondary pathways. "Our data offer a new way to think about can...JCI table of contents: January 4, 2006
... same issue. TITLE : alphaB-Crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer AUTHOR CONTACT: Vincent Cryns Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USAPhone: 312-503-0644; Fax: 312-908-9032; E-mail: v-cryns@northwestern.edu . View the PDF...Mouse model reveals that oncoprotein induces abnormal preleukemic blood cell progenitors
...technique that allows induction and study of a key oncoprotein in adult mice. Previously, it was difficult to investigate this oncoprotein in the mouse, as the expression of this gene is associated with embryonic lethality, or death of the...Small molecules overcome drug resistance in cancers associated with high-risk viruses
...that are linked to the human papilloma virus (HPV) oncoprotein E6, such as cervical cancer. Certain viral oncoproteins, including HPV E6, are known to interfere with the function of a protein called p53, a key tumor suppressor involved in apoptosis. Loss of p53 is linked to uncontrolled cell proliferation, the h...Cell's fight against cancer revealed
...ation of the virus that produces LTag, known as an oncoprotein for its function in cancer growth. The champion ...his virus knows how important p53 is, and has this oncoprotein (LTag) to target it by physically interacting with it and changing its conformation," Chen said. I...Viral oncoprotein inactivation of p53
...anation for the oncogenesis potential of the virus oncoprotein LTag. LTag induces the conformational change of p53 protein through physical interactions. By doing so, LTag abolishes the tumor suppressor function of p53, which can lead to genomic instability and tumor formation"....Flipping the angiogenic switch
... Evan (UCSF) and colleagues determined how the Myc oncoprotein drives tumor angiogenesis. The researchers demonstrated that Myc activation in pancreatic cells induces expression of the pro-inflammatory cytokine protein interleukin 1beta (IL-1beta). Rising IL-1beta levels promote the release of sequestered vascul...Other highlights in the November 1 JNCI
...hey were interested in assessing the effects of an oncoprotein called EphA2, the molecule EA5 targets, on cancer cell growth. They found that ovarian cancer cells treated with EA5 had a 90% reduction in EphA2 expression. When used with paclitaxel, EA5 substantially reduced tumor weight and helped mice survive ......eins called oncoproteins. Being able to read trace oncoprotein levels from early-stage tumors would speak volumes...ted samples was analyzed, confirming a decrease in oncoprotein levels. The new nano-fluidic system was also tested on human tumors by measuring the levels of MY...