Tag: "onset" at biology news
Diabetes' link to obesity broken in mice
...e network of factors that lead from obesity to the onset
of diabetes. Based on what they learned, they applied a drug treatment in their new transgenic mice and in a different, previously established mouse line that suffers from obesity and a diabetes-like condition. In both groups, the drug increased insu...
Researchers turn to brainpower to beat dementia
...nes because high intelligence protects against the onset
of dementias such as Alzheimer's disease. "A greater understanding of the role that genes play in regulating intelligence may help in the development of new diagnostic tests and more effective treatments designed to combat cognitive impairment in the...
Columbia scientists identify potential therapy for kidney failure
...cumulated in blood, urine and kidney tissue at the onset
of acute renal failure, making it an effective marker for diagnosing kidney failure in its initial stages. "We found that although Ngal exists in high amounts early in failing kidneys, it is still produced too late to prevent the damage," said Jonat...
Learning to fight an adversary that won't stay down
... drugs so as to avoid overuse and the accompanying onset
of resistance. "There are a relatively small number of antibiotics that have come out that are new, and some of them are very potent and act against most resistant strains," he says. "But the clinicians rightly try to keep these things in reserve for...
21st Century model of healthcare focuses on the family before and after genetic testing
...o shift from a focus on intervention after disease onset
to more predictive and preventive approaches befor...ive treatment interventions exist to alter disease onset
and/or progression. This model is published in the current issue of Family Process. Media wishing t...
Growth in the sea comes down to a struggle for iron
...t global climate, perhaps even contributing to the onset
of ice ages. Martin died in 1993 just as tests of his ideas were getting underway, but scientists have embarked on a series of experiments in three major areas of the world's oceans. "The three areas are the Southern Ocean around Antarctica, the equ...
UCI researchers identify trigger for onset of Alzheimer's, aiding search for new therapies
...ed a trigger at the molecular level that marks the onset
of memory decline in mice genetically engineered t...accumulation within neurons is the trigger for the onset
of memory decline in Alzheimer's. "This finding has important and useful implications for the pharm...
JCI table of contents April 1, 2005
...sease Major information on MODY mutation Mature onset
diabetes of the young (MODY) is an inherited form of diabetes that can result from mutations in many different genes, including HNF-4alpha. HNF-4alpha is expressed in multiple tissues involved in glucose regulation and diabetes, but it was unknown i...
Important discovery about second most fatal cancer
...athological and molecular features: Early age at onset
More common in females More common in right side of colon Little evidence of tumour immunity Frequent mutation of an oncogene called BRAF (also mutated in cancer of thyroid, ovary, and melanoma) Frequent DNA methylation (chemical change which in...
Enriched environment delays onset of Alzheimer's in mice
...ecting activity, exercise and education with later onset
of Alzheimer's, but it has never been clear which came first," said study-author Sangram Sisodia, Ph.D., professor of neurobiology, pharmacology and physiology at the University of Chicago. "Did the active lifestyle delay disease, or was there somet...
Silence the gene, save the cell: RNA interference as promising therapy for ALS
...l sclerosis (ALS), substantially delaying both the onset
and the progression rate of the fatal motor neuron... neurons and neighboring glial cells, and both the onset
and the rate of progression of the disease in the treated mice were substantially reduced. In additi...
Scottish scientists win 800,000 to boost research into fighting killer viruses
... cancer could provide strategies to understand the onset
and progression of human lung cancer, the leading cause of deaths in cancer patients....
Pall prion removal technology presented to FDA blood products advisory committee
...the incubation period from time of exposure to the onset
of symptoms; the number of people potentially harboring vCJD who are asymptomatic; the relationship to other neurodegenerative diseases including Alzheimer's Disease; and whether other prion diseases, such as CWD found in elk and deer across the U.S....
Chemists identify key gene in development of type 1 diabetes
...the destruction of the pancreas and the subsequent onset
of type 1 diabetes. The disease is much less common than type 2 diabetes, formerly known as adult onset
or non-insulin-dependent diabetes, which is often associated with obesity. "We've shown that the MIF...
Wolves alleviate impact of climate change on food supply, finds new UC Berkeley study
...imate over the decades. They found that while the onset
of winter did not change significantly over the decades, snow depths did decline significantly in late winter, particularly after February. At the same time, the number of days where maximum temperatures reached above freezing increased significantly...
Study supports use of aspirin in treating pregnancy disorder
...gement of this risk in both groups may prevent the onset
of long-term heart disease. In the current study, the research team created a model that mimics low-dose aspirin therapy in mice. They found that the uterine and ovarian environments were altered only slightly, and the mice experienced normal inducti...
Joslin Diabetes Center scientists find genetic defects
...ulin-producing beta cells." This first step in the onset
of type 1 diabetes is called insulitis. Later in life, within weeks or even years, full-blown type 1 diabetes emerges. An estimated 1 million people in the United States have type 1 diabetes. Their pancreatic beta cells can no longer make insulin. W...
Regular exercise helps protect muscles in elderly from soreness, injury
...a day or two after such exertion is called delayed onset
muscle soreness, or DOMS. "The way to get rid of this kind of pain is to stay physically active," Devor said. "It's ironic, but muscles are most often injured during exercise. But muscles get stronger by repairing this damage." The current study buil...
UT Southwestern researchers uncover gene variant that appears to predict type 2 diabetes
...llow lifestyle changes that could help prevent the onset
of diabetes," said Dr. Nicola Abate, associate pro...type 2 diabetes were required to have had diabetes onset
before age 60. All subjects were evaluated for diabetes and family history of diabetes, as well as o...
As the protein folds: The tail of the gene tells the tale of Machado-Joseph disease
...ger repeat expansion being associated with earlier onset
and more severe disease. Its symptoms, uncoordinated motor control, worsen with time. To study just how the ataxin-3 protein relates to disease, Bonini and her colleagues worked in a simple model organism, the fruit fly, engineering flies to expres...
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