Tag: "onset" at biology news

Yerkes to develop first transgenic nonhuman primate model for inherited neurodegenerative diseases

...ics at Emory, and his research team will study the onset and progression of Huntington's disease, a genetic, neurodegenerative disorder that causes uncontrolled movements, loss of mental processing capabilities and emotional disturbance, and compare the neurological changes that take place in the transgeni...

Virginia Tech engineer investigates enzyme link to neurological disease

... their inhibition could reduce symptoms, delay the onset of agglomeration, and maintain viable neural cell health extending the quality of life for those afflicted," hypothesizes Brian Love, a professor of materials science and engineering (MSE) at Virginia Tech. Love, who focuses his research on tissue an...

Dangerous tricksters: Some bacterie use immune cells to reproduce

...ofessor Haas comments. Within a few days after the onset of the infection, the macrophages die of the infection, they disintegrate and release the multiplied pathogens. The Bonn cell biologists have demonstrated in the past that this cell death is 'necrotic'. This means that cell components escape, attract...

High doses of vitamin E boost rat survival rate 40%; brain function, neuromuscular gains

... lifespan "is properly described as a delay in the onset of the almost linear decay in mice survival." The mice used in the experiment, the CD-1/UCadiz, are a senescence accelerated strain with a median lifespan of 60-70 weeks and maximal lifespan of 100-120 weeks. Vitamin E supplementation of the test gr...

Methane gyrations last 2,000 years show human influnece on atmosphere

...lture, livestock and natural sources, up until the onset of the Industrial Revolution in the late 1700s, he said. For the first time, researchers were able to separate "pyrogenic" and anaerobic methane sources using a stable-isotope analysis of the ice cores, said James White of CU-Boulder's Institute of ...

Immune system has evolved to prevent autoimmune disease

...ist, but that the length of the infection prior to onset of autoimmune disease is highly variable. "People...nt correlation in time, but a long distribution of onset times would lead to weaker statistical correlations, particularly in those cases where the infection...

Adolescents and young adults with alcohol-use disorders have a smaller prefrontal cortex

...of adolescents and young adults with an adolescent onset AUD is an inherent vulnerability for delayed prefrontal cortex maturation that enhances the risk for poorer executive cognitive functioning and adolescent substance-use disorders." "In addition," said Tapert, "we need to figure out the role of the ot...

Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

...luble protein clumps in the brain, can precede the onset of dementia by many years. These plaques are formed when enzymes cleave the amyloid precursor protein (APP) releasing the toxic beta amyloid fragments that clump together to form the sticky plaques. One of the enzymes doing the cleaving is called bet...

JCI table of contents October 1, 2005

...ne disease. TITLE: Cathepsin L is essential for onset of autoimmune diabetes in NOD mice AUTHOR CONTACT: Hidde Ploegh Harvard Medical School, Boston, MA USA Phone: 617 432 4776; Fax: 617 432 4775; E-mail: ploegh@hms.harvard.edu View the PDF of this article at: https://www.the-jci.org/article.php...

Study points to molecular origin of neurodegenerative disorders, including Huntington's disease

...protein above a certain threshold, the earlier the onset of disease and the more severe the symptoms. This result suggests that abnormally long glutamine tracts render their host protein toxic to nerve cells. "Polyglutamine expansion greater than 35 to 40 repeats is definitely a key player in disease etiol...

Researchers discover gene mutations associate with a chronic pain syndrome

..., and lead to recurring episodes of severe, sudden onset pain in the arms and shoulders as well as weakness, loss of sensation, and muscle wasting. Episodes are often triggered by an infection, an immunization, childbirth, or overworking the arms and shoulders. Nerve inflammation and changes in the blood s...

Secrets to antibody's success against West Nile Virus surprise scientists

...tudies of dengue virus and may be important to the onset of dengue hemorrhagic fever. This theory suggests that dengue and other viruses may have developed tricks that let them reproduce inside macrophages, the immune cells that normally consume and destroy any object that they find covered in antibodies...

Study offers clues to origins of autoimmunity

...mune disease. "There have been reports linking the onset of autoimmunity with a preceding bacterial infection," said Stephen Gauld, Ph.D., lead author and post-doctoral fellow in Dr. Cambier's lab. "We are now conducting experiments to determine the role of pro-inflammatory or bacterial products in the los...

JCI table of contents October 3, 2005

... These results may explain the variation in age of onset and disease severity among TTP patients, which has...ein A5 gene, Q139X, causing a unusual form of late onset familial hyperchylomicronemia, is a rare hereditary enzyme deficiency that results in abnormal break...

PET's imaging power may be best indicator for determining which patients develop Alzheimer's

...r measures that allow the definition of the actual onset of a disease process is apparent. Molecular imaging could play an important role in this context," he stated. "Prediction of Individual Clinical Outcome in Mild Cognitive Impairment (MCI) by Means of Genetic Assessment and 18F-FDG PET" appears in th...

Prozac improves learning and memory in fatal brain disease

... neurons - to normal levels, which helps delay the onset of the inherited fatal disease. People with Hunti...ep in developing effective treatments to delay the onset of symptoms and the progression of Huntington's disease. "Now that we've found fluoxetine improves ...

New advances in Parkinson's research and treatment

...nd environmental and other factors that may impact onset of Parkinson's. Panelists will discuss their work and respond to questions from the audience. WHY: After Alzheimer's disease, Parkinson's is the most common neurodegenerative disorder. There are an estimated 6.3 million people worldwide suffer...

Low blood glucose levels may complicate gastric bypass surgery, study shows

..."In our patients, the fact that the post-operative onset of hyperinsulinemia was not immediate suggests that active expansion of the beta cell mass contributed to the condition," Dr. Patti adds. Other researchers participating in the study included S. Bonner-Weir, Ph.D., of Joslin; E.C. Mun, M.D., J.J. Hol...

How to braid nanoropes

...shold concentration of crosslinkers and the sudden onset of filament bundle formation above this concentration, but systematic experimental studies remain to be done that explore the dependence on the filament number N. Apart from representing important structural elements, filament bundles can also provid...

Multiple sclerosis progression linked to immune-cell substance

...uture we can perhaps use MIF levels to predict the onset of a relapse. But more importantly, perhaps this study will lead to drugs that can halt the course of MS by blocking the action of MIF." MS is an inflammatory, autoimmune disease which primarily affects the brain and spinal cord. Autoimmune diseases...

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