Novel biotoxin being studied for use in opioid withdrawal
...l biotoxin Tetrodotoxin (TTX) for the treatment of opioid withdrawal enrolled their first participants. This...m. It is the first study involving a biotoxin for opioid withdrawal to be done in North America. Use of opioids presents many challenges for the addicts, t...A genetic difference at the opiate receptor gene affects a person's response to alcohol
Previous research has implicated the brain's opioid system in the development of alcohol-use disorders...ers. Previous research has implicated the brain's opioid system in the development of alcohol-use disorders. The mu-opioid receptor, which is encoded by the...Key trigger of opioid withdrawal symptoms found
...y that triggers some of the withdrawal symptoms of opioid drugs like morphine and heroin. They believe that ...s may prove to be useful targets for management of opioid dependence," they wrote. The researchers also wrote that, since GABA is a neurotransmitter that inhi...Ingestion of afterbirth appears to promote maternal behavior in mammals
...nal behavior by mediating the activity of specific opioid activity circuits in the brain. Mark Krista... administering much, much, much smaller amounts of opioid analgesics." POEF is found in amniotic fluid and afterbirth. The new study, whose subjects wi...Opiate cocktail may spare cells from morphine's dark side
...mall doses of two versions of methadone, a related opioid drug, significantly reduced both tolerance and dep...pecialized protein on the surface of cells, the mu opioid peptide receptor, or "MOP" receptor. MOP receptors are also activated by other opioid drugs and by e...Chemical that triggers hibernation may protect muscles
...t HWP works in part through some type of action on opioid receptors. The researchers conclude that "pharmacological preconditioning of skeletal muscle to reduce necrosis [tissue death] associated with hypoxia/reperfusion could provide clinical benefits such as improved recovery time and fewer postsurgical c...Nicotine triggers the same brain reward circuitry as opiates
...rain's opiate receptors, but activates the natural opioid reward pathway in the brain. The researchers, led ...activation. Also, mutant mouse strains lacking the opioid receptor did not show an increase in CREB activity when they received nicotine. The researchers also...PET confirms changes at brain molecular level in bulimia nervosa patients after CB therapy
...22 in Toronto. "This is the first study to examine opioid receptors in bulimia nervosa, and research showed that treatment caused a change in the opioid binding in patients," said Angela S. Guarda, M.D., assistant professor with the department of psychi...Scientists discover the body's marijuana-like compounds are crucial for stress-induced pain relief
... two kinds of stress-induced analgesia mechanisms, opioid and nonopioid (or "opioid independent"). Hohmann and colleagues discovered that the opioid-independent form was produced by release of the brain's own marijuana-like compounds. "We showed that cannabinoid receptors were involved in this remarkable p...Prescription pain patch abuse blamed for increase in deaths
...le dying from an overdose of the drug fentanyl, an opioid 100 times more potent than morphine, rises. Addicts are misusing a clear patch that transfers a controlled dose of fentanyl through the skin into the bloodstream over the course of a few days, UF experts say. The adhesive patch is typically prescribe...Brain's opioid receptorsor endorphin systemmay hold key to treatment possibilities for bulimia
RESTON, Va.-- The role of the brain's opioid receptor system--or endorphin system--may hold the... Journal of Nuclear Medicine . "Involvement of the opioid system may explain the addictive quality of this behavioral disorder," said Angela Guarda, M.D., ass...Thinking the pain away? Study shows the brain's painkillers may cause 'placebo effect'
...hine, methadone and anesthetics also act on the mu opioid receptor system to reduce pain. Because the endor...ging of the participants' endogenous pain-reducing opioid systems sheds new light on why the placebo effect occurs. The imaging method used in the study invol...Acupuncture versus acid reflux: 40% cut in sphincter relaxations brings hope for relief
...onjecture, though some studies have suggested that opioid receptors may be involved. So after the initial findings, the Holloway team essentially repeated the experiment to test this hypothesis by seeing if the receptor antagonist naloxone would block the acupoint effect. The results were negative, "but due...Researchers find how one genetic variation may leave some people vulnerable to addiction
... University. These particular receptors, called mu opioid receptors, serve as a molecular docking station fo...18G is a variation in what researchers call the mu opioid receptor gene.) While Sadee and his team didn't look at the interaction between narcotics and the mu...Hepatitis C complicated by morphine withdrawal
...e withdrawal, which is a common recurring event in opioid users. Chuan-Qing Wang and colleagues examined t...sessed the effects of using naloxone, to block the opioid receptors, in conjunction with drug removal, i.e. precipitated morphine withdrawal (PW). To measure...Large family study pinpoints genetic linkage in drug addiction
... families, most with at least two individuals with opioid dependence. They then searched genetic signposts t...lowed the team to identify where genes influencing opioid dependence are located. Gelernter said the researchers found evidence of gene linkage for opioid dep...Brain differences could explain why males and females experience pain relief differently
...ter degree in males than in females. Morphine an opioid drug or narcotic - reduced the response of this ci...dicine and the American Pain Society indicate that opioid drugs or "narcotics", such as morphine, are essential in the management of chronic pain. However, t...News tips from The Journal of Neuroscience
... attributable to estrogen regulation of endogenous opioid neurotransmission. Women subjects were treated for...-treated subjects displayed regional activation of opioid neurotransmission as measured by reduced in vivo receptor availability. In a test of recall, estro...'Thirst for knowledge' may be opium craving
...e greater the neural activity in the areas rich in opioid receptors, the greater the pleasure. In a series of functional magnetic resonance imaging trials with human volunteers exposed to a wide variety of images, Biederman's research group found that strongly preferred images prompted the greatest fMRI act...Under certain genetic circumstances, naltrexone may increase the urge to drink
Naltrexone (NTX) is an opioid antagonist medication used for the treatment of alcoholism. NTX may be more effective among individuals with a family history of alcoholism, suggesting a genetic influence on treatment response. Findings indicate that Asp carriers of the OPRM1 gene w...