Tag: "orchestrate" at biology news

Story ideas from the Journal of Biological Chemistry

...Researchers provide new details about how proteins orchestrate cell division. Cells can divide only when certain key proteins are activated and others inhibited. A protein called NIPA and a set of two proteins called cyclin B1 and Cdk1 are some of these key proteins. Until now, scientists had shown that the c...

Cholesterol could be key to treating fetal alcohol syndrome

...mall amounts, blocks the ability of cholesterol to orchestrate the complex series of events involved in regulating cell fates and organ development in the embryo. Encouragingly, the researchers also found that giving supplemental cholesterol to zebrafish embryos exposed to alcohol restored normal development. ...

Major gene study uncovers secrets of leukemia

...ncode proteins called transcription factors, which orchestrate the expression of a large number of other genes involved in B cell development. Together these genes coordinate the complex changes needed to induce progenitor cells to differentiate into B lymphocytes. In ALL, the leukemic cells fail to differentiat...

EO Lawrence Award goes to 8 scientists and engineers

...that regulate the activation of T lymphocytes that orchestrate the immune response. His ground-breaking theoretical work has had widespread impact on experimental cellular and molecular immunology. My Hang V. Huynh, a chemist, is the pioneer for the groundbreaking discovery of Green Primary Explosives to repl...

Complex channels

...na behind the way proteins organize themselves and orchestrate biological processes may allow scientists to design better or more efficient drugs....

There goes the neighborhood: Vascular niche nurtures brain tumor stem cells

...t small blood vessels associated with brain tumors orchestrate a distinct microenvironment that is critical for maintaining CSCs. Importantly, antiangiogenic drugs that disrupt this microenvironment reduce the CSC population and arrest tumor growth. Dr. Richard J. Gilbertson and colleagues from the St. Jude Chi...

JDRF forms partnership with MacroGenics

...ock the function of CD3 cells; immune T cells that orchestrate the destruction of islets. The antibodies prevent "activation" of the T cells after they have identified their target, disarming them once they are poised to attack. Teplizumab is a humanized monoclonal antibody that binds to an epitope of the CD3-...

NIH Nanomedicine Center draws on NYU School of Medicine expertise

... about which little is known. The proteins that orchestrate the DNA loop formation are recombination-activating gene proteins called RAG1 and RAG2. In their controlled experiment on DNA repair, the scientists plan to watch these proteins, and the subsequent repair of the DNA breaks by nonhomologous DNA end-jo...

Potential new therapeutic target for asthma, allergies and cancer

...onses. Therefore, S1P secreted from mast cells can orchestrate many allergic responses, including asthma, she said....

Three UCSF faculty elected to Institute of Medicine

... His research focuses on the regulatory genes that orchestrate development of the forebrain. In the mammalian embryo, the forebrain is the portion of the neural tube where primitive cells are organized to form the cerebral cortex, the basal ganglia and other components of the adult brain -- the structures of the...

Researchers develop flood-tolerant California rice

...t in the submergence tolerant line the rice plants orchestrate a number of cellular responses to submergence that are controlled by specific genes present in the submergence gene cluster. The researchers report that this cluster, which originated in the Indian rice and was bred into the California rice, is respo...

New research points toward mechanism of age-onset toxicity of Alzheimer's protein

...Two proteins controlled by insulin/IGF-1 signaling orchestrate detoxification--HSF-1, which takes care of aggregate break-down, and DAF-16, which mediates formation of safer, super-sized aggregates as debris accumulates. "We assumed that DAF-16 and HSF-1 would do the same job, but they don't. This is extremely e...

Sunnybrook researchers identify which sets of molecules are required to induce T cells

...old exciting clinical promise for their ability to orchestrate immunity to a broad range of foreign molecules; experiments in mice have shown that gamma-delta T cell injections can eliminate cancerous tumours, although much work remains to translate this research into viable clinical therapy. Ziga-Pflcker was ...

Researchers find new clues to biochemistry of 'anti-aging'

...onger life span and healthier aging in humans, may orchestrate the activity of other enzymes involved in metabolic processes in the body. Published in the June 19-23 issue of Proceedings of the National Academy of Sciences, the study is the first to show that sirtuins directly control specific metabolic enzymes...

Cells use mix-and-match approach to tailor regulation of genes

...h more revealing and detailed picture of how cells orchestrate gene regulation to cope with different environments," said Ideker. "We're far from understanding the full picture of gene regulation in a cell, but this new information should give scientists who are interested in blocking transcription factors a pow...

DARPA grant supports research toward realizing tissue regeneration

...cluding humans. Specifically, they will attempt to orchestrate the formation of a blastema in response to an injury at the site where nature would normally direct the accumulation of scar tissue. "If we succeed in being able to produce a regenerative response in a nonregenerative mammal, we will have overcome a...

Celgene founder Sol J. Barer to receive 2006 Winthrop-Sears Award

...group within Celanese Corporation prior to helping orchestrate its spin off as a stand-alone company. Among numerous other pivotal roles, he established and implemented Celgene's overall business strategy and led the development of its technology platforms (oncology and immunology). Earlier in his career, in add...

Insects that produce males from unfertilized eggs reveal a surprising cellular feat

...anisms we haven't even imagined." Centrosomes help orchestrate cell division, building an apparatus of microtubules called the mitotic spindle, which pulls apart the duplicated chromosomes so that each of the two daughter cells gets a complete set of chromosomes. The centrosome contains about a hundred different...

Researchers provide study of early heart development and underlying cause of congenital heart defects

...e underlying molecular and genetic mechanisms that orchestrate heart development," said Rolf Bodmer, Ph.D., Professor at the Burnham Institute for Medical Research and corresponding author in the study. "These findings provide understanding of early controls in heart development, and we are eager to conduct fur...

Study sheds light on signaling mechanism in stem cells, cancer

...nated a key step in a signaling pathway that helps orchestrate embryonic development. The finding, they say, could lead to insights into the development of stem cells, as well as birth defects and cancers, and thus fuel therapeutic strategies. The study, reported in Nature (Oct. 13, 2005), focuses on the Hedgeho...

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(Date:11/5/2014)... Rio de Janeiro, Brazil -Individuals show great diversity in ... importantly, males and females greatly differ in their perceptual ... kinds of smell tests. , Sex differences ... social behaviors and may be connected to one,s perception ... and emotions. Thus, women,s olfactory superiority has been suggested ...
(Date:11/4/2014)... examining only marketing directed at children on the ... found that the majority of black, middle-income and ... tactics. , Authored by Arizona State University researcher ... the first to examine the use of child-directed ... food restaurants and its relationship to demographics. It ...
(Date:11/3/2014)... University of Colorado Cancer Center study published ... of Sciences describes the activity of a recently ... 37 or IL-37. It has been known to limit ... the adaptive immune system: IL-37 inhibits the ability of ... , "Knowing this mechanism that underlies IL-37,s effect on ...
Breaking Biology News(10 mins):The female nose always knows: Do women have more olfactory neurons? 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3PNAS: From HIV to cancer, IL-37 regulates immune system 2
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