Successful transplantation from pig embryos to mice
...oblems. Unfortunately, there are not nearly enough organ donors available for transplantation. Insulin-prod...Reisner and his team had shown that each embryonic organ has its own 'time window' during which the chances for successful transplantation are optimal. Prior...New stem-cell findings can help the body to cure itself
...n. Too few cells, on the other hand, can result in organ degeneration. It is therefore crucial that exactly the right number of cells are produced. As many serious disorders cause a reduction in the production of new cells, scientists are keen to develop drugs that stimulate the process, which in turn coul...UCSD researchers develop 'smart petri dish'
... headed the research team. "Since the liver is the organ that cleans up the blood, liver cells are particularly susceptible when a toxin is introduced to the body. Pharmaceutical companies want to know early on the effect a drug has on the liver. But it's very expensive to screen every potential candidate ...Speeding the search for elusive chromosomal errors
...ths. Frequently the gene aberrations harm multiple organ systems. For example, patients with chromosome 22q11.2 deletion syndrome may have heart defects, impaired immunity and developmental delay. Deletions of several genes in Prader-Willi syndrome may cause obesity and mental retardation. To seek out mini...Patients to benefit from novel technology revolutionizing high-speed molecular imaging
...ng detector design capable of dwelling more on the organ of interest. This, together with radiation collection angles larger than in existing technology, constitutes a radical departure from the conventional Anger camera," he detailed. Besides providing improved statistics leading to better image quality a...Alexander Gottschalk receives 2006 Benedict Cassen Prize for research in nuclear medicine
...st instrument capable of making an image of a body organ in a patient--was seminal to the development of clinical nuclear medicine. Gottschalk is one of eight individuals who have been presented this prestigious $25,000 award by the ERF since 1994....Patient's generosity after death leads to possible clues for lung disease
...retrieve tissue from multiple locations within the organ and see how they compare." Collagen- and connective tissue-making cells in lungs affected by IPF begin to look and act more like muscle cells, he continued. These cells, called fibroblasts, in essence become supercharged, secreting more connective ti...... often given to suppress the immune system before organ transplants tended to lose bone mass. Those pati...to promote bone formation without disturbing other organ systems that use this same pathway. "The results were dramatic, yet the molecular alteration is very...JCI table of contents, June 1, 2006
...east cancer spread The spread of a tumor from one organ to another is the major cause of morbidity from ca...helial cells in breast tissue to spread to another organ is dependent on a signaling pathway that involves platelet-derived growth factor (PDGF) and its rece...Electric fish in Africa could be example of evolution in action
...ds -- emit weak electric fields from a batterylike organ in their tails to sense their surroundings and communicate with other fish. Each species of mormyrid gives off a single characteristic electric impulse resulting in the flash of signals, indicating, for example, aggression, courtship and fear. While ...Two UH grads a step closer to realizing 'The American Dream'
...ystem allows for new experimentation in artificial organ control that aims to maintain important physiological parameters and makes experiments more flexible, easier, more predictable and less expensive. In 2005, his model of the circulatory system earned him a professional engineer's fellowship from the ...New study finds key role for VEGF in onset of sepsis
... responses throughout the body. A leading cause of organ failure and intensive care unit (ICU) hospitalizations, severe sepsis accounts for 200,000 deaths each year and poses a particular danger in hospital settings, where patients are more likely to come in contact with antibiotic-resistant pathogens, and...JCI table of contents, May 18, 2006
...g and everything in its place During development, organ formation is controlled by a strictly coordinated ...isms do not function properly and can result in an organ of other structure being positioned abnormally within the body (a condition known as ectopia). In a ...New compound reduces stroke damage
...tered to patients receiving transplants to prevent organ rejection. Dervatives of the drug are also commonly used in the treatment of autoimmune diseases. FK506 inhibits T-cell activation by binding to members of the FK506-binding protein (FKBP) family. Interestingly, FK506, and several molecules with simi...Fox Chase study sheds light on cancer susceptibility and disease involving bone-marrow failure
...lled dyskeratosis congenita. It involves multiple organ systems and includes premature aging and increased susceptibility to cancer. The disease results from a gene mutation, Dkc1, that affects ribosome function. Dyskeratosis congenita involves abnormal bone marrow leading to anemia, immune deficiency ...UCSF Institute for Regeneration Medicine receives gift from Dolbys
...he molecular and cellular mechanisms of tissue and organ development, and the cell physiological basis of many degenerative diseases. "The convergence of these advances in developmental biology and stem cell research has created a new paradigm in clinical medicine, where treatments for traumatic and degen...Whale bubble nets, saxophone sounds, ultrasonic laser
...nce indicates the sacculus, a primordial inner-ear organ found in all vertebrates including humans, plays a role in hearing and communication. This means that hearing in humans and many other species involves more than the cochlea, the inner-ear structure traditionally associated with auditory function. C...Copying nature could save us energy, study shows
...r structural health monitoring) and the egg-laying organ of a wood-wasp (for a new type of steerable endoscope). "Evolution has sculpted animals, insects and plants to produce incredibly efficient machines that carry out a range of impressive engineering feats," said Professor Vincent, Director of the Cent...Imbalance may trigger advance from fatty liver to liver failure
...member of the B family of vitamins and is found in organ meats, wheat germ, leafy vegetables, and egg yolks. The team earlier found that mice lacking PEMT, when fed a diet deficient for choline, developed liver failure. The researchers now demonstrate that the liver failure observed in the choline-deficie......ds stem cells with bone marrow cells to regenerate organ tissue. Scientists in the OHSU School of Medicine found that transplanted cells derived from adult bone marrow can fuse with intestinal stem cells of both normal and diseased tissue comprising the cellular lining of intestinal walls, known as the epi...