NIH skate choice follows MDI Bio Lab white paper
...esponsible for development of the skate as a model organism for human disease. The result is that we have a high concentration of information and expertise on elasmobranch organisms and are well positioned to support this important initiative." Data from the skate sequencing project will be integrated into ...Yeast finding links processes in heart disease and cancer
... researchers discovered that a gene that helps the organism make cholesterol also helps it survive when oxygen...d on, what it does and how it's shut off -- if the organism has an equivalent process. Turning first to databases of the entire genetic sequences of various yea...Urine helps infectious yeast stick
...iacin that these genes are turned on, allowing the organism to stick to host cells." The new study builds on t... The environment's effect on these genes helps the organism recognize a good place to colonize, says Cormack. In the new work, graduate student Renee Domergue s...Unlocking genetic mysteries focus of UH symposium
...w it changes over time and how genes move from one organism to another, scientists can find solutions to problems such as bacterial resistance to antibiotics a common concern in hospitals where bacteria share close space with the drugs used to destroy them and species extinction and other issues of conserva...Chemical compounds present in diet increase risk of colon cancer
...ute of entrance to the body. Once in the body, the organism has difficulty metabolising them and they usually become stored in the adipose tissue. That means that their half life within the body is on the order of years or even decades. Organochlorines are excreted from the body by the intestinal route, eith......n kinase A (PKA) signaling pathway occurs when the organism encounters starvation. The pathway enables the single cells to combine into a multi-cell organism. "We pretended we did not know the order of genes in the pathway," said Shaulsky. "We were able to reconstruct the pathway from the microarray data. Thi...A new way to share models of biological systems
... interconnected in complex ways to ensure that the organism responds appropriately to its environment. One of the best ways of ensuring that we really understand how these processes fit together is to build computer models of them. If a computer model behaves differently than the real organism, we know that w...Joining hands to solve a DNA replication problem
... step in DNA processing in mammalian cells. Every organism has an ssDNA-binding protein for DNA replication and repair pathways. In eukaryotes or organisms whose cells have a nucleus, it is called replication protein A (RPA). One of the common functions of RPA in DNA processing pathways is facilitating "hand...Study reveals candidate targets for anti-retroviral therapeutics
...ieve that these simple elements in a single-celled organism are a good model for understanding how retroviruses such as HIV interact with their hosts. Yeast has previously been used as a model to help scientists understand how cancer cells replicate out of control. The Sandmeyer laboratory, which has experti...Extreme life discovery in Yellowstone bodes well for astrobiologists, says Colorado U. study
...rganisms by reading gene sequences. "Each kind of organism has a unique sequence, which is used to map its position in the tree of life," said Walker. "It's a family tree of sorts that describes the genetic relationship between all known organisms." Walker discovered the new microbe community in 2003 after...Same-sex mating discovered in a toxic fungus
... sexual reproductive potential be maintained in an organism with a largely unisexual population structure?" Heitman asked. "The fruiting of alpha strains provided a clue." In their laboratory experiments, the researchers found that, rather than being an asexual process, the hallmarks of mating occur during fr...Buying time through 'hibernation on demand'
...n turn, is what the researchers believe causes the organism to shut down metabolically and enter a hibernation-like state. In each case, upon re-exposure to normal room air, the organisms quickly regained normal function and metabolic activity with no long-term negative effects. If Roth and colleagues are abl...Researchers identify protein crucial for survival of Lyme-disease bacterium
...ld give researchers additional clues as to how the organism has evolved to survive in ticks and why it has cho...orgard said, is the other side of the coin. "This organism has to live half of its life cycle in a tick," he said. "There must be subsets of genes important to...Can our genes tell the story of our divergence?
...ber and decrease cell death), and the need for the organism to avoid cancer. Future studies will have to determine whether these explanations - of an evolutionary arms race - prove plausible. We're a long way from understanding why we're so different from our closest primate cousins, but this study provide...Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration
...o genetic manipulation. It is an extremely simple organism with little redundancy in its genes, meaning it has fewer genes to carry out specific functions. This makes it easier to identify a gene's function by silencing it and will help how researchers target their efforts on equivalent genes in mice or zebr...Aeras and UCLA announce license deal for new TB vaccine
...overexpresses the major protein secreted by the TB organism and uses the current TB vaccine, Bacille Calmette-Guerin, or BCG, as a delivery vehicle. "Tuberculosis ranks among the world's most important diseases; yet it has received relatively little attention in the highly industrialized nations," said Dr. H...Genome of social amoeba shows its importance as research model
...coideum reveals new information about this unusual organism that makes it even more useful as a model for rese...e. The report outlines the unusual features of the organism itself. Kuspa said the sequencing effort has, over the past five years, clarified the place this un...VaxGen and EndoBiologics form collaboration to pursue early stage research for meningitis B vaccine
...opment." EndoBiologics' production method uses the organism Dictyostelium discoideum as a biological mechanism for producing a potential vaccine antigen from lipooligosaccharide (LOS). LOS is a carbohydrate structure on the surface of the Meningitis B bacteria. Dictyostelium uses the Meningitis B bacterium a...Researchers develop new method for facile identification of proteins in bacterial cells
...ntal cleanup. The researchers used a dioxin-eating organism to demonstrate the capabilities of their methodology, which they described in an article published in the May 2005 edition of Applied and Environmental Microbiology. PMF typically involves elaborate sample preparation. A protein mixture is spread acr......nt way to study those human diseases with a simple organism in their laboratories. For evolutionary biologists...imals and plants. Dictyostelium is used as a model organism for studying cell polarity, how cells move and the differentiation of tissues. It also exhibits many...