Cracking open the black box of autoimmune disease
...his happens, the frontline T cells damage multiple organs and cause symptoms of type 1 diabetes and Crohn's disease. However, until now, scientists have barely understood how Foxp3 controls regulatory T cells because they knew almost nothing about the actual genes under Foxp3's purview. Researchers in Ri...Getting to the bottom of memory
...pathway through which it affects memory. Our sense organs inform our brain about what happens around us and brain cells communicate this information between each other using electrical signals. These signals become stronger the more often a cell experiences the same stimulus allowing it to distinguish famil...Scientists uncover potential key to brain blood-flow disorders
...od flow to occur in the brain, as well as in other organs and tissues. With this knowledge, lead study author Mark Nelson, Ph.D., professor and chair of pharmacology at the University of Vermont, set out to determine whether the diameter of cerebral blood vessels in the brain could be modulated under physio...Complexity constrains evolution of human brain genes
...slowdown in genetic evolution in the more advanced organs makes sense," he said, "only when one takes a systems perspective."...Abnormal proteins linked to schizophrenia found in body tissue
...ught to detect similarly altered proteins in other organs and tissues of individuals living with the disease. After looking at thousands of proteins, they found that people with schizophrenia had 14 liver proteins and eight red blood cell proteins that were significantly altered compared to individuals who ...U of MN researchers find novel genes critical in organ development
..., differentiate and migrate to properly form vital organs in the correct places during development. The re...on give us a new level of resolution for how these organs develop," said Stephen Ekker, Ph.D., associate professor of Genetics, Cell Biology and Development a...Linchpin discovered in insulin metabolism
...nce of reactions it ensures that muscles and other organs absorb blood sugar. What is more, however, the cascade of insulin signals also determines size and number of the body cells during growth. Apparently, 'Titch' plays a key role in this shower of signals. 'The fruit fly larvae increase their weight 20...For crickets, parasitic flies can stop the music
...burrow into the insects, then feed on nonessential organs within the cricket while they grow. After they emerge from the dying cricket, they pupate and metamorphose into mature flies. Brockmann and co-author Manuel Vlez, a former UF student who earned his doctorate in 2004, hypothesized that the presence ...Nano-devices hold promise for early-stage cancer detection
...cation system for non-invasive screening in target organs systems such as the breast, pancreas and gastrointestinal tract and the relaying of information to an external receiver; developing ingestible and insertable non-invasive imagers for routine screening of pancreatic and gastrointestinal tumors; sens...Phylonix awarded National Science Foundation Phase II SBIR for zebrafish screening
...c effects of chemicals on the development of human organs and tissues using a panel of assays performed in zebrafish. "This award validates the importance of zebrafish as a predictive model for assessing toxic effects of environmental contaminants on mammalian development," commented Patricia McGrath, Phy...T-beta-RIII joins the fight against breast cancer
...vade the breast tissue and to metastasize to other organs than tumor cells not engineered to express this protein. Further analysis revealed that the mechanism behind these protective effects of T-beta-RIII was likely to be T-beta-RIII cleavage at the cell membrane, which releases soluble T-beta-RIII that b...JCI table of contents: December 7, 2006
...vade the breast tissue and to metastasize to other organs than tumor cells not engineered to express this protein. Further analysis revealed that the mechanism behind these protective effects of T-beta-RIII was likely to be T-beta-RIII cleavage at the cell membrane, which releases soluble T-beta-RIII that b...Penn researchers discover initial steps in the development of taste
...evelopment in humans. Taste buds are the sensory organs that transmit chemical stimuli from food and other sources to nerve cells, which convey these signals to the taste centers in the brain. Taste buds sit in the small bumps in the surface and sides of the tongue called papillae. The signaling pathwa...Newts which regrow their hearts
...te to new cell therapies for patients with damaged organs (Journal of Cell Science, 2006). The red-spotted newt, Notophthalmus viridescens, is a favourite animal of the researchers working with Thomas Braun in Nauheim. This amphibian comes from the wetlands of North America, but it also feels quite at hom...Research yields new insights into the cause of diabetes
...trains of mice that are PERK-deficient in specific organs or tissues was vital to our research," says Cavener. "These mice allowed us to discover exactly how PERK participates in the development and growth of the beta cells in the pancreas that secrete insulin. Using genetics in this way lets the organism...... with a single X chromosome (X0). The reproductive organs contain about half of the cells in an adult worm, and the process of meiosis can be observed at every stage, as chromosomes first come together during the pairing process, then later separate during meiotic division. One result of failed pairing of...Living view in animals shows how cells decide to make proteins
...t the IIIb exon -- and if so, in which tissues and organs -- or whether other types of silencers or helper p...er, different cell types within the brain or other organs can exhibit different splicing decisions, Garcia-Blanco said. For example, neurons reside next to gl...ACS News Service Weekly PressPac -- Nov. 22, 2006
...accumulate in the liver, heart, pancreas and other organs and eventually cause serious damage. Raymond J. B...s remove only small amounts of iron from sensitive organs like the heart. Treatment sometimes must continue for years to remove enough iron to prevent organ d...Yale Cell Biologist Joel Rosenbaum, to receive Prestigious Wilson Award
... inversus, a condition in which the heart or other organs grow on the wrong side of the bodys midline during embryonic development. Rosenbaums colleague in pediatric cardiology, Associate Professor Martina Brueckner, has shown that the presence of cilia in the embryonic nodal region is directly related to ...