Manipulation of epigenome turns off as many genes as it turns on
...he researchers also tested the effects of knocking out of the cancer cell line either of two genes that e...ok methyl groups onto the DNA, as well as knocking out both genes in the same cell. They compared these methyl-based mechanisms of gene regulation to a chr...Consuming fruits and vegetables lowers risk of developing NHL
...ong the most common childhood cancers, more than 9 out of 10 cases occur in adults....Experimental lupus drug may also work against atherosclerosis
...educes symptoms of systemic lupus in mice may turn out to be effective against hardening of the arteries and thus prevent heart attacks, according to two poster presentations today at the American College of Rheumatology meeting in San Antonio. Nilamadhab Mishra, M.D., of Wake Forest University Baptist M...Dr. Harris receives NIH Javits Neuroscience Investigator Award
...fter induction of long-term potentiation, and find out when the different molecules change, whether the synapses remain enlarged, start to fall off, fall off with LTP or something else." Dr. Cliff Abraham, neuroscientist and chief of the Psychology Department at the University of Otago in Dunedin, Ne...ASPB opposes proposed ban of GMOs in Humboldt county ballot measure M
...fessor at University of California, Davis, pointed out serious flaws with the ballot measure. They noted that jailing of farmers and scientists pursuant to Measure M for use of safe, innovative technologies is unjust, anti-science and harmful to American agriculture. Following is the ASPB letter sent...Gene linked to greater risk of heart disease in type 2 diabetes
... any visible heart disease. The researchers mapped out each person's CD36 gene variations, then compared those results with the presence of known heart disease. Again, there was a strong link: People with that specific variant combination in the CD36 gene were 60 percent more likely to have heart disease...Lag-3 gene dampens immune responses by controlling regulatory T-cell function
...ke to prevent immune system responses from running out of control solves a mystery that has puzzled researchers since the gene was discovered 14 years ago. A report on this discovery, from investigators at St. Jude Children's Research Hospital and The Johns Hopkins Kimmel Cancer Center, is published in t...$2.8 million NIH grant awarded to UH for bionano training
...ce in doing research, as well as helping them find out what areas they excel in and should likely pursue ...sing the basic sciences as a springboard to branch out to more applied science through this grant," Pettitt said. "Training is research in a lab. The tra...Gene-altered mouse is model for rare autoimmune syndrome
DURHAM, N.C. -- By knocking out a single gene in mice, immunologists at Duke Unive... said. Zhuang and his colleagues did not set out to produce a mimic of Sjgren's syndrome in their studies. Rather they were exploring the role of a r...Genetically modified parasite lets researchers probe immune system's memory
...ired for DNA synthesis and can be completely wiped out by the mouse immune system. Researchers found that after the mice had cleared the Leishmania parasite, a type of T cell -- the CD4+ central memory T cell -- still reacted to the parasite in the test tube. Mice who never had Leishmania and were given ...Incentives for US farmers reduce water waste
...d plagued by shortages of water, three facts stand out in an analysis by Cornell University ecologists: Less than 1 percent of water on the planet is fresh water; agriculture in the United States consumes 80 percent of the available fresh water each year; and 60 percent of U.S. water intended for crop ir...Genetic data crunching achieves milestone at Stanford
...tages of development. Researchers use them to nose out the genes associated with such changes. The proble... how various drugs affect the malaria bug, to find out what the immune system attacks in patients with autoimmune diseases and to pinpoint genes involved i...DFG research training groups become increasingly international
...e on Research Training Groups selected 23 projects out of 66 new funding proposals. This is the highest number of funding proposals received over the past eight years. The programme has become increasingly attractive to international groups of applicants. The large number of new proposals from the engine...Babies born after surgery on eggs
...work is impressive, but he has concerns. He points out that we do not understand the consequences of moving mitochondria from one cell type to another. For instance, in eggs and early embryos mitochondria do not replicate, while they do in granulosa cells. More seriously, he says the group should have do...For inferring the biological tree of life, simple is better
...r method, largely abandoned in recent years, turns out to be far more accurate. These surprising findings...matic model of the evolutionary process. "It turns out that the complicated method performs well when reality is simple, but the simpler method is much mor...OHSU study: Bacterial switching mechanism key to survival
...s the carbohydrate glucose, are low. "Bacteria are out there in the real world fighting each other for li...al molecule, glucose is able to pass freely in and out of a bacterium cell's membrane. When glucose is available as the energy source, the cell traps the m...New DNA repair enzyme makes mistakes to save lives of cells
...es in human cells. These specialized enzymes carry out the duplication, proofreading and repair of DNA. DNA is a double-stranded molecule that contains genes necessary for the production of proteins, which in turn determine all aspects of a cell's structure, function and movement. Each strand consists of...Molecule that helps DNA replicate may make good target for cancer therapy
...l division seen in cancerous tumors. The work grew out of a desire to learn the identity of the "tugboat," said Anja Bielinsky, an assistant professor of biochemistry, molecular biology and biophysics, in whose laboratory the work was performed. The first author on the paper is Robin Ricke, a graduate st...Mouse study: 'Critical' Down syndrome region isn't
...netic dose might be modifiable -- if we can figure out the key players." As part of this effort, Olson used a technique to precisely duplicate a defined chromosome segment and applied it to the DSCR section on mouse chromosome 16, the analog of human chromosome 21. She also made a mouse chromosome 16 tha...UF scientist: 'Brain' in a dish acts as autopilot, living computer
... see one extend a process, pull it back, extend it out and it may do that a couple of times, just sampli... a network, DeMarse said. "There's a lot of data out there that will tell you that the computation that's going on here isn't based on just one neuron. T...