New target for HIV/AIDS drugs and vaccine discovered
...or people with diseases and disorders that involve overactive or underactive immune responses. DCs and NK cells play critical roles in the bodys initial defense against infection. DCs are instrumental in identifying foreign invaders to the body and then orchestrating an immune response that ultimately removes t...Hypothyroidism clearly linked to mood swings
...e are 27 million Americans who have underactive or overactive thyroid glands, but more than half remain undiagnosed, according to recent statistics. Hypothyroidism can be treated by doses of thyroid hormone. Once the blood levels of thyroid hormone reach a normal rangecalled euthyroidlethargy and depression o......reat synovial sarcoma. But other genes that are overactive in synovial sarcoma tumors were identified in the new study, and they also may be potential targets for anticancer medicines, he adds. ...MIT: Pulsing light silences overactive neurons
...ctric jolt, acting as a defibrillator to shut down overactive neurons. This new research opens up the possibility of an optical implant that could do the same thing, using light instead of electricity. The Media Lab neuroengineering group plans to start studying such devices in transgenic mice this year. The ...Researchers identify key protein in immune response to malaria and TB
...mother and one from the father. "If you have the overactive type, you are twice as likely to succumb to infect...tivating." The researchers found that having the overactive Mal doubled the risk of disease, with a four times greater risk of severe malaria in some population...New compound prevents alcoholic behavior, relapse in animals by blocking stress response
...o. The new study shows that the CRF system becomes overactive in the long term in animals with a history of alcohol dependence, increasing the risk for relapse. Heilig and his team showed that MTIP blocked the activity of CRF in stressful situations without affecting its activity under ordinary circumstances...Pioneering research into health benefits of beauty treatment
...otulinum toxin into the bladders of women who have overactive bladder disease. The trial, which has received a g...ilence, but the quality of life when you live with overactive bladder is similar to that of a patient on kidney dialysis. Botulinum toxin has been tested already ...Prevalence of overactive bladder is overestimated
According to the International Continence Society, overactive bladder is a symptom-defined condition characteriz...ency and nocturia (night-time urination). The term overactive bladder is appropriate if there is no proven urinary tract infection or other obvious pathology. O...Study reveals molecular basis of botulism toxin's deadly activity
...al palsy and multiple sclerosis that are caused by overactive nerve signaling, which the toxins can reduce. However, for reasons not completely clear, some patients do not respond to current treatments. This could be due to variations in their nerve cells that prevent the toxins from binding. If that is the cas...Seeing a neurotoxin's deadly grip
...aches, involuntary contraction of the eye muscles, overactive bladder syndrome, excessive sweating and spastic disorders associated with injury or disease. The researchers see the potential for even more widespread use. "These toxins could prove the ideal basis for drugs, because they work at extremely low conc...Gene therapy for erectile dysfunction shows promise in clinical trial
...y works on smooth muscle, it is also promising for overactive bladder disease," adds Dr. Melman....Tailored treatments: Promising designer drug provides new insight into cancer biology
... molecules like BCL-2 are abnormally regulated and overactive in many tumors and are thought to promote cancer progression and protect cancer cells from cancer therapies. In normal cells, BH3 proteins bind to and inhibit BCL-2. Therefore, researchers have attempted to design compounds that are similar to these ...Scientists use gene signatures to match cancer and other diseases with potentially effective drugs
...a molecule called HSPH90, which in turn blocks the overactive cell signaling of the androgen receptor in prostate cancer cells that drives their aggressive growth. Dana-Farber researcher Haley Hieronymus, PhD, who used the Connectivity Map to sift through thousands of drugs and compounds, is the paper's lead au...A tNOX-based protocol for early detection of lung cancer in smokers and nonsmokers
...ability to express NOX activity at all times. This overactive form of NOX, known as tNOX for tumor-associated NOX has long been assumed to be vital for the growth of cancer cells, because drugs that inhibit tNOX activity also block tumor cell growth in culture. The researchers compared four different protoco......her blood cells form or not. On the other hand, an overactive Wingless pathway doesn't seem to damage cells that already exist. Thus beta-catenin seems to be a decision-maker, a selector of how information gets routed within the cell, rather than something which maintains the vitality of existing cells. Nerlo...RSRF-funded research links Rett syndrome to mitochondrial gene
...ession of this gene was solely responsible for the overactive mitochondria. And the data said it's likely to be," says Bird. He adds that additional experiments are needed to link the mitochondrial abnormalities to the symptoms found in the mutant mice. The researchers also caution that similar defects need to ...For Stanford scientists, RNAi gene therapy takes two steps forward, one step back
...ces a molecule called an shRNA, which turns off an overactive gene. With key genes shut off, viruses such as hepatitis B, hepatitis C or HIV are unable to multiply and cause disease. However, some reports had suggested that RNAi gene therapy might induce an immune reaction or switch off the wrong gene or genes....Salk scientist Ron Evans wins 2006 Gairdner Award for his discovery of hormone sensors
...Mice that are genetically engineered to produce an overactive version of PPAR delta burn dietary fat at very high rates and have stronger slow-twitch muscle mass. When placed on a rodent-sized treadmill, these genetically engineered "marathon mice" run twice as far as their normal counterparts. Dr. Evans' lab's...JCI table of contents, March 16, 2006
...gan transplantation, which are characterized by an overactive immune response. TITLE: Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen presenting cells and immunological tolerance AUTHOR CONTACT: Bali Pulendran Emory University, Atlanta, Georgia, USA Phone: (404) 727-8945; Fax: ......ppress the immune system, the researchers said. An overactive immune system, for example, can set off the excessive inflammation associated with rheumatoid arthritis and lupus. In addition, some cancers are more likely to grow where inflammation occurs. These ailments might be helped by a drug that curbs inflam...