Leptin: A 'missing link' between obesity and diabetes?
... the journal Nature that showed the s/s mice would overeat and become obese, and have other problems with their neuroendocrine system, but would not lose their ability to reproduce. This was the first time that STAT3 signaling was implicated in obesity. The mice are so-called "knock-in" mice, because the sc...Weight control protein may yield antiobesity drugs
...to maintain normal body weight. Mice lacking SH2-B overeat and become obese, the team found. The animals additionally develop a metabolic syndrome characterized by high blood concentrations of leptin, insulin, and lipids. They also develop fatty livers and high blood sugar, the group reports. "Our findings r...JCI table of contents, March 9, 2006
... diet, which stimulated the animals to voluntarily overeat and gain weight. When the researchers inhibited CPT1A by delivering special molecules called "ribozymes" into the brain of the rats, the animals ate dramatically less. The treatment also improved the blood sugar levels of these animals, who suffered ...Fat rats reveal why short-term overeating can lead to obesity and diabetes
... diet, which stimulated the animals to voluntarily overeat and gain weight. When the researchers inhibited CPT1A by delivering special molecules called "ribozymes" into the brain of the rats, the animals ate dramatically less. The treatment also improved the blood sugar levels of these animals, who suffered ...OHSU research demonstrates possible health risks for children born to overeating mothers
...rch demonstrated that the offspring of mothers who overeat are at risk for liver and pancreas damage. Both of which can contribute to early-onset obesity and diabetes. In addition, significant brain changes can occur in the offspring of some mothers who overeat. These changes take place in the hypothalamus, ......ose people who are lean by nature even though they overeat ? like we all do they will tend to be inefficient in terms of using energy,' says Mike Cawthorne, who heads the Metabolic Research group at Clore. Cawthorne's group has already demonstrated that supplementing infant rats' diets with leptin means ...Hormone that signals fullness also curbs fast food consumption and tendency to binge eat
...y eat, reduce binge eating and resist the drive to overeat even while living in todays environment where access to high-caloric food is abundant every day. While this research is promising, it appears pramlintide will produce only modest weight loss, probably around 8%, before reaching a plateau. Amylin P...Research finds that circadian rhythms dominate all life functions
...with clues for developing ways to treat people who overeat because of impaired leptin signaling. Circadian rhythms are biological rhythms that cycle over a period of about 24 hours and regulate timing for most physiological functions and behaviors such as sleeping, eating and activity.As a checks-and-balance...