New findings help pinpoint autism's genetic roots
...to other nerve cells. This may lead to the sensory overload that people with autism experience, Dr. Parada said. "It would be really exciting if it turned out that we've zeroed in on the anatomical regions where things go wrong in autistic patients, regardless of how the autism occurs," he said, adding that ...If the chemistry is right you might remember this
...ines that could treat conditions where there is an overload of nerve activity, such as during a seizures,' said Dr Phil Robinson leader of the research at the CMRI. The relationship between dynamin and syndapin is also crucial to understanding other processes where there is a high level of brain activity and ...JCI table of contents, June 1, 2006
... cardiac hypertrophy. TITLE: Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction AUTHOR CONTACT: Howard A. Rockman Duke University Medical Center, Durham, North Carolina, USA. Phone: (919) 668-2520; Fax: (919) 668-2524; E-mail: h.rockman@duke.edu . Vi...How plants avoid feeling the burn
...r uncharged state, can readily handle the electron overload from the sun. Their findings have been published in the prestigious journal Proceedings of the National Academy of Sciences (PNAS) under the title"Conductance of a Biomolecular Wire" ( http://www.pnas.org/cgi/content/abstract/0600593103v1 ). "This i...Structure of iron regulatory protein-RNA complex solved
...d metabolism that result in either deficiencies or overload of iron cause a variety of diseases and disorders, including heart disease, arthritis and cancer. The iron regulating protein, called IRP1, has two structural forms, each with important functions within the cell. When serving as one of two regula...Children's Hospital Oakland, Calif.'s new iron regulation discovery
...earchers design medications for patients with iron overload that occurs in hemochromotosis, Sickle Cell Disease and Thalassemia. "Currently, there are medications available that are based on DNA structures such as anti-cancer drugs. Unfortunately, the problem with targeting DNA is that both healthy and can...Putting an old drug to a new use
...used to treat high blood pressure can reverse iron overload in mouse models and has the potential to treat sim...n of toxic radicals leading to tissue damage. Iron overload is the consequence of one of the most common genetic disorders in Europe, hereditary hemochromatosis...Highlighted sessions of ASBMB's 2007 Annual Meeting
...search Hospital, Memphis, Tenn., will discuss iron overload resulting from repeated blood transfusions in sickle cell anemia and how to best monitor and treat this complication. Topic: Enzyme Dynamics Session: The Role of Dynamics in Enzyme Catalysis Time/Location: 11:15 a.m.-11:45 a.m., Room 207B T...Study shows food preparation may play a bigger role in chronic disease than was previously thought
...ve intake of fried, broiled, and grilled foods can overload the bodys natural capacity to remove AGEs," Dr. Vlassara notes, "so they accumulate in our tissues, and take over the bodys own built-in defenses, pushing them toward a state of inflammation. Over time, this can precipitate disease or early aging." ...Keeping the immune system from starting a 'food fight'
... regular diet. In those who regularly consume an overload of nutrients, the flood control protein may become overwhelmed and give out, leading to the chronic, low-grade inflammation characteristic of obesity and other metabolic diseases, the researchers suggest. Treatments designed to reinforce that barrier...JCI table of contents: June 21, 2007
... in heart failure. The authors found that pressure overload of the heart greatly increased cardiac autophagy and heart failure in mice. Furthermore, disruption of the gene encoding the protein Beclin1, a protein known to be required for autophagy, decreased cardiac muscle cell autophagy and diminished harmful...JCI Table of Contents -- July 2, 2007
... anemia while decreased hepcidin levels cause iron overload diseases. In this issue of the JCI, Babitt et al. ...echanistic explanation for the role of HJV in iron overload disease. TITLE: Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron...JCI table of contents -- July 26, 2007
...is able to reverse atherosclerosis and cholesterol overload in mice. The authors began by studying mice lack...sate for the loss of LXR-alpha, reduce cholesterol overload and reduce atherosclerosis. The results of the study suggests that LXR-alpha has an essential role i...Antioxidant overload may underlie a heritable human disease
...e is the key. The researchers show in mice that an overload of natural antioxidants can actually lead the heart to failure. There is plenty of evidence about the damaging effects of oxidative stress, but there is another side to the coin, said Ivor Benjamin of the University of Utah, Salt Lake City. There h...High blood pressure, low energy -- a recipe for heart failure
...sure. The hearts of normal mice took that pressure overload in stride and stayed healthy. Those contrasting ou...s on ERR alpha. "The stress of a cardiac pressure overload asks heart muscle to manufacture more high energy compounds, and without ERR alpha, they can't do it...