New binding target for oncogenic viral protein
... order to do this, they have evolved mechanisms to override normal cellular replication controls. Simian virus 40 (SV40) accomplishes this task by producing the highly oncogenic large T antigen. This protein corrupts the cellular checkpoint mechanisms that guard cell division and the transcription, replicatio...Ancient enzyme guides healthy eating in mammals
...rive to consume foods rich in calories might often override the amino acid gauge that would otherwise promote a balanced diet....Changes in community size affect the outcome of competition
... the study demonstrates that stochastic events may override competitive ability in determining the outcome of competition: inferior competitors are relatively more likely to emerge victorious in ecological communities where the role of chance is increased because communities are small, shrinking, or both. Whe...How HIV disables the cells' call for help
...ead of foreign invaders. If the viruses use FPs to override the cells' call for help, could their actions, which block one type of immune response without killing the cell, be applied to these autoimmune diseases? To check their theory, the research team tested FP on rats suffering from an autoimmune syndrome...Bitter or sweet? The same taste bud can tell the difference
...plan to do that next), Herness thinks that CCK may override NPY during a bitter sensation, while NPY may override CCK during a sweet sensation. Sour and salty the two other dominant tastes seem to work in totally...Erotic images, gore cause temporary 'blindness'
...researchers sought to determine if individuals can override their emotion-induced blindness by focusing more d...he building only--would help the research subjects override their emotion-induced blindness. After running the tests, the researchers discovered that they were ...Muscle of obese 'programmed' to amass fat, genetic study finds
... the researchers. Exercise might more successfully override the aberrant metabolic program in muscle, they suggest, thereby improving the long-term prognosis of those prone to obesity. A diverse team of researchers found that the fat-building enzyme stearoyl-CoA desaturase-1 (SCD-1) is three times more abunda...Brainstem blocks pain to protect key behaviors
... a six-second dose of morphine, allowing hunger to override pain." Mason and colleague Hayley Foo, research associate in NPP, studied adult male rats in containers with a wire mesh floor that enabled them to deliver radiant heat to one hind paw. The heat caused no damage but was annoying enough to make the a...Protein finding could lead to treatment for inflammatory diseases
...said. "Another goal is to design a drug that would override the activity of the protein as a cure for MCV."...AAAS urges US President to sign Embryonic Stem Cell Act
...r votes short of the two-thirds majority needed to override a presidential veto. The President has stated that he would veto the measure, but AAAS called on him to reconsider, noting that "embryonic stem cell research is an extremely promising approach to developing more effective treatments for devastating c...Cell's fight against cancer revealed
...r. "If you have a lot of functional p53, you can override large T antigen," said lead researcher Xiaojiang Chen, professor in molecular and computational biology in the USC College of Letters, Arts and Sciences. Sometimes called the "Guardian of the Genome," a damaged p53 can leave a cell almost defensele...Yale scientists to hold press conference on planetary discoveries, extraterrestrial life
... will help predict the large solar flares that can override power grids and cause massive blackouts. She is also studying the connection between solar changes over decades and drastic changes in climate. "Alien Earths" Exhibition at Yale's Peabody Museum of Natural History: Extraterrestrial Life and Other ...Changes in dietary protein may override inherited skeletal abnormalities
...iet with either high or low amounts of protein may override certain inherited developmental malformations of the skeleton, according to a new report in the December issue of the journal Cell Metabolism, published by Cell Press. Such so-called skeletal dysplasiae include more than 200 disorders of bone growth ...Gene knockouts reveal FoxOs' vital functions in cancer defense, health of stem cells
...ctors, normally function as tumor suppressors that override maverick cells threatening to grow too fast and form tumors. When FoxOs are eliminated, it may allow cancer to develop. The mice lacking FoxO proteins developed two types of cancer thymic lymphoma and hemangiomas, tumors caused by the uncontrolled g...AAAS decries latest stem cell veto
...st short of the two-thirds supermajority needed to override the veto. While Bush signed a separate Executive Order to support other stem cell research, AAAS "strongly believes" that all avenues of stem cell research must be explored, the non-partisan association said a statement. The following is the full t...U-M researchers find family of 'on switches' that cause prostate cancer
...e two genes to fuse together. The fused genes then override the off switch that keeps cells from growing uncontrollably, causing prostate cancer to develop. By testing these gene fusions in mice and in cell cultures, the researchers showed that the fusions are what cause prostate cancer to develop. But its...