New insights into the mechanism for internalization of ubiquitinated cargo
...d the University of Toronto challenge the existing paradigm for how ubiquitin modification of proteins functions in their internalization. In contrast to the prevailing model for the internalization of ubiquitinated proteins, Hawryluk et al. (1) and Barriere et al. (2) demonstrate that high affinity interac...The American obsession with the perfect lawn
...of northern Europe. "By buying into the corporate paradigm and making a fetish of green, weed-free, ultra-trim grass, Americans have alienated themselves from their very own yards," writes Steinberg. "Sadly, the more people invest in the perfect-turf aesthetic, the less they seem to understand about the ecol...Liquid crystals show promise in controlling embryonic stem cells
...is newly devised cell culture system enables a new paradigm in stem cell research," says chemical and biological engineer and MRSEC Director Juan de Pablo. "Ultimately, we hope to use liquid crystalline materials to transmit desired sets of physical and chemical cues to stem cells so as to control their diffe......idea of "Man the Hunter" is the generally accepted paradigm of human evolution, says Sussman, "It developed from a basic Judeo-Christian ideology of man being inherently evil, aggressive and a natural killer. In fact, when you really examine the fossil and living non-human primate evidence, that is just not t...Can science-based resource management work?
... has been controversial. "There's a need for a new paradigm of science in land management," said Thomas W. Swe...Ring Research. "The Valles Caldera has set up this paradigm as an experiment and it's underway." Swetnam will discuss the history and ecology of the Valles Cald...Princeton professor foresees computer science revolution
...ting promises to be the most disruptive scientific paradigm since quantum mechanics. It will transform society in profound way. Isn't computer science really just a stepchild of mathematics? As the recent breakthroughs on Fermat's Last Theorem indicate, the field of mathematics has never been more fertile wit...Tandem transcripts team together
...tic genome, a picture emerges that challenges this paradigm not a picture in which the sequences in the genome have distinct functions, but rather one in which the sequences participate in multiple transcripts, encoding molecules with diverse functionality." Sorek's team systematically identified over 200 ca...FDA approves first medical device using Rutgers biomaterial
...developed at the university. This action signals a paradigm shift in the application of biomaterials from permanent prosthetic replacements toward regenerative medicine, in which materials help the body to repair itself and are then resorbed. The device consists of a surgical mesh coated with a polymer devel...Molecular imaging allows detection of plaques likely to rupture
...ues is a possibility," he said. This supports "the paradigm of prevention rather than treatment of a coronary event," said Petrov. The study "demonstrates that a decrease in apoptosis was associated with behavioral and therapeutic interventions--diet modification and use of statins--known to improve outcomes ...Fertility genes discovered at Rugters
...e processes," Singson said. Fertilization can be a paradigm for gaining insight into how cells interact over the life and development of multicellular organisms because it is one of the most basic of cell-cell interactions. The underlying cell biology is going to be universal with applications even in infecti...Penicillin, amoxicillin: Step aside for strep throat treatment
...sor of Microbiology and Immunology. "The treatment paradigm for treating strep sore throats has been changing slowly, and endorsing the use of cephalosporins as a first-line treatment is something that needs to be seriously considered," Pichichero said. While the newer short-course cephalosporins are only ava...Fish gene sheds light on human skin color variation
... help from model systems like zebrafish is a great paradigm for seeking understanding of other complex diseases such as diabetes or heart disease," Cheng said. The team started with the recently released HapMap a free and publicly accessible database of DNA sequence variation in the human genome. When rese...Research: Snails were overlooked contributors to marsh destruction
...gy, the message is even clearer: The long-standing paradigm that bottom-up forces rule is officially dead." Climate change aside, the study also falls in line with other recent studies highlighting the role of predators or other top-down animals. "This study adds to a growing body of evidence showing strong t...Learning about sex from an elegant worm
...nactive. Says Dernburg, "It used to be taken as a paradigm that both these checkpoint activities were interdependent. Needhi has demonstrated unambiguously that there is a separate checkpoint monitoring synapsis, and that checkpoint requires the PC." One result of the study was to show that the synapsis che...New UW study offers strategy for treatment of fatal nervous system disorder
...ficult. "To eliminate the barrier, we changed the paradigm by transplanting enzyme-deficient cells into the brain and spinal cord of another type of mouse which can provide the enzyme," explains Duncan. The Wisconsin group isolated progenitor cells from the mouse model of Krabbe's disease. Transplanting the...Biodesign Institute awarded $3.2 million to develop vaccine to thwart biothreat
...r F. tularensis but will also assist in defining a paradigm for developing vaccines against other emerging infections," according to Rick Lyons of the University of New Mexico Health Sciences Center. Among the paradigms will be new screening strategies to increase the likelihood of generating an effective an...Sea urchins' unexpectedly diverse 'innate' immune capability points to new research avenue
...pability goes completely against the long-accepted paradigm that the innate immune system which had evolved ov... she said. Next steps that could 'revolutionize' paradigm on invertebrate immune function The paper itself summarizes the findings and implications like this...Study in Royal Society journal on link between creativity and mating success
... regulatory network of Escherichia coli suggests a paradigm for robust regulation of processes in series by Professor M Bhartiya, Mr N Chaudhary, Professor V Venkatesh and Professor J Doyle III The evolutionary process has resulted in complex working designs of organisms to survive in uncertain environments....War on terror meets war on cancer
...-16, and rare hydrogen-2 to common hydrogen-1. The paradigm is that water diffuses so quickly into and out of cells that the water inside a cell is indistinguishable from water outside a cell," Hegg says. The researchers grew E. coli bacteria at body temperature in flasks containing a nutrient-rich liquid cul......ndings of their latest experiments represent a new paradigm for understanding and potentially treating atherosclerosis. They said their finding represents the first time the progression of any chronic disease has been linked to a deficiency in the body's repair machinery. Atherosclerosis is marked by the thic...