Tag: "paradigm" at biology news

OT, VP studied as novel psychiatric drug sources; consider gender-specific drug models

...ase, noting that "this could represent a potential paradigm shift in how we think about the development and marketing of future psychotropic drugs." This is totally consistent with a growing mantra of the drug industry which proposes to develop "the right drug for the right person." Robert H. Ring, Head of M...

Huntington's cure in flies lays groundwork for broader treatment approaches

...ts the growing need to embrace a broader treatment paradigm in the realm of genetic disorders, says Yin. In working with a disorder such as Fragile X Syndrome, for example, conventional therapies might focus all their efforts on repairing the genetic pathways that cause neurons to go awry. Meanwhile, "the def...

Deep-sea jelly uses glowing red lures to catch fish

...esearchers. He explains, "This discovery was a big paradigm shift for us-most jellies were thought to use bioluminescence for defense, but once we saw this, it made us realize that the same thing was happening in other species." Erenna's glowing red lures may also force scientists to take a new look at the r...

Imaging goes 3-D: 'exquisite' PET/CT image captures SNM's 2005 Image of the Year

...intended to be an initial step in developing a new paradigm for reviewing and interpreting positron emission tomography (PET)/computed tomography (CT) images in a fully 3-D-rendered format," said senior scientist and SNM member Sanjiv (Sam) Gambhir, director of the Molecular Imaging Program at Stanford Univer...

Tiny zebrafish teaches researchers how to fight off a deadly cancer

...cell plasticity and suggest that this experimental paradigm can be a powerful one in which to investigate tumor-microenvironment interactions leading to the reversal of the aggressive phenotype of tumor cells....

Emerging diseases require a global solution

...ill cost more than we can afford. The 'One Health' paradigm can serve as an 'ounce of prevention' for the 21st Century."...

'Punctuated' evolution in the human genome

...A duplications, and it challenges the evolutionary paradigm that continuous alterations occur during the course of genome evolution. The scientists, who are affiliated with the University of Washington (Seattle, WA), Case Western Reserve University (Cleveland, OH), the University of Bari (Bari, Italy), Washin...

University of Chicago study overturns conventional theory in evolution

...discovered a striking phenomenon that challenges a paradigm of molecular evolution that has been around for several decades," said lead author Bruce Lahn, Ph.D., assistant professor of genetics at the University of Chicago and Howard Hughes Medical Institute investigator. "As such, it may cause a significant ...

From memory formation during sleep to novel components for physics

...raction between the cells in the vascular walls a paradigm change in vascular medicine, since the focus is placed upon the role played by the vascular walls in the progress of disease. (Spokesperson: Prof. Karl Plate, Goethe University of Frankfurt am Main) The understanding of hearing in situations of comp...

Making a brain

A long-standing paradigm in developmental biology has been that default neuralization (ie., the differentiation of dissociated ectodermal cells to neural cells in culture) is caused by the dilution and thereby suppression of BMP growth factor signaling. Dr. Edward De Roberti...

JCI table of contents April 1, 2005

...ction in systemic lupus erythematosus: an evolving paradigm AUTHOR CONTACT: Gary M. Kammer Arthritis Associates Inc., Willoughby, Ohio, USA. Phone: (440) 953-8700; Fax: (440) 953-8796; E-mail: gmkammer@hotmail.com View the PDF of this article at: IMMUNOLOGY Ikaros integrates stress and immunity Th...

UF science discovery raises questions about origin of African mammals

...evidence and made a very coherent challenge to the paradigm of molecular studies that you can really infer the breakup of major mammalian groups way back in the Earth's history just by using molecular techniques," Luo said. Shawn Zack, the paper's senior author and a current graduate student at Johns Hopkins...

DNA 'packaging' linked with cancer

... journal says the study represents what it calls a paradigm shift in our understanding of how malignant cells operate. The findings are expected to yield new diagnostic and therapeutic tools in the battle against cancer. Initial experiments at UIC found that the genetic material of cancer cells is knotted-up ...

High cholesterol levels accelerate growth of prostate cancer

...s inhibitory effect. "Our study opens up a new paradigm in thinking about how cancer might be controlled pharmacologically by manipulating cholesterol," says Freeman. "Our data support the notion that cholesterol-lowering drugs -- which are widely used and fairly safe -- might be effective in prevention o...

JCI table of contents, April 1, 2005

...urons and stimulating Pomc neurons. The alternate paradigm increases food intake and leads to obesity. In a study appearing online on March 10 in advance of publication in the April 1 print edition of the Journal of Clinical Investigation, Gregory Barsh and colleagues from Stanford University examine how lep...

Newly-discovered class of genes determines and restricts stem cell fate

...to have this dual role may represent a new general paradigm for developmental and stem-cell biology. "My idea is that this is a new family of genes--they can both determine the cell type, but also put the breaks on differentiation," says Epstein. "We have named them pangenes, after the Greek god Pan and Peter...

New collaborations offer hope for HIV/AIDS vaccine

...hat for the National Institutes of Health, the new paradigm requires expanding beyond basic research. It involves a new focus on product development through alliances with the pharmaceutical industry and other research agencies. "At NIH we are attempting to we strike a balance between the time-honored goals ...

UAlbany CNSE enters NanoBio alliance with Albert Einstein College of Medicine

...oscale Science and Engineering will serve as a new paradigm for cutting-edge research and education," added Dominick P. Purpura, M.D., The Marilyn and Stanley M. Katz Dean of the medical school. According to the memorandum of understanding signed by CNSE and Albert Einstein, the two institutions will focus o...

Brain region learns to anticipate risk, provides early warnings. suggests new study in Science

...gnition, to alter how we think about things." New paradigm for brain's "oops" center" While there is growing consensus about the important role played by the cingulate in complex thoughts and feelings, there are competing theories regarding the cognitive mechanisms that underlie activity there. Recent studi...

Novel sulfide-binding mechanism found in deep-sea tubeworms

... multi-disciplinary approach, replaces the current paradigm for the evolution of worm hemoglobin by demonstrating that hydrogen-sulfide molecules are bound by a metal ion rather than by an arrangement of amino acids." In addition to a very large hexagonal hemoglobin, typical of many worm species, the deep-sea...

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