Dying cells encourage neighbors to grow
...hown to be the case in some cancers, may result in pathological activation of these pathways. "Based on the behavior of undead cells in Drosophila imaginal discs, one might expect mutations that block or delay apoptosis to cause secondary proliferation and hyperplasia. It remains to be tested if such a mechanism ...New genomic method can identify disease-causing genes
...rrelating a pattern of observable physiological or pathological differences among selected strains of mice with a pattern of genomic variation. Using conventional methods, pin-pointing a gene contributing to disease risk could take five scientists five years. With Roche's latest innovation, which has up to 1,000-...Research uncovers role of Apolipoprotein E in Alzheimer's disease
...buildup in the brain of amyloid plaques, the major pathological hallmark of Alzheimer's disease. These deposits of plaques are composed primarily of the amyloid-beta protein (AB). However, the mechanism by which ApoE exerted its ill effects on Alzheimer's disease was unclear. In the first paper*, published in t...How receptors govern inflammatory pain
... that AMPA receptors are important determinants of pathological nociceptive sensitivity and suggests their potential relevance in the therapeutic approaches toward the prevention and treatment of chronic inflammatory pain. Bettina Hartmann, Seifollah Ahmadi, Paul A. Heppenstall, Gary R. Lewin, Claus Schott, Thilo...JCI table of contents, December 15 2004
...platelet activity will need to be specific for the pathological tumor cellplatelet interaction, without effecting normal platelet function. Platelet-specific integrin inhibitors like Integrilin fall into this category. The study also suggests that drug-mediated inhibition of platelet-derived LPA and LPA receptors......rough improved understanding of the biological and pathological processes in the vessel wall. The main topic of her research is programmed cell death (apoptosis) in the blood vessel wall, called the endothelium. Every cell carries in its DNA a kind of self-destruct mechanism, which is set off in response to certa...Where the brain harbors unconscious fears
...s emotional vigilance characteristic of normal and pathological anxiety, as well as a new means for investigating the mechanisms and efficacy of treatments for anxiety states," wrote the researchers. They wrote that "This study provides an experimental probe for unconscious processes that is sensitive to an indiv...Body's biological clock found to affect cardiac rhythm patterns in healthy adults
...ave associated values progressing toward 1.5 with pathological conditions, such as congestive heart failure. When the team analyzed wake period data, they found a striking correlation: values changed according to the internal body clock time. At 2 a.m., the value was 0.8; at 5 p.m., it was 1.0. However, at 10...ASBMB-Amgen Award Lecture to focus on orphan nuclear receptors
...or breast cancer, inflammatory disorders and other pathological states. In contrast, orphan receptors are a subfamily of receptors whose ligands are unknown. The existence of such receptors raises the exciting possibility that numerous signaling pathways remain to be discovered. However, before this potential ca...Study discovers serious deficiencies in 'apparently normal' heart valves
...een ascribed to enlargement of the heart and other pathological problems associated with heart disease, but the new study suggests that changes in the valves themselves may contribute to the problem. This work was hailed as a "paradigm shift" in an accompanying editorial in the same journal. "The most common form...Important discovery about second most fatal cancer
...syndrome is characterized by distinctive clinical, pathological and molecular features: Early age at onset More common in females More common in right side of colon Little evidence of tumour immunity Frequent mutation of an oncogene called BRAF (also mutated in cancer of thyroid, ovary, and melanoma) Frequ...APS announces 2005 Young Investigators Awards
... ion channels in kidney cells. Dr. Ma also studies pathological relevance of the ion channels in certain kidney diseases, such as diabetic and polycystic kidney disease. David L. Allen, Ph.D. University of Colorado, Boulder The Shih-Chun Wang Young Investigators Award This $7,000 award recognizes an ind...Enriched environment delays onset of Alzheimer's in mice
...y beneficial impact, protecting the brain from the pathological hallmarks of this insidious disease." These findin...ve months, the researchers began to search for the pathological signs of AD in the mice's brains. They found that mice from the enriched environment had a dramatic ...Histamine, anxiety and alcoholism
...in the general populations; it is not a measure of pathological anxiety, although individuals with clinical anxiet... in flushing response, allergic diseases and other pathological states in which histamine has a putative or well-established role," said Oroszi....Mutant protein developed by Hebrew University scientists
...l proliferation in cancer, or in controlling other pathological phenomena in which leptin is a factor. Thus far, the researchers have succeeded in creating antagonists of human, sheep, rat and mouse leptins. A company, Protein Laboratories Rehovot (PLR), that was formed by Prof. Gertler and the Hebrew Universi...JCI table of contents April 1, 2005
...n studying the role of low dose aspirin in several pathological conditions, such as preeclampsia, thrombosis and inflammation. The results suggest that low-dose aspirin treatment may prevent preeclampsia without compromising reproductive function. TITLE: Differential impact of prostaglandin H synthase 1 knockdo...Birthing a new model of aspirin therapy in preeclampsia
...n studying the role of low dose aspirin in several pathological conditions, such as preeclampsia, thrombosis and inflammation. The results suggest that low-dose aspirin treatment may prevent preeclampsia without compromising reproductive function....Study supports use of aspirin in treating pregnancy disorder
...ng the implications of low dose aspirin in several pathological conditions, such as pre-eclampsia, thrombosis, and inflammatory disorders," says Dr. Funk. "We're hopeful that our model will lead the way to further treatment options for these debilitating conditions."...Puberty onset influence of nutritional, environmental and endogenous regulators?
... that underlay the onset of normal puberty and its pathological variant, precocious puberty, are still poorly understood. Therefore, in order to understand the possible roles of environmental factors in the aetiology of precocious puberty, PIONEER will also explore the endogenous factors that regulate the physiol......ow that plasmin joins another protein, MMP-9, in a pathological signaling pathway during the early phase of disease. According to a related commentary by Kim Yancey of the Medical College of Wisconsin, these results "will facilitate the development of effective interventions that counteract the chronic morbidity...