Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
...erscores the relevance of the NF-κB signaling pathway as a target for MM therapy. MM is a cancer of th...es abnormal activation of the NF-κB signaling pathway as a key event in MM pathology. NF-κB target genes are known to be involved in cell proliferati...Interaction of just 2 genes governs coloration patterns in mice
...lty of Arts and Sciences. "It also illuminates the pathway by which these two genes interact to produce disti... coloration. There's reason to believe this simple pathway may be evolutionarily conserved across mammals that display lighter bellies and darker backs, from m...New, more direct pathways from outside the cell-to-cell nuclei discovered
...rs has shattered a long-held belief that no direct pathway exists between material outside of a cell and the cell nucleus. (The cell is the smallest metabolically functional unit of life.) It was already known that material outside of a cell can migrate into a cell. This occurs through processes known as e...No evidence that widely prescribed statins protect against prostate cancer
...debate, however, by suggesting that any protective pathway offered by statins, if it exists, is not through androgen suppression. ...Antioxidant overload may underlie a heritable human disease
...rugs or other treatments targeting the antioxidant pathway through G6PD might modify the phenotype and the natural history of this inherited disorder in humans, according to the researchers. The results found in the heart suggest that reductive stress might underlie other diseases, as well. Our findings op...JCI table of contents: Aug. 9, 2007
...er analysis revealed that Bcl-2 inhibited only one pathway of apoptosis activated by the sustained inflammatory response the intrinsic apoptotic pathway of cell death. The extrinsic apoptotic pathway of cell death proceeded unchecked. These data led the...Preclinical study links gene to brain aneurysm formation
...NOS-3 gene is just one step in a complex molecular pathway that links flow-dependent vascular remodeling to intracranial aneurysm formation. Our findings suggest that if something goes wrong in the vascular remodeling process, it could trigger formation of an aneurysm, he adds. Abruzzo reports these fi...Genetic factors strongly shape how peers are chosen
...iological, Kendler said. An important part of this pathway involves our genetics influencing our own social e...trate clearly that a complete understanding of the pathway from genes to antisocial behaviors, including drug abuse, has to take into account self-selection in...Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
... of blood cells involves a complex differentiation pathway with interactions between many molecular players and proteins. In humans, there are four globin genes clustered on chromosome 11 in the order in which they are turned on or expressed. These genes include the epsilon-globin gene, two gamma-globin g...New mechanism links smoking to lung damage
...it could cause." Hemichannels form a small gated pathway from the interior of a cell, through the cell membrane to the cell surface. They usually connect with an identical hemichannel from an adjoining cell to form a gap junction. By directly connecting two cells, gap junctions enable them to exchange the ...A sensory organ, not the brain, differentiates male and female behavior in some mammals
..." Dulac says. "In this model, only the vomeronasal pathway itself -- which serves as a switch that represses male behavior while promoting female behavior -- is dimorphic. While male and female bodies are strikingly different physiologically, it appears the same cannot be said for the brain." Dulac and col...Immunity in social amoeba suggests ancient beginnings
...TirA), Kuspa and his team found. This signaling pathway or a very similar one is present in plants and animals, he said. Now it has been identified in amoeba. It has not been found in fungi. Amoeba have, in the last 10 years, become appreciated as one of the four main forms of life in the crown group o...Penn researchers discover pathway that eliminates genetic defects in red blood cells
...ool of Medicine have discovered a unique molecular pathway that detects and selectively eliminates defective ...ions in RNAs. For example, the most well-described pathway is one that recognizes nonsense mutations that result in an RNA that makes a protein that is too sho...Progesterone therapy and preterm birth: More evidence helps identify women who can benefit
...e, progesterone may be more effective against some pathway that does not involve the uterine over-distention seen in twin pregnancy. We need more research into the underlying causes of prematurity to help women with other risk factors, Dr. Katz said. ......hat were engineered to over-express specific miRNA pathway components. They introduced exogenous let-7 miRNAs and monitored its effects on the translation of luciferase reporter mRNA. The researchers found that let-7 miRNAs recruited miRNP complexes containing Ago2 and GW182 proteins to target mRNAs, res...Research teams uncover risk genes for multiple sclerosis
... genomic studies have honed in on the main genetic pathway associated with multiple sclerosis (MS), while als... IL-7R, he said. Together, these place the IL-7R pathway at the center of understanding MS pathogenesis, Hauser said. I believe that this receptor and its in...MIT model could predict cells' response to drugs
...tcome of the calculations is different because the pathway activities are different," said Lauffenburger. The researchers also tested the model on a type of blood cell, but in this case, it failed to accurately predict behavioral outcomes. The fact that a model developed with colon epithelial cells only wo...Researchers find pathway that controls cell size and division
...bility. This sensor is comprised of a three enzyme pathway that was previously shown to be involved in synthe...e cell membrane. The Levin labs data indicates the pathway also has a major role in cell division. So far this has been the only pathway thats been identified ...Prenatal stress keeps infants, toddlers up at night, study says
... more research is needed to monitor this signaling pathway more closely, watching for biological hints as to why sleep and behavioral disturbances so often crop up together. In the meantime, pregnant women concerned about how their own mood-disturbance may harm their unborn babys sleeping habits, developme...... the (alcohol-regulated) genes are involved in the pathway for cleaning things up," Wiren said. The genes respond with "removal of damaged proteins. The females have all this apoptosis (cell death) going on, and the males instead may have repair going on." Such brain damage may underlie debilitating cognit...