Tag: "pathways" at biology news
Unravelling new complexity in the genome
...nes operating in the same biological processes and pathways
are regulated by alternative splicing differently in nervous system tissues compared to other mammalian tissues, says lead investigator Professor Benjamin Blencowe of the Banting and Best Department of Medical Research and Centre for Cellular and Bio...
Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
...and interplay between them, there are two separate pathways
that lead to activation of NF-κB, the classic...e of both the classical and alternative NF-κB pathways
in MM pathogenesis. Most MM patient samples examined exhibited NF-κB pathway activation via div...
High blood pressure, low energy -- a recipe for heart failure
...dminister drugs that would rev up energy-producing pathways
such as those controlled by ERR alpha, according to Kelly. Kelly is also director of the Center for Cardiovascular Research and professor of medicine, of pediatrics and of molecular biology and pharmacology. ERR alpha sits in the nucleus of cells an...
New, more direct pathways from outside the cell-to-cell nuclei discovered
... The team's discovery of the existence of direct pathways
between extracellular material and cell nuclei wil...). Gavin says that these newly discovered direct pathways
mean that "internalized material does not necessarily have to exit the phagosome before entering the...
Antioxidant overload may underlie a heritable human disease
...o the release and storage of energy. Many cellular pathways
are also sensitive to the prevailing redox conditi... reactive oxygen species, triggering antioxidative pathways
to kick in. In the diseased animals, however, that pathwayin which oxidized glutathione is recycled ...
JCI table of contents: Aug. 9, 2007
...modeling through activation of multiple cell death pathways
AUTHOR CONTACT: Douglas L. Mann Baylor College o...re calories than they burn. However, the molecular pathways
that control feeding behavior and cellular energy expenditure are highly complex and not completely ...
Study finds gender differences in renal and other genes contributing to blood pressure
...notypes at 35 gene locations involved in two major pathways
regulating blood pressure, kidney or adrenergic or...es involved in two major blood pressure regulation pathways
to identify gender differences in genetic contribution to blood pressure. The results reinforce pre...
Preclinical study links gene to brain aneurysm formation
...press (knock out) one of three genes and molecular pathways
associated with vascular disease: inducible nitric oxide synthase (NOS-2), endothelial nitric oxide synthase (NOS-3) or the plasminogen activator inhibitor (PAI-1). To determine whether absence of the genes resulted in an increased rate of aneurys...
Disabling a sensory organ prompts female mice to act like male mice
... avenue to explore the molecular and physiological pathways
that lead to differences in sexual behavior, according to Dulac. "Now we can really approach things from a mechanistic point of view," she said. "We can trace signaling events in the brain and see how brain areas controlling sex-specific behaviors ar...
News tips from ACS Chemical Biology
... estrogen and testosterone activate cell signaling pathways
Helper peptides that can influence the opening of calcium channels in cell membranes A new technique called the double barrel shotgun approach that helps pinpoint key cellular proteins How tricking cells with a mimic of a chemica...
Taming the anthrax threat
...escaped to spread further. They identified several pathways
and functions that helped the microbe survive and thrive, which could be targets for future drugs. Among a large number of genes shown to be highly active, the scientists picked one to study further, a previously uncharacterized gene in the MarR fa...
How a pain in the neck could be bad for your blood pressure
... a team led by Professor Jim Deuchars has examined pathways
between the neck and the brain to show how the nec...eople, Prof Deuchars explained. By identifying the pathways
we can see why these treatments might work and it could also explain why some people suffering whipl...
Penn researchers discover pathway that eliminates genetic defects in red blood cells
...ve messenger RNAs from red blood cells. Other such pathways
known as surveillance pathways
operate in a more general way, in many cell types. Knowing how this specific surveillance system wo...
Identifying the mechanism behind a genetic susceptibility to type 2 diabetes
...igate the potential for manipulating the signaling pathways
controlled by TCF7L2 for the development of new therapeutics for type 2 diabetes....
Progesterone therapy and preterm birth: More evidence helps identify women who can benefit
...ment from those who are not. Dr. Katz noted that pathways
to preterm birth may differ substantially between singleton and twin gestations. For example, progesterone may be more effective against some pathway that does not involve the uterine over-distention seen in twin pregnancy. We need more research i...
JCI table of contents: August 1, 2007
...igate the potential for manipulating the signaling pathways
controlled by TCF7L2 for the development of new therapeutics for type 2 diabetes. TITLE: Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes AUTHOR CONTACT: Valeriya Lyssenko Lund University, University Hospita...
Molecule blocks gene, sheds light on liver cancer
...e, he explained. This, in turn, activates chemical pathways
that enable cancer cells to proliferate, migrate a...PTEN levels to drop. They also traced the chemical pathways
that increased the cells' abilities to proliferate, migrate and invade other tissues. Our finding...
MIT model could predict cells' response to drugs
...he model is based on similarities in the signaling pathways
cells use to process information. Those pathways
translate cells' environmental stimuli, such as hormones, drugs or other molecules, into action. "...
JCI table of contents -- July 26, 2007
...in cholesterol, these receptors activate signaling pathways
that remove diet-derived cholesterol from the body. Two types of LXRs LXR-alpha and LXR-beta are therefore potential targets for the development of anti-atherosclerosis drugs. However, the effects of synthetic drugs that activate these two receptor...
Gene-transcription machinery seen poised for action, held in check until needed
...ady to send the cells down various differentiation pathways
to form different tissues. There are likely many vital cell functions that depend on a quick response which could be regulated by this process. In earlier work, Berger and her coworkers looked at ways in which the addition and removal of a small pr...
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