New therapy for specific form of leukemia
...Existing drug now used with T-ALL patientsResearch performed by Jan Cools and his colleagues, under the direction of Peter Marynen, shows for the first time that ABL1 also lies at the root of T-ALL − which has a direct effect on the treatment of T-ALL patients. Indeed, a drug exists − called Glivec...Commandeering cellular machinery: recognition mechanism to detect small molecules
...me significantly more sensitive than others. Some performed the function of on-off switches, while others were more like dimmer switches, responding in proportion to the amount of LG335 bound to them. Doyle's team also studied their re-engineered receptors in mammalian cells and found they behaved much the s...A treatment, not a cure: Calcium silicate neutralizes an acidic stream
...m silicate, on an acidic stream. The research was performed at the Hubbard Brook Experimental Forest, located in the White Mountains of New Hampshire. Likens, who discovered acid rain at Hubbard Brook in the 1960s, has been investigating human-accelerated environmental change there for over four decades. A ne...Mayo Clinic awarded major NIH contract for smallpox genomics research
... in the effort. Genotyping of genomic DNA will be performed by the Mayo Genotyping Share Resource (GSR), a core laboratory under the direction of co-investigator Julie Cunningham, Ph.D. Other aspects of the research including bioinformatics -- the processing of the huge number of data points in this type of ...NIH funds first nationaL SNP genotyping center at Broad Institute
...R-funded Broad Institute genotyping center will be performed in early 2005. Researchers interested in access to the center or applying for subsidized genotyping should contact the Broad Institute at ncrr_gc@broad.mit.edu or refer to the Broad Institute Web site, www.broad.mit.edu , which will contain detai...Most promising clinical uses for stem cells from fat agreed on by international society
...s. More than 300,000 liposuction procedures are performed in the United States each year, producing about 150,000 gallons of fat that is normally discarded. In 2001, researchers first reported that such tissue contained stem cells, and since then, additional studies have suggested they can be coaxed into ot...Does a time delay between prostate cancer diagnosis and start of radiation treatment matter?
...re than nine months (n=67). A second analysis was performed which evaluated outcomes at the median time to treatment of 3.2 months. "Our findings show that a delay, within the limits of this study, from the time of diagnosis to the start of treatment with external-beam radiation does not alter ultimate clinic...Forum at Virginia Tech to address issues of human cloning
... by the looming possibility of cloning. It will be performed at 5 and 8 p.m. in the Squires Student Center Studio Theatre Oct. 27-29. "We are very fortunate to have an acclaimed play by a world-class playwright that is a perfect fit with the themes of the forum," says Daniel Breslau, co-director of Choices...Society for Psychophysiology Research
...caine users and normal control subjects while they performed a short-term memory task. Results showed that poor performance of cocaine users on the memory task was associated with below normal levels of activity in areas of the brain involved with paying attention and manipulating information in short-term me...Sedentary overweight people get insulin boost from short term exercise; CVD risks trend down
... changes in CVD risk factors. Both studies were performed on the same groups by Steven E. Black (a doctoral student) and Elizabeth Mitchell (an undergraduate honors student), both working in the laboratory of Barry Braun in the Department of Exercise Science, University of Massachusetts, Amherst. Black will...FSU scientist links iron imbalance to Parkinson's disease
...hat regulate gene expression." Levenson performed the mouse model portion of the study in collaboration with Mark Mattson, Laboratory of Neurosciences chief at the National Institute on Aging in Bethesda, Md. Mice were fed varying amounts of iron to determine levels that precipitated onset or hasten...Acoustics meeting in San Diego
...( lac@apl.washington.edu ) and his colleagues have performed a series of experiments that suggest even modest levels of underwater sound could trigger bubble formation in a liquid of supersaturated nitrogen. The supersaturation levels can result in very large nitrogen bubbles, which could have potentially del...Rutgers-led research offers new clues in the genetic mysteries of maize
...most comprehensive survey of the maize genome ever performed and established for the first time the genome's magnitude approximately 59,000 genes and the relative position of the genes. This is twice as many as the human genome and the highest number of genes of any genome sequenced to date. Messing emphasiz...Research into the sense of touch in worms wins Eppendorf/Science Prize
... described in a 1,000 word essay based on research performed within the last three years. The grand prize winner receives $25,000 from Eppendorf, and the winner's essay will be published in the 15 October 2004 issue of Science . Two finalist essays will be published at Science Online ( http://www.scienceonlin...An old adage about apples finds scientific backing
... But the second class, featuring the procyanidins, performed well on both tests. First, they triggered cell signaling that activated a cascade of chemical reactions resulting in apoptosis, a critical step in halting cancer cell growth and spread. "This part of the study helped determined a key mechanis...Discovery might improve design, effectiveness of anti-cancer drugs
...evel. The instrument in which the experiments were performed is located at the North American headquarters of Bruker Daltonics in Billerica, Mass. The Michael Hooker Proteomics Core Facility will soon acquire one of the sophisticated mass spectrometers, said Borchers, also a member of UNC's Center of Environme...To save dolphin's dorsal fin experts combine medical technology and teamwork
... patch. Drs. Stone and Sweeney lead the team that performed the procedure, which included Dolphin Quest veteri...d LED therapy. Human cosmetic surgeon Dr. Faringer performed the initial procedure in July that prepped Liko's wound for the sequence of fin-saving treatments to...Babies born after surgery on eggs
TWENTY children have been born after doctors performed a kind of transplant surgery on the eggs of their mothers, for whom normal IVF had failed. But other experts are concerned about the long-term safety of the technique. The technique, developed by Chii-Ruey Tzeng's team at Taipei Medical University in...For inferring the biological tree of life, simple is better
...f the evolutionary tree. Thornton and Kolaczkowski performed their experiments on a small supercomputer they assembled in the Thornton laboratory by linking together a cluster of Apple personal computers. The project was funded in part by a National Science Foundation grant to the UO to train graduate students...... and extension, essentially the work that would be performed by two enzymes, are the most efficient of any know...n preserving the integrity of the genome. Research performed at the Jackson Laboratory and published in Molecular and Cellular Biology in tandem with Pitt's stud...