Computer simulation hints at new HIV drug target
...ed a computer simulation program called AMBER that performs several different types of calculations. The x-ray crystal structure of the molecule is used as the input, and the various motions and shapes sampled are governed by Newtonian physics, the electric forces among atoms, the complementarity or clash of ...Argonne researchers contribute 1000th structure
...tructure provides insight into how the biomolecule performs its task. For example, biologists determined how bacteria communicate by a mechanism called quorum sensing using the TraR protein to activate genes of an agricultural pathogen that causes tumors in plants. Bacteria release and sense chemical signals ...Surprise! Computer scientists model the exclamation point
...veloped a measure of saliency. A parallel analysis performs similar operations, but does so over time, not space, looking for new elements suddenly appearing. This approach is said to model "novelty." Finally, an analysis can be done purely in terms of Shannon's original equations, which can measure the level......ndaries not captured in DNA sequences. The barcode performs best in identifying individuals against a well-annotated sequence database--as demonstrated here with ESUs--and the authors argue that the barcoding movement is well-equipped to help in this effort. But barcoding methods for discovering new species n......aves much like a sprinter, whereas the whole cargo performs a marathon. Scientists of the Max Planck Institute of Colloids and Interfaces in Potsdam have now provided a simple solution to this puzzle. If the cargo is pulled by several motors as shown in Fig.1, any motor that unbinds from the filament will st...Study finds protein is required for human chromosome production
...f Medicine have identified an elusive protein that performs a necessary step in the production of human chromosomes. The new study appears in the most recent issue (Oct. 7) of the journal Cell. The study found that a protein called CPSF73 acts like scissors to cut strands of histone messenger RNA (mRNA) in ...Defense center at NJIT draws satisfied customers at annual signing
... soil and ground water remediation. The firm also performs health and safety work, chemical inventory, report... disabled veteran. He founded a small company that performs general construction work. But when he tried to firm up a contract with a government agency, he ran...Scientists get first glimpse at how plants, most animals repair UV-damaged DNA
...ng's work has revealed how the water in the pocket performs a critical function at this point. When the photolyase enzyme becomes excited, it jostles the water molecules, and that motion within the pocket delays the electron's exit from the dimer until just after the repair is done. As far as scientists can t...Scientists get look at genes' defensive playbook
...Genetics Institute and director of the UF lab that performs genomic analyses for the consortium. "Initially, more than half of the genes became less active, but over the long haul, they were more focused on the inflammatory response. By drawing samples for analysis over six time points in 24 hours, we were ab...Chemical Society announces EPA awards for environmentally friendly technologies
...BASF Corp. created an automobile primer paint that performs as well as conventional versions, with less than h...DM) developed a component of latex paint that that performs better than the conventional, volatile compounds that are used to give paint its smooth, consistent ...The lopsided brain: Attention bias is shared by humans and birds
...of the visual world seems nonexistent as the brain performs spatial tasks. In a classic example, a patient asked to draw a daisy can only manage to put petals on the right side of her drawing. The more subtle leftward bias in attention present in healthy humans likely has to do with asymmetries in the wiring ......the majority of membrane proteins, gamma-secretase performs its proteolytic function neither inside nor outside the cell; instead, the crucial cut is made within the cell's thin membrane. In fact all the proteins and protein complexes involved -- APP and the alpha, beta, and gamma secretases -- are cell-membr...Motor transport in bio-nano systems
...After a few seconds, it unbinds from its track and performs random Brownian motion in the surrounding water until it rebinds to the same or another filament. In order to understand the motor traffic in biological cells and in biomimetic systems, it is necessary to go beyond the single motor level and conside...From photovoltaics to solar thermal collectors: Evaluating and improving green design
...provided by its own PV system. While the building performs to a very high standard, the process of monitoring the facilities actual performance has uncovered some energy use inefficiencies. In addition, an overheating computer room located on the ground floor in a space not easily vented; electrical usage th...Cleaner shrimp use rocking dance to advertise their service to clients
...mall crustacean, the yellow-beaked cleaner shrimp, performs a specialized dance that affects the behavior of large, predatory client fish. This signaling represents shrimp-to-fish communication that allows both hungry cleaner shrimp and parasite-laden client fish to benefit from a non-predatory, "cleaning" in...Ophthalmologists and physicists team up to design 'bionic eye'
...to explore parameters and come up with a chip that performs optimally. Another design--pore electrodes--involves an array of cavities with stimulating electrodes located inside each of them. How does the system work when viewing, say, a flower? First, light from the flower enters the video camera. (Keep in mi...Autism linked to mirror neuron dysfunction
...ey-see, monkey-do cells" fire both when a monkey performs an action itself and when it observes another living creature perform that same action. Though it has been impossible to directly study the analogue of these neurons in people (since human subjects cannot be implanted with electrodes), several indire...Bird brains show how trial and error may contribute to learning
...y one scratchy tune learned in its youth, which it performs repeatedly and intensely when females are listening. But occasionally, the finch might improvise, experimenting with a slower, more sultry variation or emphasizing different notes. Neurobiologists studying the finch now say the improvisation arises f...Wider use of simpler cervical cancer screening could benefit women in developing countries
...th vinegar for one minute. Then, the health worker performs a naked-eye observation of the cervix to see whether the epithelium, a protective tissue layer, turns white. This would indicate precancerous lesions. Dr. Jeronimo said that "it has always been said that this VIA method was only applicable" in low-i......pect that the human variant of this protein, E2F7, performs the same essential function in human cells. Their ...the E2F7 protein - the human counterpart to DEL1 - performs a function in human cells analogous to that of DEL1 in Arabidopsis. According to these scientists, a...