Tag: "peripheral" at biology news
$6.7 million for bionic war on disabilities
...one of which is to implant these electrodes in the peripheral
nerves of the legs of a paraplegic," says Normann. "We believe that if we implant three Utah Electrodes Arrays into three different nerves in each leg a total of six electrode arrays and stimulate them appropriately, we should be able to help the p...
FDA approves ABRAXANE(TM) for metastatic breast cancer
...vity reactions, severe myelosuppression, prolonged peripheral
neuropathy and severe edema," said Edith Perez, M....e patients. In the patients who developed Grade 3 peripheral
neuropathy, rapid improvement occurred after a median of only 22 days. It is significant that ABRAX...
Blood test shows promise as monitor for antiangiogenic cancer therapy
...ntitumor dose. The authors conclude that measuring peripheral
blood cells can be used as a reliable surrogate fo...nesis. "Our results highlight the possibility of a peripheral
blood-based cellular assay to both measure and monitor angiogenesis, as well as to monitor antiangio...
Fat deficiency gene also spurs obesity
...rchers. The gene might therefore represent a novel peripheral
target for the treatment of obesity and lipodystrophy, they said. The finding further suggests that differences in lipin might contribute to the natural range of fat levels found among people. The group, led by Karen Reue of the David Geffen School o...
Gene with broad role also causes prevalent, inherited nerve disorder
...e types of defects that might, in general, lead to peripheral
nerve disorders. "As the function of each new gen...messengers, or neurotransmitters, in nerves of the peripheral
nervous system. The protein is also critical for maintaining the network of "microtubules" that con...
JCI table of contents
...ymic Alcatraz TITLE: An affinity/avidity model of peripheral
T cell regulation. AUTHOR CONTACT: Hong Jiang Department of Medicine, Columbia University, New York, New York, USA. Phone: 212-305-9988; Fax: 212-305-4943; E-mail: email@example.com . This article is available at http://www.jci.org/cgi/content/full/1...
New component of the 'brakes' on nerve regeneration found
...inery in neurons that prevents regeneration. While peripheral
nerves have no such machinery and can readily regenerate, central nervous system (CNS) neurons have their brakes firmly in place and locked. Now, two groups of scientists have independently found a new component of that braking machinery, adding to u...
Lost tolerance is a grave Omenn
...f T cells that escape thymic selection, infiltrate peripheral
tissues, and cause autoimmune reactions. The origi...n-specific autoimmunity. In the presence of AIRE, peripheral
self-antigens are presented and autoreactive T cells are eliminated whereas in the absence of AIRE, ...
JCI table of contents March 1, 2005
...on, mice lacking EP2 exhibit short lasting pain of peripheral
origin, but completely lack long-lasting central pain. The mice have subdued transmission of pain signals. The findings indicate that targeting a single prostaglandin receptor subtype, EP2, can control chronic pain, as opposed to non-specifically bl...
Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves
... one meter in length. Nerve cells belonging to the peripheral
nervous system can regrow when their axons are damaged. But how does the damaged axon inform the cell body that it must start producing vital proteins for the healing? That's precisely where the molecular messengers, proteins called Erk-1 and Erk-2, ...
Cure no quick fix for cancer survivors on long road to recovery
...stimated 30,000 Americans undergo a bone marrow or peripheral
blood stem cell transplant, typically a procedures of last resort. Both types of transplantation aim to restore patients' blood stem cell counts after their own stem cells have been wiped out by high-dose chemotherapy or radiation therapy used to tre...
Scientists discover that host cell lipids facilitate bacterial movement
...he bacterium through the cell until it reaches the peripheral
or outer cell membrane," explains Dr. Frederick Southwick of the University of Florida College of Medicine. "Here the growing actin filaments push the bacterium against the membrane, forming long membrane projections called filopodia. These filopodia...
South America's vast pantanal wetland may become next everglades, UNU experts warn
...erse ecosystems, is at growing risk from intensive peripheral
agricultural, industrial and urban development problems expected to be compounded by climate change, United Nations University experts warn. Covering more than 165,000 square kilometers an area roughly equal to Florida in the heart of South Americ...
Neuroscientists locate 'imaginary' colors
...y letters or numbers in a crowded display in their peripheral
vision. These differences had been observed by scientists before, but it was difficult to gauge whether these were due to variance in the synesthetes or were primarily artifacts of differing research methods, Hubbard said. The current study, the fi...
15 generations of untrained jocks, couch potatoes show big physiological adaptations
...h potatoes." These differences were mainly due to peripheral
improvements (skeletal muscle) rather than central physiological changes in the cardiovascular or respiratory systems. Wider endurance, oxygen usage differences reflect system-wide changes As would be expected, the UCSD physiologists found that t...
In asthma, it's not the drugs but the inflammation that increases cardiovascular risk, damage
...ol. Circulating neutrophils were isolated from the peripheral
blood and examined for their activation state by measuring stimulated release of the enzyme myeloperoxidase. Neutrophils isolated from asthmatic animals showed an enhanced rate of MPO release compared to those from control animals (substrate consumpt...
Alcohol 'binges' in rats during early brain development cause circadian rhythm problems
... the clock timing these cycles in the brain and in peripheral
tissues, such as the liver, that need to coordinate their own physiological activities with the core clock in the brain....
Ophthalmologists and physicists team up to design 'bionic eye'
...00 vision. Many AMD patients retain some degree of peripheral
vision. "Currently, there is no effective treatmen...mages, it allows patients to utilize any remaining peripheral
vision while making the most of the implant. Virtual reality systems that allow co-alignment of real...
Why do amyloid diseases strike different tissues?
...ter to form larger amyloid plaques that deposit in peripheral
nerves, organs, and sometimes in the central nervo...the heart, others cause the fibrils to form in the peripheral
nervous system, and still others cause the fibrils to form in the gut or in the brain. In the latest...
Scientists use transcription factors to increase insulin production in diabetic mice
...e released insulin facilitates glucose uptake into peripheral
tissues such as muscle and fat and suppresses glucose production in the liver in order to maintain glucose tolerance. In contrast, under diabetic conditions, beta-cell dysfunction and insulin resistance are often observed, which disturbs glucose tole...
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