Genetic testing helps physicians zero in on eye disease
... Among the outward signs and symptoms are loss of peripheral vision, night blindness, and abnormal results from an electroretinogram (ERG), a test that measures the electrical activity and function of the retina. A patient with the autosomal recessive form of the disease (arRP) has inherited one gene from eac...Defect in gene causes 'neuralgic amyotrophy'
... Neuralgic Amyotrophy is a painful disorder of the peripheral nervous system. This heritable disease causes pro...factors, make this disorder unique in the group of peripheral nervous system disorders. Therefore, HNA is a genetic model for more frequently occurring disorders ...Researchers discover gene mutations associate with a chronic pain syndrome
...r this disabling condition, which short-circuits a peripheral nerve center called the brachial plexus, a network of over 100,000 nerves, that branches from the spinal cord to supply muscular function and sensation to the shoulders, arms, and hands. HNA may first appear in the childhood or teen years, and lead t...Study: 'Run-down feeling' with illness may last longer as people age
...in the brain compared to younger adults when their peripheral immune system was experimentally activated," said ...cells -- key immune cells in the brain -- during a peripheral infection. It is important that the peripheral immune system inform the brain of an infection, Johns...New stem cell transplantation technique may match donor for every patient
...The novel negative depletion strategy of mobilized peripheral haploidentical stem cells was performed for the first time by the research team. The Role of Graft Engineering in Transplantation Rupert Handgretinger, M.D., St. Jude Children's Research Hospital, Memphis, TN. Tuesday, Oct. 18, 8:45 AM Rates of Apla...Hope for arthritis, heart attack, stroke relief found in unique 'acid active' receptor
...other things how the nervous system interacts with peripheral tissues. They note that "a neurogenic contribution to arthritis has long been appreciated with multiple case reports of arthritis sparing or reversing on the patient's paralyzed side after stroke or nerve injury." Working with Burgess Christensen, th...Expression Project for Oncology (expO) collects 1,000th malignant tumor specimen
...aining normal, paranormal and malignant tissue and peripheral blood samples. "What IGC has accomplished in terms of the expO project could potentially accelerate cancer research," said Franklyn G. Prendergast, M.D., Ph.D., Director of the Mayo Clinic Cancer Center and the Edmond and Marion Guggenheim Professor ...New ECCO 13 studies probe impact of haematological cancer therapy on future fertility
... given. If the disease recurs then bone marrow and peripheral blood transplants are recommended. Immunotherapy including monoclonal antibody therapy are currently under investigation as future therapy options. 3...Light-induced hormone surge points to benefits of light therapy
...e response, and the timing of circadian rhythms in peripheral organs. Therefore, light-induced secretion of gluc...d corticosterone release may entrain metabolically peripheral clocks to the environmental light-dark cycle through its prevailing receptors located in virtually a...Recycled or revamped therapeutics find novel anti-cancer applications
...ted predominantly in transient skin rash, fatigue, peripheral neuropathy and constipation. One patient, however, developed a deep vein thrombosis and pulmonary embolism. The Efficacy of Novel Benzoylphenylureas Analogs in vitro and in a Novel Pancreas Cancer Direct Xenograft Model, and its Relationship with M...Deleted genes help predict outcome in a children's cancer
...priate treatment for the cancer, which strikes the peripheral nervous system. The approach used may also be applied to customizing care for other cancers. "Identifying more accurate risk levels of this cancer allows doctors to treat aggressive types of the cancer appropriately, while not subjecting children wit...UCSF study finds nerve regeneration is possible in spinal cord injuries
...sts of the brain and spinal cord, and those of the peripheral nervous system (PNS), which is the network of nerv...shown in animal studies that an injury made to the peripheral branch prior to a spinal cord injury provided the essential communication signal that enabled the CN...Pall filtration technology verified to remove arsenic from drinking water
...have also found that arsenic harms the central and peripheral nervous systems as well as heart and blood vessels and may also cause birth defects and reproductive problems. The new EPA arsenic standard, which became effective in February 2002, was developed in response to these public health and safety concern...Cancer scientists call for a large-scale human epigenome project
...lution. Tissues proposed for this analysis include peripheral blood cells and foreskin fibroblasts. Participants agreed that a much larger group of samples could be examined using a lower resolution "scanning" approach that would help delineate basic principles of epigenetic effects on gene activity. The scann...JCI table of contents: December 15, 2005
...but also for those individuals with other forms of peripheral nerve damage of known genetic origin. TITLE: Intramuscular viral delivery of paraplegin rescues peripheral axonopathy in a model of hereditary spastic paraplegia AUTHOR CONTACT: Elena I. Rugarli National ...Standing up to paraplegia with gene therapy
...but also for those individuals with other forms of peripheral nerve damage of known genetic origin....FDA grants REVLIMID NDA approval
..., nasopharyngitis, arthralgia, pyrexia, back pain, peripheral edema, cough, dizziness, headache, muscle cramp, dyspnea, and pharyngitis. "Being able to use an oral therapy such as REVLIMID to treat del 5q MDS could reduce or even eliminate the need for red blood cell transfusions in MDS patients," said Dr. Joh...Evolutionary shifts in olfactory sensitivities in fruit flies
...for fruit flies in the genera Drosophila. Both the peripheral and the central olfactory systems have been mapped in detail in D. melanogaster, an important model organism for research. However, nine sibling species of D. melanogaster are less well characterized. One of these species, D. sechellia--as its name s...Brain plays key role in diabetes therapy
...nce thought that insulin's effects were limited to peripheral body tissues that respond to the hormone by importing glucose. However, more recent studies have revealed that insulin receptors in the brain also play an important role in normal blood sugar control. To extend those findings to the disease state in...Darkness unveils vital metabolic fuel switch between sugar and fat
...Clps expressed not only in their livers but in all peripheral tissue except the brain and kidneys. "This is th...se circulatory level determines the balance of the peripheral organ energy supply between glucose, glycogen and fat," the authors conclude, raising the longer-ter...