Diabetes complications rooted in faulty cell repair
...gal said. The inability of the cells to repair the peripheral vasculature, the large vessels of the body, is similar to their inability to repair the small vessels within the eye, he added. "In the vasculature it leads to atherosclerosis, and within the eye it leads to diabetic retinopathy," he said. "So the li...Undergraduate researcher turns up the heat on hibernation
...at replacement of epinephrine or adrenaline to the peripheral nervous system, and not to the brain, determines whether an animal enters torpor. "We could replace the neurotransmitters in the brain and still not get torpor in these mice," Smith said. Torpor was restored when the neurotransmitters were made avail...Discovery of new gene for rare nerve disease may help doctors understand more common illnesses
...r, affecting one in 2,500 people and involving the peripheral nerves, which are the structures that connect the brain and spinal cord to our muscles, skin and internal organs. Half of those who have CMT have one type of the illness due to a mutation in one particular gene, and the other half have one of many o...Kereos presents at AAAS, discusses nanotech-based disease diagnosis and treatment
...ndications such as atherosclerosis, restenosis and peripheral vascular disease at the American Heart Association 2005 Scientific Sessions. This technology was developed at Washington University in St. Louis, one of the NCI's designated Centers of Cancer Nanotechnology Excellence. Kereos President and CEO Rober...Ironman study redefines fine-tuned: Balance training time with blood pressure variability
...erial blood pressure/cardiac index (TPRI, or total peripheral resistance index), and diastolic blood pressure lo...n the arterial vessels responsible for maintaining peripheral resistance and hence blood pressure. The 10 second rhythm is maintained by the sympathetic nervous s...Fine particles increase hospital admissions for heart failure and cardiovascular disease
...heart rhythm disturbances, cerebrovascular events, peripheral vascular disease, ischemic heart disease, chronic obstructive pulmonary disease and respiratory infection), as compared to fine particulate matter levels for 204 U.S. urban counties from 1999 to 2002. The study included 11.5 million Medicare enrollee...Manipulating single cell receptor alters animal behavior
... wealth of information about the interface between peripheral hormones and central control of behavior. "A good deal of attention had been paid to the intracellular signaling pathways under the control of the receptors for angiotensin," he says, "but our research makes strides toward understanding how these pro...News tips from the Journal of Neuroscience
...p of abnormal Schwann cells that fail to myelinate peripheral axons and often bear a mutation in the neurofibromatosis type 2 (NF2) gene. NF2 normally suppresses signaling by Rho family GTPase that regulate actin cytoskeleton dynamics. Rac expression is increased in schwannoma cells, suggesting a possible role ...Molecular discoveries aim at advancing early diagnosis of cancers
...ression test to interpret the possible reaction of peripheral blood cells in response to environmental changes i... of 58 genes that were differentially expressed by peripheral blood cells in the presence or absence of breast cancer. An array platform with 22,000 probes interp...NJIT students present leading research during Provost's Student Research Showcase
... on normal cells. By locating the cells within the peripheral blood of patients, her method could lead to an early detection of metastatic cancer cells. "The technique works in earlier detection of metastatic cancer cells," said Shah. "My research could lead to molecular characterization of circulating cancer ...First clinical results reported for Sangamo's ZFP therapeutic
...growth factor (VEGF-A) in diabetics suffering from peripheral neuropathy. The study, designed primarily to test...n trial in patients with mild to moderate diabetic peripheral neuropathy. Twelve subjects were treated, with SB-509 administered by intramuscular injection in a ...Carbon monoxide inhibitor controls traumatic bleeding, Tulane University researchers show
...Carty said. "We're looking at CO's function in the peripheral circulatory system, in particular, at the effect it has on the endothelium." A serious laceration damages the vascular endothelium, comprised of cells lining the blood vessels, by pulling and tearing it. When the endothelium is torn, it disrupts the...News tips from The Journal of Neuroscience
...tacts, the authors examined the OFF pathway of the peripheral retina in dichromatic (redgreen color blind) and t...ision. Thus, the function of the PC pathway in the peripheral retina does not depend on recognition between individual members of bipolarganglion cell mosaics. 2...New groundbreaking findings in taste, smell and chemical irritation
... fat sensors -- Eating a high fat diet leads to a peripheral insensitivity to fats both in terms of expression of fat receptors and how taste cells respond to fats. This insensitivity to fats leads to a greater intake of fat in the diet and contributes to and maintains the obese state. Making scents of olfa...Marijuana-like compounds suppress the immune response
... There are two types of cannabinoid receptor: the peripheral cannabinoid receptor (CB2) which is predominantly found in immune cells, and the central cannabinoid receptor (CB1) which occurs in the central nervous system. Recent studies have suggested that CB2 may be involved in a wide range of physiologic ph......are found in small numbers in the bone marrow, the peripheral blood, and in cord blood, which is harvested from the umbilical cord at birth. Cord blood is increasingly being used for transplantation, but the low number of HSCs present in a unit of cord blood means that transplanted cells can be slow to establis...Epstein-Barr virus might kick-start multiple sclerosis
... response to the virus. "What we discovered in the peripheral blood of the MS patients were T cells that appeared to be primed for action against EBV," said Nancy Edwards, an HHMI-NIH research scholar at the National Institutes of Health (NIH) and co-author of the paper, which was published in advance online. ...New technology enables faster, more efficient cell harvest: Cell therapy meeting study
...from a broad range of biological samples including peripheral blood, bone marrow and umbilical cord blood. The Company is currently working with several companies in applying its filter harvest system to the development of innovative cell-based therapies in a variety of therapeutic areas, including orthopedics...Physicians and engineers pool resources to prevent stroke
...cular therapy and basic science of the central and peripheral nervous system. "According to the American Association of Neurological Surgeons, cerebral aneurysms affect up to six percent of the U.S. adult population," Metcalfe said. "Most aneurysms don't rupture, but if they do, the results are fatal in abou......lin secretion in response to glucose and enhancing peripheral insulin action. The challenge is to ascertain if these results in rodents can be translated to patients." Others who participated in the research include Drs. Mark Asnicar, Pradip K. Saha and Lawrence Chan, all of BCM....